Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits

Ntalli, Nikoletta; Cottiglia, Filippo; Bueno, Carlos Alberto; Alché, Laura E.; Leonti, Marco; Vargiu, Simona; Bifulco, Ersilia; Menkissoglu‐Spiroudi, Urania; Caboni, Pierluigi

doi:10.3390/molecules15095866

Cited by 58 publications

(33 citation statements)

References 35 publications

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“…The eluents of hexane, dichloromethane (DCM), ethyl acetate (EA) and ethanol were used in a gradient to increase the polarity. By elution with DCM/AE (60/40), 34.0 mg was obtained, the components of which were identified by spectroscopic data (IR, 1 H and 13 C NMR, MS) and compared with the literature values (Lavie et al, 1966;Ntalli et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

Insecticidal and growth inhibiting action of the supercritical extracts of Melia azedarach on Spodoptera frugiperda

Scapinello

Oliveira

Chiaradia³

et al. 2014

Rev. bras. eng. agríc. ambient.

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A B S T R A C TThis study evaluates the effects of supercritical carbon dioxide extracts obtained from the fruit of Melia azedarach L. (Meliaceae) on the development of Spodoptera frugiperda J.E. Smith, 1797 (Lepidoptera: Noctuidae), from the larval period until the insect adulthood. For this purpose, a laboratory-scale extraction unit was operated at 60 °C and 200 bar. Larval mortality increased by raising the extract concentration tested: the value of LC 50 calculated by Probit analysis was 376.74 mg kg -1 , and at a concentration of 5000 mg kg -1 , the mortality was 100%. The extract exhibited insect growth inhibitory activity in the higher concentrations (500 mg kg -1 , 1000 mg kg -1 and 5000 mg kg -1 ), due to antifeedant action, resulting in larvae and pupae with mass and body length significantly smaller than the control. At the lowest concentration tested (100 mg kg -1 ), bioactive effects from the adult stage of the insect were observed, with low viability pupal and adults presenting morphological deformities, hence indicating chronic toxicity effect.Ação inseticida e inibitória de crescimento de extratos supercríticos de Melia azedarach sobre Spodoptera frugiperda R E S U M O Este estudo avaliou os efeitos do extrato de frutos de Melia azedarach L. (Meliaceae) obtido através do solvente dióxido de carbono supercrítico sobre o desenvolvimento de Spodoptera frugiperda J.E. Smith, 1797 (Lepidoptera: Noctuidae), desde o período larval até a fase adulta do inseto. Para obtenção do extrato, uma unidade de extração em escala laboratorial foi operada a 60 °C e 200 bar. O extrato, quando adicionado à dieta artificial das larvas, demonstrou ação inseticida, a CL50 calculada através da análise de Probit foi de 376,74 mg kg -1 , na concentração de 5000 mg kg -1 e a mortalidade foi de 100%. Nas concentrações mais elevadas (500, 1000 e 5000 mg kg -1 ) o extrato apresentou também atividade inibitória de crescimento nos insetos, devido à ação antialimentar, resultando em larvas e pupas com massa e comprimento corporal significativamente menores que o controle. Na menor concentração testada (100 mg kg -1 ) foram observados efeitos bioativos a partir da fase adulta do inseto, como baixa viabilidade de pupas e adultos com deformações morfológicas, indicando, portanto, efeito de toxicidade crônica.

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Section: Methodsmentioning

confidence: 99%

Insecticidal and growth inhibiting action of the supercritical extracts of Melia azedarach on Spodoptera frugiperda

Scapinello

Oliveira

Chiaradia³

et al. 2014

Rev. bras. eng. agríc. ambient.

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“…Limonoids of various Trichilia with a wide spectrum of biological effects such as potential antiviral, analgesic, insecticidal, and insect growth inhibition activity have been documented [5,6]. Previous investigations involving limonoids isolated of another Meliaceae species, namely Melia azedarach, have demonstrated antiproliferative activity against an adenocarcinoma epithelial cell line A549 [7]. Additionally, it has been proved that limonoids from Citrus fruits demonstrated in vitro the capacity to induce apoptosis and to inhibit the proliferation of neuroblastoma cells [8].…”

Section: Introductionmentioning

confidence: 99%

Lepidotrichilins A and B, New Protolimonoids with Cytotoxic Activity from Trichilia Lepidota (Meliaceae)

et al. 2013

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Two novel protolimonoids, named lepidotrichilins A (1) and B (2), four known protolimonoids, 21,23-epoxy-7α-21α-dihydroxyapotirucalla-14,24-dien-3-one (3), 21,23-epoxy-7α-21β-dihydroxyapotiru-calla-14,24-dien-3-one (4), dysorone D (5), deoxyflindissone (6), and the two steroids β-sitosterol (7) and stigmasterol (8) ) and the protolimonoid deoxy-flindissone (6; IC 50 9.3 µgmL −1 ) exhibited significant cytotoxic activity against the MOLT-4 and U937 leukemic cell lines.

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“…For this reason, ancients used the diluited infusion of leaves and bark to induce uterus relaxation or as sedative. Many studies focused on different compounds extracted from the plant, such as limonoids or triterpenoids, that exert cytotoxic activities [39,40]. Recently, new triterpenoids isolated from the fruit of Melia azedarach has been tested on human cancer cell lines including human leukemia cell line HL60, demonstrating their cytotoxicities thus opening new possibilities to use M. azedarach also for anticancer therapy [41].…”

Section: Melia Azedarachmentioning

confidence: 99%

Natural Compounds: Molecular Weapons against Leukemia’s

Taverna¹,

Corrado

2017

J Leuk

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Nowadays cancer is one of the main reasons of death all over the world and it is estimated that deaths caused by cancer will grow dramatically in the next decades. Even if chemotherapy is the election therapy for solid tumors, as well as leukemias and lymphomas, cancer treatments are in continuous evolution trying to solve the problem of resistance mainly due to low accumulation of the drug in tumor cells (MDR). Natural compounds represent a valid alternative to treat several disease and recently the scientific community focus on these natural compounds and plant metabolites with therapeutic activities and low toxicities compared with synthetic ones.A combination therapy, that join conventional chemotherapy with natural plant metabolites, is now considered a new promising strategy to overcome MDR and reduce cellular toxicity; in particular, in leukemia due to its very complex origin and development of leukemogenesis.Here, we want to summarize and update the recent applications of natural compounds in the treatment of leukemia.

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Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits

Cited by 58 publications

References 35 publications

Insecticidal and growth inhibiting action of the supercritical extracts of Melia azedarach on Spodoptera frugiperda

Insecticidal and growth inhibiting action of the supercritical extracts of Melia azedarach on Spodoptera frugiperda

Lepidotrichilins A and B, New Protolimonoids with Cytotoxic Activity from Trichilia Lepidota (Meliaceae)

Natural Compounds: Molecular Weapons against Leukemia’s

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