Cytotoxicity and Antiangiogenic Activity ofTurbinaria ornataAgardh andPadina australisHauck Ethanolic Extracts

Abstract

Brown macroalgae species are constantly reported as potential sources of bioactive compounds useful in inhibiting cell proliferation and vascular formation. Thus, this study was conducted to determine and compare the in vitro cytotoxic activities of Turbinaria ornata Agardh and Padina australis Hauck ethanolic extracts against baker's yeast (Saccharomyces cerevisiae) using the resazurin reduction test (RRT) and investigate their in vivo antiangiogenic activity through duck (Anas platyrhynchos) chorioallantoic membrane (CAM) assay. Both T. ornata and P. australis ethanolic extracts exhibited cytotoxic activities at IC50 of 530.53 ppm and 528.78 ppm, respectively, and significant cytotoxicity was determined in 750 ppm and 1000 ppm concentrations of T. ornata and 1000 ppm concentration of P. australis. Also, both T. ornata and P. australis ethanolic extracts exhibited antiangiogenic activity (100% vascular inhibition) as all the concentrations of both species caused severe vascular damage in all the duck CAM samples treated. These results show the potential future application of these species for cytotoxic activities and vascular inhibition. The conduct of further tests using other model systems is recommended.

The Antiproliferative and Apoptosis-Inducing Effects of the Red Macroalgae Gelidium latifolium Extract against Melanoma Cells

“…Based on our results, GLE shows stronger cytotoxic activity compared to crude macroalgae extracts in other studies [53,80,81]. However, the cytotoxic activity of GLE was quite similar to Laurencia papillosa-125.8 ± 2.1 µg/mL and 121.…”

Bioinvasive Seaweed Genus, Turbinaria in Coral Reefs of Gulf of Mannar

“…Reportedly, T. ornata has potential therapeutic applications such as anticancer [27] anti-inflammatory [28] antiulcer [29] antibacterial [30] antidiabetic and antioxidant [31] antiangiogenic [32] and for cosmetics including oils, soaps, shower gels, shampoo, body oil, skin moisturizing creams and protective lotions in French Polynesia (www.pacifiquesud.com). The local people in Gulf of Mannar are already exploring the abundant resource of Sargassum species for industrial applications.…”

Optimization of ultrasound‐assisted extraction conditions for phenolics, antioxidant, and tyrosinase inhibitory activities of Vietnamese brown seaweed (Padina australis)

“…Padina australis, one of the brown seaweeds found in some Southeast Asian countries including Vietnam, Malaysia, Indonesia and Thailand, belongs to the class Heterokontophyta and a member of Phaeophyceae. Bioactive compounds that have been isolated from this species including polyphenols, flavonoids, alkaloids, saponins, steroids, terpenoids, tannins, fucoxanthin and fatty acids (Gunji et al, 2007;Haryani et al, 2010;Salosso et al, 2020;Shiney & Wilsy, 2014) that has been found to possess antiangiogenic, antibacterial, antituberculosis, antioxidant and antimicrobial activity (Canoy & Bitacura, 2018;Chiao-Wei et al, 2011;Latifah et al, 2019;Yu et al, 2019).…”