Cytotoxicity against cancer cells of chitosan oligosaccharides prepared from chitosan powder degraded by electrical discharge plasma

Chokradjaroen, Chayanaphat; Theeramunkong, Sewan; Yui, Hiroharu; Saito, Nagahiro; Rujiravanit, Ratana

doi:10.1016/j.carbpol.2018.08.037

Cited by 60 publications

(22 citation statements)

References 60 publications

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“…Here, a brief explanation of the electrical discharge under an aqueous solution (e.g., electrical breakdown, formation of reactive species, and influencing factors) in the SPP is provided. [14,29,30], (b) [31,32], (c) [27,[33][34][35], (d) [36][37][38], (e) [15,22], and (f) [39][40][41][42]. [31,32], (c) [27,[33][34][35], (d) [36][37][38], (e) [15,22], and (f) [39][40][41][42].…”

Section: Solution Plasma Process (Spp): Chemistry and Influencing Parametersmentioning

confidence: 99%

“…However, the process is time-consuming, and the cost of handling is relatively high. In recent years, exploring alternative techniques for chitin and chitosan modification, physical methods for the modification of chitin and chitosan, have focused on the utilization of various kinds of energy, [39,41,67,74], hypocholesterolemic effect [75], anti-microbial: gram-positive [76], anti-microbial: gram-negative [76], anti-inflammatory [77], anti-tumor/anti-cancer [39,49,74,78], anti-allergy [79], calcium absorption [80], anti-oxidant [81]).…”

Section: Chitin and Chitosanmentioning

confidence: 99%

“…In addition, carboxylic acids were reported to be safe for use in food and drug production [108]. Furthermore, the fine power of chitosan was used and provided a good dispersion in the SPP reactor and led to the simpler degradation process of chitosan, compared to other previous techniques, as shown in Figure 14 [39]. A variety of sodium salts (e.g., NaCl, NaI, NaNO 3 , and Na 2 SO 4 ) and metal chloride (e.g., CaCl 2 , MnCl 2 , and CeCl 3 ) used in this work exhibited the different influence on the rate of degradation on the main structure (i.e., pyranose rings and functional groups) of chitosan.…”

Section: Reduction Of Molecular Weight and Destruction Of Crystallinity Via Sppmentioning

confidence: 99%

“… Schematic illustration of the SPP with pin-to-pin electrode configuration and its application with different distances between electrodes: ( a ) [ 14 , 29 , 30 ], ( b ) [ 31 , 32 ], ( c ) [ 27 , 33 , 34 , 35 ], ( d ) [ 36 , 37 , 38 ], ( e ) [ 15 , 22 ], and ( f ) [ 39 , 40 , 41 , 42 ]. …”

Section: Figurementioning

confidence: 99%

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Insight on Solution Plasma in Aqueous Solution and Their Application in Modification of Chitin and Chitosan

Chokradjaroen

Niu

Panomsuwan

et al. 2021

IJMS

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Sustainability and environmental concerns have persuaded researchers to explore renewable materials, such as nature-derived polysaccharides, and add value by changing chemical structures with the aim to possess specific properties, like biological properties. Meanwhile, finding methods and strategies that can lower hazardous chemicals, simplify production steps, reduce time consumption, and acquire high-purified products is an important task that requires attention. To break through these issues, electrical discharging in aqueous solutions at atmospheric pressure and room temperature, referred to as the “solution plasma process”, has been introduced as a novel process for modification of nature-derived polysaccharides like chitin and chitosan. This review reveals insight into the electrical discharge in aqueous solutions and scientific progress on their application in a modification of chitin and chitosan, including degradation and deacetylation. The influencing parameters in the plasma process are intensively explained in order to provide a guideline for the modification of not only chitin and chitosan but also other nature-derived polysaccharides, aiming to address economic aspects and environmental concerns.

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Section: Solution Plasma Process (Spp): Chemistry and Influencing Parametersmentioning

confidence: 99%

Section: Chitin and Chitosanmentioning

confidence: 99%

Section: Reduction Of Molecular Weight and Destruction Of Crystallinity Via Sppmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Insight on Solution Plasma in Aqueous Solution and Their Application in Modification of Chitin and Chitosan

Chokradjaroen

Niu

Panomsuwan

et al. 2021

IJMS

Self Cite

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“…N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride with an average molecular weight of 250 kDa and degree of substitution between 50 % and 80 % have been shown to exert a strong interaction with the recombinant ectodomain of the S protein of HCoV, thus blocking S protein-host cellular interaction and virus infection ( Milewska et al, 2016 ). Chito-oligosaccharides (molecular weight = 1000–12000 Da, degree of deacetylation = 65–70 %), prepared via electrical discharge plasma treatment of chitosan in the liquid state, induce apoptotic death in MCF-7 breast cancer cells ( Chokradjaroen et al, 2018 ). The chito-oligosaccharides have also been found to be effective in killing of PC3 (prostate cancer cells), A549 (lung cancer cells) and HepG2 (hepatoma cells) with lower molecular weights being more effective than larger molecular weight counterparts.…”

Section: Future Perspectivesmentioning

confidence: 99%

A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers

Rasul

Muniandy

Zakaria

et al. 2020

Carbohydrate Polymers

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Preparation and antibacterial effect of chitooligosaccharides monomers with different polymerization degrees from crab shell chitosan by enzymatic hydrolysis

Zhao

Liu

Sui

et al. 2022

Biotech and App Biochem

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This study aimed to explore the structure and antibacterial properties of chitooligosaccharide monomers with different polymerization degrees and to provide a theoretical basis for inhibiting Salmonella infection. Chitosan was used as a raw material to prepare and separate low‐molecular‐weight chitooligosaccharides. Chitobiose, chitotriose, and chitotetraose were obtained by gradient elution with cation exchange resin. The molecular weights and acetyl groups of the three monomers were determined by matrix‐assisted laser desorption ionization time‐of‐flight (MALDI‐TOF) and nuclear magnetic resonance (NMR), respectively. Three chitooligosaccharide monomers were used to explore the antibacterial effect on Salmonella. The results showed that the degree of deacetylation of chitosan was 92.6%, and the enzyme activity of chitosanase was 102.53 U/g. Within 18 h, chitosan was enzymatically hydrolyzed to chitooligosaccharides containing chitobiose, chitotriose, and chitotetraose, which were analyzed by thin‐layer chromatography (TLC) and MALDI‐TOF. MALD‐TOF and TLC showed that the separation of monomers with ion exchange resins was effective, and NMR showed that there was no acetyl group. Chitobiose had a poor inhibitory effect on Salmonella, and chitotriose and chitotetraose had equivalent antibacterial effects.

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Cytotoxicity against cancer cells of chitosan oligosaccharides prepared from chitosan powder degraded by electrical discharge plasma

Cited by 60 publications

References 60 publications

Insight on Solution Plasma in Aqueous Solution and Their Application in Modification of Chitin and Chitosan

Insight on Solution Plasma in Aqueous Solution and Their Application in Modification of Chitin and Chitosan

A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers

Preparation and antibacterial effect of chitooligosaccharides monomers with different polymerization degrees from crab shell chitosan by enzymatic hydrolysis

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