A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide produced by Fusarium solani KCCM90040, isolated from potato

Song, Hwayoung; Lee, Hee-Seok; Lee, Chan

doi:10.1016/j.foodchem.2010.11.023

Cited by 17 publications

(20 citation statements)

References 29 publications

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“…Since this first report, nearly 30 Fusarium species have been reported to be able to produce ENNs. These species that belong to eight different Fusarium species complexes are gathered in Figure , together with the host plant from which they have been isolated. ,,,,,,− With regard to small grain cereals, strains from three common FHB complexes are associated with ENN production, the Fusarium tricinctum, Fusarium sambucinum, and Fusarium sporotrichioides complexes . In maize and rice, in addition to ENN-producing strains of the three former complexes, strains from the Fujikuroi complex (F.…”

Section: Fusarium Species Responsible For the Contamination Of Crops ...mentioning

confidence: 99%

Fusarium Mycotoxins Enniatins: An Updated Review of Their Occurrence, the Producing Fusarium Species, and the Abiotic Determinants of Their Accumulation in Crop Harvests

Gautier

Pinson‐Gadais

Richard‐Forget

2020

J. Agric. Food Chem.

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Cereal grains and their processed food products are frequently contaminated with mycotoxins produced by the Fusarium genus. Enniatins (ENNs), which belong to the so-called "emerging mycotoxins" family, are among the most frequently found in small grain cereals. Health hazards induced by a chronic exposure to ENNs or an association of ENNs with other major mycotoxins is a risk that cannot be excluded given the current toxicological data. Thus, efforts must be pursued to define efficient control strategies to mitigate their presence in cereal grains. A key condition for achieving this aim is to gain deep and comprehensive knowledge of the factors promoting the appearance of ENNs in crop harvests. After an update of ENN occurrence data, this review surveys the scientific literature on the Fusarium species responsible for ENN contamination and covers the recent advances concerning the abiotic determinants and the genetic regulation of ENN biosynthesis.

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Section: Fusarium Species Responsible For the Contamination Of Crops ...mentioning

confidence: 99%

Fusarium Mycotoxins Enniatins: An Updated Review of Their Occurrence, the Producing Fusarium Species, and the Abiotic Determinants of Their Accumulation in Crop Harvests

Gautier

Pinson‐Gadais

Richard‐Forget

2020

J. Agric. Food Chem.

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“…Another new analog of sansalvamide A ( 228 ), neo- N -methylsansalvamide ( 211 ), was isolated from the fungus Fusarium solani KCCM90040 derived from the potato in Korea. The new cyclic pentadepsipeptide was able to inhibit in vitro cell growth of A549, SK-OV-3, SK-MEL-2 (human melanoma) and MES-SA (human uterine sarcoma) cells with EC 50 values ranging from 10.0 to 14.74 µM [ 303 ]. Moreover, synergistic effects of neo- N -methylsansalvamide and paclitaxel were also observed when acting against MES-SA, HCT15 (colorectal adenocarcinoma) and two multidrug resistance sublines (MES-SA/DX5 (human uterine corpus sarcoma) and HCT15/CL05).…”

Section: Fungi-derived Anticancer Cyclopeptidesmentioning

confidence: 99%

Natural Cyclopeptides as Anticancer Agents in the Last 20 Years

Zhang

Xia

Zhang

2021

IJMS

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Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino acids. A large number of natural cyclopeptides have been reported to be highly effective against different cancer cells, some of which are renowned for their clinical uses. Compared to linear peptides, cyclopeptides have absolute advantages of structural rigidity, biochemical stability, binding affinity as well as membrane permeability, which contribute greatly to their anticancer potency. Therefore, the discovery and development of natural cyclopeptides as anticancer agents remains attractive to academic researchers and pharmaceutical companies. Herein, we provide an overview of anticancer cyclopeptides that were discovered in the past 20 years. The present review mainly focuses on the anticancer efficacies, mechanisms of action and chemical structures of cyclopeptides with natural origins. Additionally, studies of the structure–activity relationship, total synthetic strategies as well as bioactivities of natural cyclopeptides are also included in this article. In conclusion, due to their characteristic structural features, natural cyclopeptides have great potential to be developed as anticancer agents. Indeed, they can also serve as excellent scaffolds for the synthesis of novel derivatives for combating cancerous pathologies.

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“…Neo- N -methylsansalvamide expressed in vitro cytotoxic effects on different human cancer cell lines. The EC 50 values of neo - N -sansalvamide against the four human cancer cell lines A549, SK-OV-3, SK-MEL-2 and MES-SA were 10.7 ± 0.15, 11.2 ± 1.23, 10.02 ± 0.53, and 14.0 ± 0.74 µM, respectively [30].…”

Section: Cyclopentadepsipeptidesmentioning

confidence: 99%

Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research

Sivanathan

Scherkenbeck

2014

Molecules

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Abstract:Faced with the need to find new drugs for all kinds of diseases, science sees that Nature offers numerous classes of compounds showing an impressively high biological potential. Among those are the cyclodepsipeptides, hybrid structures composed of amino and hydroxy acids. In the past decades numerous cyclodepsipeptides have been isolated and their potential as drugs has been studied extensively. For several cyclodepsipeptides total syntheses both in solution and on solid-phase have been established, allowing the production of combinatorial libraries. In addition, the biosynthesis of specific cyclodepsipeptides has been elucidated and used for the chemoenzymatic preparation of nonnatural analogues. This review summarizes the recent literature on cyclic tetra-to decadepsipeptides, composed exclusively of α-amino-and α-hydroxy acids.

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A new cytotoxic cyclic pentadepsipeptide, neo-N-methylsansalvamide produced by Fusarium solani KCCM90040, isolated from potato

Cited by 17 publications

References 29 publications

Fusarium Mycotoxins Enniatins: An Updated Review of Their Occurrence, the Producing Fusarium Species, and the Abiotic Determinants of Their Accumulation in Crop Harvests

Fusarium Mycotoxins Enniatins: An Updated Review of Their Occurrence, the Producing Fusarium Species, and the Abiotic Determinants of Their Accumulation in Crop Harvests

Natural Cyclopeptides as Anticancer Agents in the Last 20 Years

Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research

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