Cytotoxic Sterols from Philippine Mushrooms

Ragasa, Consolacion Y.; Oyong, Glenn G.; Tan, Maria Carmen S.; Reyes, Mariquit M. De Los; Castro, Maria Ellenita G. de

doi:10.14233/ajchem.2020.22591

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…On the other hand, the presence of ergosterol has been found in P. florida, P. djamor, and P. eryngii (Ragasa, 2018). Ergosterol is a precursor of vitamin D2 produced via exposure to UV light, and exhibits antioxidant activity and prevents cardiovascular diseases (Selvamani et al, 2018;González et al, 2021;Koutrotsios et al, 2022).…”

Section: Lipidsmentioning

confidence: 99%

“…It has been observed that crude extracts and chemical fractions from Pleurotus fruiting bodies or mycelium contain compounds that exhibit anticancer effect toward several types of tumour cells, but this activity depends on the species. Extracts from P. pulmonarius, P. florida, and P. djamor have demonstrated efficacy against several cancer types or cell lines, including human hepatoma HepG2 cells, bladder carcinoma, and ovarian cancer, respectively (Selvi et al, 2011;Xu et al, 2012;Ragasa, 2018).…”

Section: Anticancer Activitymentioning

confidence: 99%

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Overview of Pleurotus spp., edible fungi with various functional properties

Juárez-Hernández,

Pérez-Zavala,

Román-Reyes

et al. 2023

IFRJ

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Pleurotus fungi, also known as basidiomycetous fungi, have been a part of human culture for thousands of years. They exhibit anticancer, antitumor, antibacterial, and immunomodulatory effects, having biotechnological, medicinal, and aesthetic applications. They are also versatile, highly resistant to illnesses and pests, and do not require special growing conditions. These properties make them readily marketable, and can be found in supermarkets worldwide, generating multimillion-dollar sale revenues. The global edible mushroom market was valued at USD 5.08 billion in 2021, which is expected to grow to USD 6.43 billion in 2028. China produces about 87% of Pleurotus spp. globally; other Asian countries generate 12%, and Europe and America account for approximately 1%. Pleurotus spp. have distinct functional characteristics, including high protein content with a proper essential amino acid score pattern, dietary fibre profile, high amounts of vitamins (e.g., B and D) and minerals (e.g., Fe, Zn, Cu, and Se), and low fat. Therefore, Pleurotus spp. can provide alternative industrial tools. The present review discusses Pleurotus spp. as biotechnological tools for acquiring metabolites of interest, studying them, and analysing bioactive substances that can be used in various fields, including medicine and food.

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Section: Lipidsmentioning

confidence: 99%

Section: Anticancer Activitymentioning

confidence: 99%

Overview of Pleurotus spp., edible fungi with various functional properties

Juárez-Hernández,

Pérez-Zavala,

Román-Reyes

et al. 2023

IFRJ

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“…Mushrooms, including L. tigrinus, C. comatus, P. cyanescens, P. antillarium, L. sajor-caju, L. strigosus, P. grammocephalus, T. elegans, Trichaleurina celebica, P. cystidiosus, P. sanguineus, and Xylaria papulis, have been shown to contain carbohydrates, proteins, crude fibers, crude fat, vitamins, and minerals and important bioactive metabolites such as alkaloids, flavonoids, phenols, coumarins, triterpenes, tannins, saponins, anthraquinones, athrones, and steroids [48,65,118,126,135,140,141,[146][147][148][149][150][151][152][153]. Other mushrooms, namely, C. reinakeana, C. comatus, V. volvacea, G. lucidum, P. cystidiosus, L. tigrinus, L. sajor-caju, Geastrum triplex, T. clypeatus, and S. commune have also been reported as source of amino acids, fatty acids, acyglycerols, triacylglycerols, ergosterol, and minerals [111,127,[154][155][156][157][158][159][160][161].…”

Section: Nutritional and Medicinal Properties Of Philippine Mushroomsmentioning

confidence: 99%

“…The therapeutic values and medicinal properties of edible mushrooms have found to stem from numerous biologically active compounds or metabolites [162][163][164]. Besides nutrients and active metabolites, Philippine mushrooms have been revealed to exhibit important bioactivities, including antioxidants [48,126,128,[133][134][135]147,[150][151][152][153]165,167] antibacterial [59,118,135,146,150,152,[167][168][169]] hypoglycemic [146,170] antihypertensive [154,155,171] anticancer [160,[172][173][174] anticoagulative, anti-inflammatory [154][155][156]175] teratogenic [65,148,[176][177][178][179][180][181]…”

Section: Nutritional and Medicinal Properties Of Philippine Mushroomsmentioning

confidence: 99%

Records of wild mushrooms in the Philippines: A review

Dulay¹,

Batangan²,

Kalaw³

et al. 2022

J App Biol Biotech

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Mushrooms are vital source of nutritious and functional food and income for humankind. They are widely reported as reservoir of highly varied biologically active compounds, which have been shown a variety of pharmacological properties particularly antioxidants, antimicrobial, anticancer, anti-inflammatory, anti-diabetic, and among others. Hence, increasing attention has been paid to the diversity, ethnomycology, cultivation, and application of wild useful mushrooms worldwide. In this context, this review aimed to establish the checklist of naturally occurring mushrooms in the Philippines based on the available reports from 2001 to 2021. A total of 2371 identified mushrooms from 64 available reports were taxonomically classified into 447 species, 193 genera and 72 families. The largest family was represented by Polyporaceae (72 species), followed by Agaricaceae (33), Hymenochaetaceae (18), Ganodermataceae (16), Psathyrellaceae (16), Marasmiaceae (15), Rusullaceae (15), Mycenaceae (14), Meruliaceae (13), and Tricholomataceae (12). However, the most reported species of Philippine wild mushrooms were Schizophyllum commune, Ganoderma lucidum, Ganoderma applanatum, Auricularia polytricha, and Microporus xanthopus. To the best of our knowledge, this is the most comprehensive checklist of wild mushroom species in the Philippines available to date, and approximately 75% of the species are considered newly reported species for the country. This review also highlights the ethnomycologically important, successfully cultivated, and pharmacologically significant wild mushroom species, describes the current status and challenges of Philippine mushroom research, and provides future opportunities. We hope that this review can provide comprehensive reference that will ignite high interest among Filipino researchers to achieve the maximum value and profitability of Philippine wild useful mushrooms.

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“…Studies on the cytotoxic and/or anticancer activities of Philippine endemic and indigenous mushrooms are limited. Ergosterol peroxide and ergosterol from dichloromethane extracts of Geastrum triplex and Termitomyces clypeatus , respectively, exhibited cytotoxic activities against breast cancer (MCF-7), colon cancer (HT-29), and small lung cell carcinoma (H69PR) [ 12 ]. A water-insoluble polysaccharide extract from Lenzites betulina showed strong cytotoxic effects against K562 leukemia cells [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway

Dulay

Valdez

et al. 2021

PLoS ONE

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Treatment of hematologic malignancies is a formidable challenge for hematologists and there is an urgent need to identify safe and efficacious agents either via synthesis in the laboratory or isolation from natural products. Here, we report the cytotoxicity of extracts from mushroom Gymnopilus purpureosquamulosus Høil (G. pps) and describe its molecular mechanisms. Using leukemia, lymphoma and multiple myeloma cell lines, 28–35 ppm G. pps extract inhibited cell proliferation by ~46–79%, which correlates with activation of apoptosis as indicated by increase in annexin V-positive cells (~5–8-fold), production of reactive oxygen species (~2–3-fold), cells in sub G0/G1 phase (~3–13-fold), caspase 3 enzymatic activity (~1.6–2.9-fold), DNA fragmentation, PARP1 cleavage and down-regulation of prosurvival proteins. Mitochondrial membrane potential decreased and leakage of pro-apoptotic factors to cytoplasm was observed, consistent with the activation of intrinsic apoptosis. Western blot analysis showed activation of the ASK1-MEK-SAPK/JNK and ASK1-P38 MAPK pathways possibly due to changes in the cellular redox status as suggested by decreased protein levels of peroxiredoxin, thioredoxin and thioredoxin reductase. Moreover, antioxidant N-acetylcysteine alleviated the cytotoxicity of G. pps. Pharmacological inhibition of SAPK/JNK and P38 alleviated the G. pps-mediated cytotoxicity. The extract activated apoptosis in leukemia and lymphoma patient cell samples but not in mononuclear cells from healthy donors further supporting the therapeutic values of G. pps for hematologic malignancies.

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Cytotoxic Sterols from Philippine Mushrooms

Cited by 5 publications

References 15 publications

Overview of Pleurotus spp., edible fungi with various functional properties

Overview of Pleurotus spp., edible fungi with various functional properties

Records of wild mushrooms in the Philippines: A review

Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway

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