2011
DOI: 10.1016/j.febslet.2011.08.047
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Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

Abstract: a b s t r a c tMultiple sclerosis (MS) is an immune-mediated disease of the central nervous system leading to demyelination and axonal/neuronal loss. Cumulating evidence points to a key role for CD8 T cells in this disabling disease. Oligoclonal CD8 T cells reside in demyelinating plaques where they are likely to contribute to tissue destruction. Histopathological analyses and compelling observations from animal models indicate that cytotoxic CD8 T cells target neural cell populations with the potential of cau… Show more

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Cited by 63 publications
(39 citation statements)
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“…Although many studies have focused on the role of CD4 + cell populations in EAE and MS, CD8 + cells are also important (Saxena et al, 2011). Antigen-specific CD8 + cells infiltrate the CNS, causing inflammatory lesions in the optic nerve, brain and spinal cord, with focal loss of oligodendrocytes and axonal damage (Saxena et al, 2011). In our experiments we found a twofold reduction in CNS CD8 + cells from infected EAE mice compared to the Broth/EAE group.…”
Section: Discussionsupporting
confidence: 60%
See 1 more Smart Citation
“…Although many studies have focused on the role of CD4 + cell populations in EAE and MS, CD8 + cells are also important (Saxena et al, 2011). Antigen-specific CD8 + cells infiltrate the CNS, causing inflammatory lesions in the optic nerve, brain and spinal cord, with focal loss of oligodendrocytes and axonal damage (Saxena et al, 2011). In our experiments we found a twofold reduction in CNS CD8 + cells from infected EAE mice compared to the Broth/EAE group.…”
Section: Discussionsupporting
confidence: 60%
“…We anticipate that these dramatic changes in the immune cell populations are responsible for the difference in EAE clinical scores. Although many studies have focused on the role of CD4 + cell populations in EAE and MS, CD8 + cells are also important (Saxena et al, 2011). Antigen-specific CD8 + cells infiltrate the CNS, causing inflammatory lesions in the optic nerve, brain and spinal cord, with focal loss of oligodendrocytes and axonal damage (Saxena et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…However, because the administration of IFN-g worsened MS in a previous clinical trial (13), the role of Th1 cells in MS needs to be analyzed further. In addition, increasing evidence suggest a pathogenic role for cytotoxic effector T cells in MS (14,15). Moreover, a recent clinical trial of anti-IL12p40 Ab to block IL-12/IL-23 signaling failed to modulate MS (16), making it difficult to portray a complete picture of MS (9).…”
Section: Ultiple Sclerosis (Ms) Is An Inflammatory Demyelinating DImentioning
confidence: 99%
“…Interestingly, ... a significant up-regulation of natural killer receptor protein la/CD 161 as well as increased numbers of CD 161high CD8 T cells is seen in the peripheral blood of MS patients (25), and CD8+ T cells , and in particular CD8+ CD 161+ cells can express IL-22 and play an important role in the pathogenesis of autoimmunity (26). As all circulating Tc 17 cells are contained within the CD 161high subset, it is tempting to speculate that Tc do play a pathogenic role in MS (27) possibly togeth er with other cells, including neutrophils (28). IL-6-expressing monocyte/ma crophages (MM) were significantly augmented as well in all patients.…”
Section: Hementioning
confidence: 99%