Cytotoxicity of N-dodecanoyl-L-homoserine lactone and 5-N-dodecyl resorcinol to human granulocytes and monocytes: a comparative study

Sviridova, Tatyana; Deryabin, D. G.; Cyganok, Olga; Chereshnev, V. А.

doi:10.5114/ceji.2013.37752

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…The comprehensive picture of functional diversity of quorum‐sensing molecules and inhibitors is further muddied by marine pathogens weaponizing HSLs as virulence factors. For example, Pseudomonas aeruginosa produces N ‐dodecanoyl‐HSL 15 , a metabolite that effectively kills human immune cells …”

Section: Small‐molecule Signaling In Marine Ecosystemsmentioning

confidence: 99%

Bridging the Gap: Plant‐Endophyte Interactions as a Roadmap to Understanding Small‐Molecule Communication in Marine Microbiomes

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Balunas

2020

ChemBioChem

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Section: Small‐molecule Signaling In Marine Ecosystemsmentioning

confidence: 99%

Bridging the Gap: Plant‐Endophyte Interactions as a Roadmap to Understanding Small‐Molecule Communication in Marine Microbiomes

Samples

Balunas

2020

ChemBioChem

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“…Sviridova et al found that N- dodecanoyl-L-homoserine lactone (C12-HSL) ( 1 ), produced by Pseudomonas aeruginosa , was fatally toxic to human granulocytes and monocytes. 11 P. aeruginosa is a tenacious bacterium that can thrive in water, soil, and animals, including humans. 12 Regarding human hosts, P. aeruginosa presents the most danger to those who are immunocompromised such as burn victims and cystic fibrosis (CF) patients.…”

Section: Pathogenic Relationshipsmentioning

confidence: 99%

“…Despite the chemical similarities in these compounds, 2 lead to rapid lysis without apoptosis, whereas 1 lead to rapid apoptosis of human granulocytes and monocytes that were isolated from leukocyte-rich plasma. 11 C12-HSL ( 1 ) and 2 are similar in molecular weight, but have different functional groups, therefore eliciting distinct host responses. Both molecules have saturated lipid chains that contain the same number of carbon atoms, but the head group of 1 is a lactone whereas 2 has a benzenediol.…”

Section: Pathogenic Relationshipsmentioning

confidence: 99%

Calling All Hosts: Bacterial Communication In Situ

Cleary

Condren

Zink

et al. 2017

Chem

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Bacteria are cosmopolitan organisms that in recent years have demonstrated many roles in maintaining host equilibrium. In this review, we discuss three roles bacteria can occupy in a host: pathogenic, symbiotic, and transient, with a specific focus on how bacterial small molecules contribute to homeostasis or dysbiosis. First, we will dissect how small molecules produced by pathogenic bacteria can be used as a source for communication during colonization and as protection against host immune responses. The ability to achieve a higher level of organization through small molecule communication gives pathogenic bacteria an opportunity for increased virulence and fitness. Conversely, in symbiotic relationships with hosts, small molecules are used in the initial acquisition, colonization, and maintenance of this beneficial population. Chemical signals can come from both the host and symbiont, and it is often observed that these interKingdom symbioses result in coevolution of both species involved. Furthermore, the transition from transient to commensal or opportunistic likely relies on molecular mechanisms. The small molecules utilized and produced by transient bacteria are desirable for both the immune and nutritional benefits they provide to the host. Finally, the advantages and disadvantages of modern analytical techniques that are available to researchers in order to study small molecules in situ is an important aspect of this review. It is our opinion that small molecules produced by bacteria are central to many biological processes and a larger focus on uncovering the function and identity of these small molecules is required to gain a deeper understanding of host-microbe associations.

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Enantiomeric impurities in chiral catalysts, auxiliaries, and synthons used in enantioselective syntheses. Part 5

et al. 2019

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The enantiomeric excess of chiral starting materials is one of the important factors determining the enantiopurity of products in asymmetric synthesis. Fifty‐one commercially available chiral reagents used as building blocks, catalysts, and auxiliaries in various enantioselective syntheses were assayed for their enantiomeric purity. The test results were classified within five impurities level (ie, <0.01%, 0.01%‐0.1%, 0.1%‐1%, 1%‐10%, >10%). Previously from 1998 to 2013, several reports have been published on the enantiomeric composition of more than 300 chiral reagents. This series of papers is necessitated by the fact that new reagents are forthcoming and that the enantiomeric purity of the same reagent can vary from batch to batch and/or from supplier to supplier. This report presents chiral liquid chromatography (LC) and gas chromatography (GC) methods to separate enantiomers of chiral compounds and evaluate their enantiomeric purities. The accurate and efficient LC analysis was done using newly introduced superficially porous particle (SPP 2.7 μm) based chiral stationary phases (TeicoShell, VancoShell, LarihcShell‐P, and NicoShell).

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Cytotoxicity of N-dodecanoyl-L-homoserine lactone and 5-N-dodecyl resorcinol to human granulocytes and monocytes: a comparative study

Abstract: Small molecules originating from microbes (SMOMs) play a significant role in bacterial-bacterial communication and in interactions between

Cited by 5 publications

References 20 publications

Bridging the Gap: Plant‐Endophyte Interactions as a Roadmap to Understanding Small‐Molecule Communication in Marine Microbiomes

Bridging the Gap: Plant‐Endophyte Interactions as a Roadmap to Understanding Small‐Molecule Communication in Marine Microbiomes

Calling All Hosts: Bacterial Communication In Situ

Enantiomeric impurities in chiral catalysts, auxiliaries, and synthons used in enantioselective syntheses. Part 5

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