Cytotoxicity and mechanical behavior of chitin–bentonite clay based polyurethane bio-nanocomposites

Zia, Khalid Mahmood; Zuber, Mohammad; Barikani, Mehdi; Hussain, Rizwan; Jamil, Tahir; Anjum, Sohail

doi:10.1016/j.ijbiomac.2011.09.010

Cited by 52 publications

(19 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the cytotoxicity of the synthesized PU bioNC was also affected by varying the Delite HPS bentonite nanoclay content in the chemical composition of the final synthesized materials. It was revealed that cytotoxicity level increased with increased bentonite nanoclay content ( Figure 16.8) [138]. The staining results also showed that increased concentration of bentonite nanoclay has adverse effects on the biocompatibility of the samples [138].…”

Section: Composites Containing Clay Nanoparticlesmentioning

confidence: 95%

“…The results revealed the well-dispersed, ordered, intercalated assembled layers of bentonite formed in the polyurethane (PU) matrix. In a similar study, the same authors fabricated PUBNC by using chitin, Delite  HPS bentonite nanoclay enriched in MMT, 4,4-diphenylmethane diisocyanate (MDI), and polycaprolactone polyol (CAPA 231) [138]. It was found that the mechanical properties of the synthesized materials were improved with increased Delite  HPS bentonite nanoclay content.…”

Section: Composites Containing Clay Nanoparticlesmentioning

confidence: 96%

“…It was revealed that cytotoxicity level increased with increased bentonite nanoclay content ( Figure 16.8) [138]. The staining results also showed that increased concentration of bentonite nanoclay has adverse effects on the biocompatibility of the samples [138]. Besides natural polymers (discussed above), synthetic polymers have been used as matrices to prepare polymer/clay nanocomposites.…”

Section: Composites Containing Clay Nanoparticlesmentioning

confidence: 99%

See 2 more Smart Citations

Bioactive Nanocomposites Containing Silicate Phases for Bone Replacement and Regeneration

Erol

Hum

Boccaccını

2012

Biomimetic Approaches for Biomaterials Development

View full text Add to dashboard Cite

Section: Composites Containing Clay Nanoparticlesmentioning

confidence: 95%

Section: Composites Containing Clay Nanoparticlesmentioning

confidence: 96%

Section: Composites Containing Clay Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Bioactive Nanocomposites Containing Silicate Phases for Bone Replacement and Regeneration

Erol

Hum

Boccaccını

2012

Biomimetic Approaches for Biomaterials Development

View full text Add to dashboard Cite

“…The addition of 1 wt% organo-MMT clays induced superior wear behavior and better tribological properties. Zia et al (2011) studied the impact of bentonite clays on mechanical properties and cytotoxicity of chitin-based polyurethane nanocomposites. The tensile strength of nanocomposites increased up to 300% with 4 wt% bentonite clay inclusions.…”

Section: The Effect Of Clay Nanofiller On Mechanical and Thermal Propmentioning

confidence: 99%

Development of biobased polymer/clay nanocomposites

Salam

Dong

Davies

2015

Fillers and Reinforcements for Advanced Nanocomposites

View full text Add to dashboard Cite

“…[21] On the other hand, there are some recent reports on other medical applications of bentonite, such as bentonite nanoclay use in surgical threads. [22]…”

Section: Introductionmentioning

confidence: 99%

CoolClot, a novel hemostatic agent for controlling life-threatening arterial bleeding

Mortazavi

Tavasoli²,

Atefi

et al. 2013

World Journal of Emergency Medicine

View full text Add to dashboard Cite

BACKGROUND:Uncontrolled bleeding is the first leading cause of preventable death in the battlefield and the 2nd cause of mortality in civil accidents. Incompressible hemorrhage control is among the interventions that drastically increase the survival rate in wound individuals. We have previously shown that a certain mixture of bentonite and zeolite minerals can significantly decrease the bleeding in rats.METHODS:In this study, nine healthy hybrid dogs were selected and after induction of anesthesia with ether, either arterial puncture by a needle or arteriotomy was performed on both groin regions of the dogs. For control arteries (either the right or left femoral artery), only pressure by sterilized gauze was performed, while for the femoral arteries of the opposite side, our invented hemostatic agent, namely CoolClot, was topically used before applying the pressure. In the second stage of the study, to assess the coagulation time, blood samples were collected from 10 volunteer students.RESULTS:CoolClot significantly decreased the bleeding time in animals whose femoral arteries were cut or punctured. In the human phase of the study, the mean coagulation time in control blood samples was 253.4±44.1 seconds, whereas it was 149.5±50.0, 162.3±74.6 and 143.4±114.6 seconds, respectively in blood samples treated with bentonite, zeolite and CoolClot (P<0.05).CONCLUSIONS:As controlling bleeding after a life-threatening arterial damage is critical for increasing the chance of survival, the results obtained in this study indicate the significant efficacy of CoolClot in shortening the bleeding time. Our experiments also indicate that CoolClot can significantly reduce the clotting time in human blood samples.

show abstract

Cytotoxicity and mechanical behavior of chitin–bentonite clay based polyurethane bio-nanocomposites

Cited by 52 publications

References 22 publications

Bioactive Nanocomposites Containing Silicate Phases for Bone Replacement and Regeneration

Bioactive Nanocomposites Containing Silicate Phases for Bone Replacement and Regeneration

Development of biobased polymer/clay nanocomposites

CoolClot, a novel hemostatic agent for controlling life-threatening arterial bleeding

Contact Info

Product

Resources

About