Cytotoxicity Analysis of Biosynthesized Selenium Nanoparticles Towards A549 Lung Cancer Cell Line

Selenium nanoparticles: Synthesis, in-vitro cytotoxicity, antioxidant activity and interaction studies with ct-DNA and HSA, HHb and Cyt c serum proteins

“…It is evident that the IC 50 values of our synthesized SeNPs were significantly lower than that of the reported SeNPs. Also, the mechanism behind their cytotoxicity can be explained with the diffusion of the SeNPs to the cell membrane via the ion channels and the contact with the nitrogen bases of DNA or intracellular proteins [ 38 ].

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Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects

“…The specific antimicrobial property of the plantmediated SeNPs might be due to their smaller size as the compared size of microorganisms which helps them to enter the cell membrane of microorganisms and causes cell death. 43,75 Another study reported that the plant-mediated SeNPs with smaller size and spherical shape had easy access into the bacterial cell, that's why it is well agreed upon that antimicrobial potential of the plant-based SeNPs is inversely proportional to its size which increases with decreases in the size of plant-mediated SeNPs. 87 Plant-based SeNPs are well known to be active against both Gram-positive (Staphylococcus aureus) and Gram-negative (Proteus sp, Escherichia coli and Klebsiella pneumonia) bacterial strains but it seems that SeNPs are more effective against Gram-negative bacteria because of their thin peptidoglycan cell wall.…”

“…However, the plant-based nanoparticles have potential antioxidant functional groups that have better stability, controlled release and biocompatibility with superior antioxidant profiles. 74 The plant-based SeNPs are well known due to their excellent antioxidant potential as evidenced in previous studies, 43,61,75,76 where plants-based SeNPs were explored to effectively scavenge the DPPH and ABTS free radicals in lesser time. The excellent antioxidant potential of the plant-based SeNPs is due to a higher level of nanoselenium that plays a significant role in an upturn of selenoenzymes like glutathione peroxidase that helps in 258 the protection of cells and tissues in vivo from free radicals.…”

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

“…To optimize SeNP bioproduction, the selenium precursor concentration (sodium selenite) varied from 10 to 30 mM and the impact of the pH and reaction time was assessed [102]. Besides, statistical optimization techniques might be used for the design of the experiment, such as the response surface methodology (RSM) [102,103]. Overall, the yield of NP synthesis has a direct correlation with the precursor concentration: the higher the concentration, the greater the production.…”