Cytotoxic turrianes from Kermadecia elliptica: Hemisynthesis and biological activities of kermadecin A derivatives

Khazem, Mays; Gaslonde, Thomas; Dumontet, Vincent; Poullain, Cyril; Litaudon, Marc; Michel, Sylvie

doi:10.1016/j.phytol.2014.10.006

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Although we cannot rule out an artifactual origin, it is likely that spirokermelin is a genuine natural product. Indeed, two different chemical investigations were conducted in 2008 and 2016 from 3 and 16 kg of barks,, respectively, leading to the isolation of spirokermelin in comparable yields (≈ 0.000033 % and 0.000056 %, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…Kermadecins A and B showed significant cytotoxic activities against KB and L1210 cancer cell lines, whereas kermadecins D and J and isokermadecin D exhibited a good inhibitory effect on acetylcholinesterase , . Recently, a series of derivatives of kermadecin A has been synthesized from the natural product to conduct structure–activity relationship studies . These studies required the extraction of 16 kg of barks of K. elliptica leading to the isolation of 450 mg of kermadecin A after several purification steps.…”

Section: Introductionmentioning

confidence: 99%

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Spirokermeline: A Macrocyclic Spirolactone from Kermadecia elliptica Brongn. & Gris

et al. 2018

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Spirokermeline, a new macrocyclic compound derived from resorcinol, was isolated from Kermadecia elliptica, an endemic species of New Caledonia. The structure of spirokermeline was elucidated on the basis of spectroscopic analysis and X‐ray single‐crystal diffraction analysis. This is the first time that a 3H,3′H‐spiro[benzofuran‐2,1′‐isobenzofuran]‐3,3′‐dione was isolated from higher plants and only the second time that this scaffold was found in nature. A possible biosynthetic pathway is proposed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spirokermeline: A Macrocyclic Spirolactone from Kermadecia elliptica Brongn. & Gris

et al. 2018

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“…Different types of assays were used in the cytotoxic analysis of the Proteaceae species, including trypan blue dye [173], the MTT assay [98,151,155,[174][175][176][177][178][179], XTT assay [159], MTS assay [143,[180][181][182], WST-1 assay [38], brine shrimp lethality assay [138,183,184], resazurin reduction assay [185], and fluorescein diacetate assay [152]. Most of the studies chose HepG2, the isolation of hepatocellular carcinoma, to be considered as the cell line.…”

Section: Cytotoxicitymentioning

confidence: 99%

A Review of Phytochemicals and Bioactive Properties in the Proteaceae Family: A Promising Source of Functional Food

Zhang,

Netzel,

Pengelly

et al. 2023

Antioxidants

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In recent decades, natural plant-based foods have been increasingly used to improve human health due to unhealthy modern dietary patterns, such as the consumption of foods high in sugar and fat. Many indigenous species have been used by Aboriginal peoples for their food and therapeutic properties. Thus, it is important to understand the health-enhancing bioactive profile of Australian indigenous species. The Proteaceae family, such as the genera of Protea, Macadamia, and Grevillea, have been commercially used in the horticulture and food industries. Researchers have reported some findings about Persoonia species, one of the genera in the Proteaceae family. The aim of this review was to provide an overview of the family Proteaceae and the genus Persoonia, including distribution, traditional and commercial uses, phytochemicals, bioactive properties, potential opportunities, and challenges. In this review, bioactive compounds and their properties related to the health benefits of the Proteaceae family, particularly the Persoonia genus, were reviewed for potential applications in the food industry.

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Current knowledge on chemistry of Proteaceae family, and biological activities of their bis-5-alkylresorcinol derivatives

2022

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Cytotoxic turrianes from Kermadecia elliptica: Hemisynthesis and biological activities of kermadecin A derivatives

Cited by 5 publications

References 18 publications

Spirokermeline: A Macrocyclic Spirolactone from Kermadecia elliptica Brongn. & Gris

Spirokermeline: A Macrocyclic Spirolactone from Kermadecia elliptica Brongn. & Gris

A Review of Phytochemicals and Bioactive Properties in the Proteaceae Family: A Promising Source of Functional Food

Current knowledge on chemistry of Proteaceae family, and biological activities of their bis-5-alkylresorcinol derivatives

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