Cytotoxic evaluation of silicon nitride-based ceramics

Silva, C.C. Guedes e; Higa, Olga Zazuco; Bressiani, José Carlos

doi:10.1016/j.msec.2004.08.007

Cited by 54 publications

(43 citation statements)

References 8 publications

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“…As starting materials, powders of Si 3 The samples were fired at 1750 °C for 60 minutes in a carbon resistance furnace using a nitrogen atmosphere and then analysed by X ray powder diffraction (Siemens D5000) to verify the crystalline phases. In order to observe the shape and grain size and their distribution by scanning electron microscopy (Jeol, JXA 6400), the surface samples were polished and plasma etched using CF 4 and O 2 .…”

Section: Sample Preparation and Characterizationmentioning

confidence: 99%

“…Many ceramic materials have been researched to overcome the limitations of alumina and zirconia. Silicon nitride is a promising candidate due to its non-cytotoxicity 5 , high wear resistance, high thermal shock resistance and relatively high mechanical strength and fracture toughness 3,4 . Once the bioinert ceramics do not form chemical bonds with the living tissues, their disadvantage is the bad fixation in the old bone 1 .…”

Section: Introductionmentioning

confidence: 99%

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Hydroxyapatite coating on silicon nitride surfaces using the biomimetic method

Silva¹,

Rigo

Marchi

et al. 2008

Mat. Res.

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Silicon nitride based ceramics are promising candidates for biomedical applications due to their chemical and dimensional stability associated to suitable mechanical strength and relatively high fracture toughness. However, the bioinert characteristics of these ceramics limit their application to situations where the formation of chemical bonds between the material and the tissue are not essential. A way to broaden the application field of these ceramics in medicine is promoting their bioactivity by means of a hydroxyapatite coating. Therefore, in this paper, samples of silicon nitride were coated with apatite using the biomimetic method. The treated silicon nitride surface was characterized by diffuse reflectance infrared Fourier transformed, X ray diffraction and scanning electron microscopy. The results showed that a layer of hydroxyapatite could be deposited by this method on silicon nitride samples surface.

show abstract

Section: Sample Preparation and Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite coating on silicon nitride surfaces using the biomimetic method

Silva¹,

Rigo

Marchi

et al. 2008

Mat. Res.

View full text Add to dashboard Cite

show abstract

“…These data have been validated by other authors; using two less favorable compositions of silicon nitride doped with yttrium and aluminum, Guedes et al reported a fracture toughness of 5 MPa m ½ and Vickers hardness values of 13 GPa. 25 The intrinsic material properties of silicon nitride make it suitable for articulation against bearing steel, which is a softer material than ceramic. Thus, silicon nitride has been used in rolling contact applications in automotive, turbomachinery, and power industries, where it has a significant advantage due to its low density (half that of bearing steel), low friction, corrosion resistance, and reliable performance under extreme conditions.…”

Section: Materials Properties Of Silicon Nitridementioning

confidence: 99%

“…44 In a separate investigation, the authors also found that silicon nitride-based ceramics did not elicit any toxic response when tested with standard cell culture models. 25 Howlett et al investigated the effect of silicon nitride on rabbit marrow stromal cells and their differentiation when grown in vitro and in vivo. 4 In vitro, marrow stromal cells attached to the ceramic discs; fresh marrow stromal cells formed cartilage, bone, and fibrous tissue when implanted with silicon nitride, or without, into the intraperitoneal cavity of rabbits.…”

Section: Biocompatibility Of Silicon Nitridementioning

confidence: 99%

The Rationale for Silicon Nitride Bearings in Orthopaedic Applications

Bal¹,

Rahaman²

2011

Advances in Ceramics - Electric and Magnetic Ceramics, Bioceramics, Ceramics and Environment

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“…It has been suggested that porous ceramics with tailored microstructures are potential structural component materials 11 . Silicon nitride is considered to be a promising biomaterial as it is non-cytotoxic 12 . Moreover, total hip arthroplastic bearings have been successfully manufactured from silicon nitride powder 13 .…”

Section: Introductionmentioning

confidence: 99%

Influence of additive system (Al2O3-RE2O3 , RE = Y, La, Nd, Dy, Yb) on microstructure and mechanical properties of silicon nitride-based ceramics

Marchi

Silva²,

Silva

et al. 2009

Mat. Res.

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Silicon nitride based ceramics have been widely used as structural ceramics, due mainly to their thermomechanical properties such as high density, high thermal shock resistance, corrosion resistance and chemical stability. The aim of this study was to determine the influence of rare earth and aluminum oxide additions as sintering aids on densification, microstructure and mechanical properties of silicon nitride. Silicon nitride mixtures with 91 wt. (%) Si 3 N 4 and 9% wt. (%) additives were prepared and sintered. The density, microstructure and mechanical properties of the sintered specimens of these mixtures were determined. In most specimens, scanning electron microscopic examination and X ray diffraction analysis revealed elongated grains of β-Si 3 N 4 with aspect ratio of about 2.0 and dispersed in a glassy phase. The density of the sintered specimens was higher than 94% of the theoretical density (td) and specimens with La 2 O 3 and Al 2 O 3 additions exhibited the highest value. The results of this investigation indicate that the rare earth ion size influences densification of silicon nitride, but this correlation was not observed in specimens containing two different rare earth oxides. The hardness values varied in direct proportion to the density of the specimens and the fracture toughness values were influenced by the composition of the intergranular glassy phase.

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Cytotoxic evaluation of silicon nitride-based ceramics

Cited by 54 publications

References 8 publications

Hydroxyapatite coating on silicon nitride surfaces using the biomimetic method

Hydroxyapatite coating on silicon nitride surfaces using the biomimetic method

The Rationale for Silicon Nitride Bearings in Orthopaedic Applications

Influence of additive system (Al2O3-RE2O3 , RE = Y, La, Nd, Dy, Yb) on microstructure and mechanical properties of silicon nitride-based ceramics

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