Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases

Neumann, Harald; Medana, Isabelle M.; Bauer, Jan; Lassmann, Hans

doi:10.1016/s0166-2236(02)02154-9

Cited by 426 publications

(314 citation statements)

References 71 publications

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“…Hence, CD4 + T cells may play a regulatory or modulatory role in this disease, rather than being the principal culprits; and detailed analyses of T lymphocytes in MS, including examination of brain tissue specimens, has determined that the majority of T cells are CD8 + (Booss et al, 1983;Traugott et al, 1983;Hauser et al, 1986a;Hauser et al, 1986b;McCallum et al, 1987). CD8 + T cells are found in MS lesions in the form of clonal populations, consistent with their having been locally expanded in response to a specific antigen (Babbe et al, 2000;reviewed, Steinman, 2001;Neumann et al, 2002). Antigen-specific CD8 + T cells are found in patients early in the course of MS (Jilek et al, 2007), and CD8 + T cells isolated from peripheral blood of MS patients contain clonally expanded populations that are specific for myelin antigens (Tsuchida et al, 1994;Dressel et al, 1997).…”

Section: Introductionmentioning

confidence: 93%

Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency

Frausto

Crocker

Eam

et al. 2007

Journal of Neuroimmunology

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The inoculation of MOG peptides into C57BL/6 mice induces CD4 + and CD8 + T cells, and recent work has shown that adoptive transfer of the latter population, after extensive in vitro stimulation, can cause EAE in naïve recipient mice. Herein, we have evaluated the incidence and severity of EAE, and the induction of CD4 + and CD8 + T cells, following MOG peptide inoculation of wt mice and of LMP-2KO mice that lack an intact immunoproteasome, a cytoplasmic organelle that is induced by chronic inflammation and that may be important for the presentation of MHC class I epitopes to CD8 + T cells. We report that EAE, evaluated by both clinical and histological criteria, is similar in LMP-2KO mice and wildtype C57B/6 mice (wt) in response to immunization with MOG peptides MOG 35-55 and MOG [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] , suggesting that the immunoproteasome does not play a key role in the development of demyelinating disease. Furthermore, and consistent with previous reports, peptidespecific CD8 + T cells were barely detectable in the CNS of peptide-immunized mice, although peptide-specific CD4 + T cells were abundant. Therefore, we used a new technique to look for autoreactive CD8 + T cells in MOG peptide-immunized mice, and we report the identification of CD4 + and CD8 + T cells that, as late as 19 days after peptide injection, are actively producing IFNγ in vivo, in response to in vivo antigen contact.

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Section: Introductionmentioning

confidence: 93%

Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency

Frausto

Crocker

Eam

et al. 2007

Journal of Neuroimmunology

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“…Within parenchymal lesions cytotoxic T cells can be detected with their cytolytic granules polarized towards demyelinated axons indicative of imminent T cell mediated killing [34]. Furthermore, there is a positive correlation between the abundance of CD8 T cells and the intensity of axonal damage [35,36].…”

Section: Cd8 T Cells and Their Subsets In Msmentioning

confidence: 99%

Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

et al. 2011

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a b s t r a c tMultiple sclerosis (MS) is an immune-mediated disease of the central nervous system leading to demyelination and axonal/neuronal loss. Cumulating evidence points to a key role for CD8 T cells in this disabling disease. Oligoclonal CD8 T cells reside in demyelinating plaques where they are likely to contribute to tissue destruction. Histopathological analyses and compelling observations from animal models indicate that cytotoxic CD8 T cells target neural cell populations with the potential of causing lesions reminiscent of MS. However, CD8 T cell differentiation results in several subsets of effector CD8 T cells that could be differentially implicated in the mechanisms contributing to tissue damage. Moreover CD8 regulatory T cells arise as important populations involved in restoring immune homoeostasis and in maintaining immune privileged sites. Here we examine the current literature pertaining to the role of CD8 effector and regulatory T cell subsets in the pathogenesis of MS.

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“…Une prépondérance très nette des LT CD8 par rapport aux LT CD4 est aussi observée au sein des manchons périvasculaires et des lésions parenchymateuses de SEP [8]. Les LT CD8 sont capables de polariser leurs granules cytotoxiques vers des oligodendrocytes et des axones en cours de démyélinisation [9]. des cellules tumorales et des neurones de molécules du CMH-I, chez les patients présentant un syndrome anti-Hu, suggère que ces cellules pourraient être la cible des LT CD8.…”

Section: Rôle Des Lt Cd8 Dans Les Maladies Inflammatoires Du Système unclassified

Migration et pathogénicité des lymphocytes T CD8 dans les maladies du système nerveux central

2015

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Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases

Cited by 426 publications

References 71 publications

Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency

Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency

Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

Migration et pathogénicité des lymphocytes T CD8 dans les maladies du système nerveux central

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