Cytotoxicity and cell imaging potentials of submicron color‐tunable yttria particles

Atabaev, Timur Sh.; Lee, Jong Ho; Han, Dong‐Wook; Hwang, Yoon Hwae; Kim, Hyung Kook

doi:10.1002/jbm.a.34168

Cited by 28 publications

(23 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All samples were measured under identical conditions so that the emission ratio could be compared. Figure 2 shows the PL emission spectrum revealed several main groups of emission lines, which were assigned to the 5 D 1 → 7 F 1 and 5 D 0 → 7 F j (where j = 0, 1, 2, 3) transitions within the Eu 3+ [12,13,14]. Partial replacement of Y 3+ with Gd 3+ in the host matrix allows easier charge transfer from Gd 3+ to Eu 3+ [15].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging

et al. 2017

Self Cite

View full text Add to dashboard Cite

Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y2O3 nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL). The cytotoxicity test showed that the prepared lanthanide-doped Y2O3 nanoprobes have good biocompatibility. The obvious contrast enhancement in the T1-weighted MR images suggested that these nanoprobes can be used as a positive contrast agent in MRI. In addition, the clear fluorescence images of the L-929 cells incubated with the nanoprobes highlight their potential for optical imaging. Overall, these results suggest that prepared lanthanide-doped Y2O3 nanoprobes can be used for simultaneous optical and MR imaging.

show abstract

Section: Resultsmentioning

confidence: 99%

“…For example, recent studies have suggested that a homogeneous yttria-lanthanides solid mixture can be obtained using the homogeneous urea precipitation method [11,12]. In addition, yttria-based nanostructures can potentially be used for optical biomaging purposes [13,14]. …”

Section: Introductionmentioning

confidence: 99%

Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, the similarities in the chemical properties and ionic radius of RE ions and Y 2 O 3 make it an attractive choice as a host material [6,8]. …”

Section: Introductionmentioning

confidence: 99%

“…Therefore, research into Y 2 O 3 codoped with other different RE activators is important because the color-tunable properties can be used in a wide range of applications. Although many studies have examined the optical properties of RE ion-doped Y 2 O 3 phosphors, only a few have investigated the codoping of two or more different ions in the same yttria host material [6,8,9]. …”

Section: Introductionmentioning

confidence: 99%

Color-tunable properties of Eu3+- and Dy3+-codoped Y2O3 phosphor particles

2012

Self Cite

View full text Add to dashboard Cite

Rare-earth phosphors are commonly used in display panels, security printing, and fluorescent lamps, and have potential applications in lasers and bioimaging. In the present study, Eu3+- and Dy3+-codoped uniform-shaped Y2O3 submicron particles were prepared using the urea homogeneous precipitation method. The structure and morphology of the resulting particles were characterized by X-ray diffraction, field emission scanning electron microscope, and field emission transmission electron microscope, whereas their optical properties were monitored by photoluminescence spectroscopy. The room-temperature luminescence color emission of the synthesized particles can be tuned from red to yellow by switching the excitation wavelength from 254 to 350 nm. The luminescence intensities of red and yellow emissions could be altered by varying the dopant concentration. Strong quenching was observed at high Eu3+ and Dy3+ concentrations in the Y2O3 host lattice.

show abstract

“…This observation may account partly for differential cellular responses to surface-functionalized MNPs of different sizes in normal fibroblasts vs. fibrosarcoma cells. Mechanisms for the cellular uptake of NPs are very complex and considered as endocytotic pathways such as phagocytosis, pinocytosis, nonspecific endocytosis, and receptor-mediated endocytosis [34,35]. Generally, the endocytosis of NPs depends on the interaction between NPs and the cell membrane.…”

Section: Resultsmentioning

confidence: 99%

Difference between Toxicities of Iron Oxide Magnetic Nanoparticles with Various Surface-Functional Groups against Human Normal Fibroblasts and Fibrosarcoma Cells

et al. 2013

Self Cite

View full text Add to dashboard Cite

Recently, many nanomedical studies have been focused on magnetic nanoparticles (MNPs) because MNPs possess attractive properties for potential uses in imaging, drug delivery, and theranostics. MNPs must have optimized size as well as functionalized surface for such applications. However, careful cytotoxicity and genotoxicity assessments to ensure the biocompatibility and biosafety of MNPs are essential. In this study, Fe3O4 MNPs of different sizes (approximately 10 and 100–150 nm) were prepared with different functional groups, hydroxyl (–OH) and amine (–NH2) groups, by coating their surfaces with tetraethyl orthosilicate (TEOS), 3-aminopropyltrimethoxysilane (APTMS) or TEOS/APTMS. Differential cellular responses to those surface-functionalized MNPs were investigated in normal fibroblasts vs. fibrosarcoma cells. Following the characterization of MNP properties according to size, surface charge and functional groups, cellular responses to MNPs in normal fibroblasts and fibrosarcoma cells were determined by quantifying metabolic activity, membrane integrity, and DNA stability. While all MNPs induced just about 5% or less cytotoxicity and genotoxicity in fibrosarcoma cells at lower than 500 μg/mL, APTMS-coated MNPs resulted in greater than 10% toxicity against normal cells. Particularly, the genotoxicity of MNPs was dependent on their dose, size and surface charge, showing that positively charged (APTMS- or TEOS/APTMS-coated) MNPs induced appreciable DNA aberrations irrespective of cell type. Resultantly, smaller and positively charged (APTMS-coated) MNPs led to more severe toxicity in normal cells than their cancer counterparts. Although it was difficult to fully differentiate cellular responses to various MNPs between normal fibroblasts and their cancer counterparts, normal cells were shown to be more vulnerable to internalized MNPs than cancer cells. Our results suggest that functional groups and sizes of MNPs are critical determinants of degrees of cytotoxicity and genotoxicity, and potential mechanisms of toxicity.

show abstract

Cytotoxicity and cell imaging potentials of submicron color‐tunable yttria particles

Cited by 28 publications

References 30 publications

Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging

Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging

Color-tunable properties of Eu3+- and Dy3+-codoped Y2O3 phosphor particles

Difference between Toxicities of Iron Oxide Magnetic Nanoparticles with Various Surface-Functional Groups against Human Normal Fibroblasts and Fibrosarcoma Cells

Contact Info

Product

Resources

About