Cytotoxicities of enniatins H, I, and MK1688 from Fusarium oxysporum KFCC 11363P

Lee, Hee-Seok; Song, Hwayoung; Jeong, Jin-Ho; Shin, Cha‐Gyun; Choi, Sang‐Un; Lee, Chan

doi:10.1016/j.toxicon.2008.02.002

Cited by 48 publications

(35 citation statements)

References 30 publications

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“…The biological activities of natural cyclic depsipeptides from other species including insects and plants and chemically synthesised cyclic peptides are diverse (Faulkner, 1988). They exhibit cytotoxic (Hyun, Lee, Lee, & Shin, 2008;Lee et al, 2008), antifungal (Fukuda et al, 2004), and antibiotic (Fairlie, Abbenante, & March, 1995) properties. Interestingly, the genus Fusarium, which is associated with higher marine plants, has proved to be a promising source for the production of the novel cytotoxic cyclic depsipeptides, sansalvamide and N-methylsansalvamide.…”

Section: Introductionmentioning

confidence: 99%

A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide produced by Fusarium solani KCCM90040, isolated from potato

Song

Lee

2011

Food Chemistry

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Section: Introductionmentioning

confidence: 99%

A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide produced by Fusarium solani KCCM90040, isolated from potato

Song

Lee

2011

Food Chemistry

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“…After selecting the optimal cereal substrate, F. solani KCCM90040 was incubated at 4 different temperatures (15,25,35, and 45°C), 5 different initial moisture contents (10,20,30,40, and 50%), and 4 different growth times (1, 2, 3, and 4 weeks) to test the effect of culture conditions on the production of neoN-methylsansalvamide. After determination of the range of culture conditions, RSM was applied to further optimize the culture conditions.…”

Section: Methodsmentioning

confidence: 99%

“…7,8) These cyclic depsipetides exhibit numerous pharmaceutical benefits such as cytotoxic, 9,10) antifungal, 11) and antibiotic 1) effects as well as calcium channel antagonism. 12) Another cytotoxic cyclic pentadepsipeptides, sansalvamide analogs, were produced by Fusarium strains.…”

mentioning

confidence: 99%

Optimization of culture conditions of Fusarium solani for the production of neoN-methylsansalvamide

Lee

Phat

Nam

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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The aim of this study was to optimize the culture conditions of Fusarium solani KCCM90040 on cereal grain for the production of neoN-methylsansalvamide, a novel low-molecular-weight cyclic pentadepsipeptide exhibiting cytotoxic and multidrug resistance reversal effects. From the analysis of variance results using response surface methodology, temperature, initial moisture content, and growth time were shown to be important parameters for the production of neoN-methylsansalvamide on cereal grain. A model was established in the present study to describe the relationship between environmental conditions and the production of neoN-methylsansalvamide on rice, the selected cereal grain. The optimal culture conditions were determined at 25.79°C with the initial moisture content of 40.79%, and 16.19 days of growth time. This report will give important information concerning the optimization of environmental conditions using statistic methodology for the production of a new cyclic pentadepsipeptide from fungi.Key words: cyclic pentadepsipeptides; Fusarium solani; environmental conditions; response surface methodology Various reviews of peptides from fungi have revealed that Fusarium strains found in fungi-infected plants produce several cyclic depsipeptides such as beauvericin, 1) enniatins, 2,3) zygosporamide, 4) and neosansalvamide analogs 5,6) via the non-ribosomal peptide synthesis system. 7,8) These cyclic depsipetides exhibit numerous pharmaceutical benefits such as cytotoxic, 9,10) antifungal, 11) and antibiotic 1) effects as well as calcium channel antagonism.12) Another cytotoxic cyclic pentadepsipeptides, sansalvamide analogs, were produced by Fusarium strains. 13,14) Sansalvamide A was first reported from the marine micro-organism Halodule wrightii, 14)This N-methylated sansalvamide exhibited in vitro cytotoxicity in a National Cancer Institute human tumor cell line screen (EC 50 = 8.3 μmol).14) Sansalvamide showed cytototoxic potency against HCT116 (colon carcinoma), COLO205 (colon), and SK-MEL-2 (melanoma) cancer cell lines with EC 50 values of 9.8, 3.5, and 5.9 μg/mL, respectively. 13) Sansalvamide and its analogs, which were produced by organic synthesis, caused marked time-and concentration-dependent inhibition of DNA synthesis and cell proliferation of human pancreatic cancer cell lines. [15][16][17] Furthermore, sansalvamide and its analogs showed a strong cytotoxic effect against multidrug resistance (MDR) human colon cancer cell lines.18) These anticancer effects of sansalvamide analogs can be attributed to their inhibition of topoisomerase I, and their cytotoxicity may be mediated by this mechanism.17,19) Sansalvamide analogs exhibited cytotoxic activity against human cancer cell lines, suggesting that they could be valuable therapeutic agents. 17,18) Our research group isolated several Fusarium strains producing different cyclic depsipeptides including enniatins H, I, and MK1688 with beauvericin. 20) Interestingly, one isolate (Fusarium solani KCCM90040) produced a novel cyclic pentadepsipeptide, n...

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“…Among peptone and NaNO 3 , peptone is the major source of nitrogen [33,34]. Being an intracellular product, only a small amount of BEA is exported into the medium [8,35]. Xu studied F. redolens Dzf2 mycelial culture along with macroporous polystyrene resin as sorbent increases the production of BEA from 194-265 mg/L.…”

Section: Biosynthesis Of Beauvericinmentioning

confidence: 99%

Pharmacological and Therapeutic Potential of Beauvericin: A Short Review

Sood¹,

S²,

Hu$^{³

et al. 2017

J Proteomics Bioinform

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An entomopathogenic fungus, Beauveria spp. has been known to have numerous pharmacological and therapeutic implications, especially, in terms of human health making it a suitable for ethnopharmacological use. Beauvericin is a cyclic hexadepsipeptide mycotoxin, a novel bio-metabolite derived from this fungus, exhibiting a very potent anticancer, cytotoxic activities, antiplatelet aggregation and antimicrobial activities. The current review discusses the therapeutic potential of beauvericin including pharmacological and biological activities which will certainly draw the attention of scientific community to improve the production of beauvericin for its use in medical fields.

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Cytotoxicities of enniatins H, I, and MK1688 from Fusarium oxysporum KFCC 11363P

Cited by 48 publications

References 30 publications

A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide produced by Fusarium solani KCCM90040, isolated from potato

A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide produced by Fusarium solani KCCM90040, isolated from potato

Optimization of culture conditions of Fusarium solani for the production of neoN-methylsansalvamide

Pharmacological and Therapeutic Potential of Beauvericin: A Short Review

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