Cytotoxic effects of submicron- and nano-scale titanium debris released from dental implants: an integrative review

Messous, Redouane; Henriques, Bruno; Bousbaa, Hassan; Silva, Filipe; Teughels, Wim; Souza, Júlio C. M.

doi:10.1007/s00784-021-03785-z

Cited by 47 publications

(55 citation statements)

References 83 publications

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“…Studies based on publication date were not restricted during the search process. The present search of studies was carried out in accordance with previous integrative or systematic review articles 20‐22 …”

Section: Methodsmentioning

confidence: 99%

An integrative review on the toxicity of Bisphenol A (BPA) released from resin composites used in dentistry

et al. 2021

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The main aim of this study was to perform an integrative review on the release of bisphenol A (BPA) from resin‐matrix composites and potential toxic effects. A bibliographic search was performed on the PubMed platform using the following keywords: “Bisphenol A" OR “BPA” AND “resin composite” OR “composite resin” AND “toxicity” OR “cytotoxicity” OR “release”. Inclusion criteria involved in vitro and in vivo studies on the release and toxicity of BPA. Results highlighted the release of BPA from resin‐matrix composites due to insufficient polymerization and/or degradation of the polymeric matrix. BPA is part of the organic matrix of resin‐matrix composites and may be hydrolysed in human saliva, although studies report that low doses might not be detected by traditional chemical analysis. Studies exposing zebrafish embryos to different concentrations of Bis‐GMA, showed 55% mortality at 10 μM Bis‐GMA while 30% mortality was recorded at 1 μM Bis‐GMA. In patients, a BPA concentration of around 2.09 × 10−2 μg/ml was found in the saliva after placement of lingual orthodontic retainers with resin‐matrix composites. Also, the BPA molecule can be swallowed and absorbed by the oral/gastrointestinal mucosa, which might result in systemic toxicity. The degradation of resin‐matrix composites and release of BPA in oral environment are dependent on the organic matrix content and on the polymerization method. A increased release of BPA can lead to the absorption into oral and gastrointestinal mucosa with high risks of local and systemic toxicity.

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Section: Methodsmentioning

confidence: 99%

An integrative review on the toxicity of Bisphenol A (BPA) released from resin composites used in dentistry

et al. 2021

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“…Indeed, the chronic inflammatory response seems to be also modulated by titanium, especially when there is accumulation of bacterial biofilm. Higher amounts of titanium ions in peri-implant soft tissue with inflammatory process are observed when compared to healthy tissues [25,38]. Accordingly, titanium nanoparticles induced stronger proinflammatory response in macrophages regardless of the association with lipopolysaccharide from Porphyromonas gingivalis [40] and by increasing the secretion of interleukin (IL)-6, IL-1β, and tumor necrosis factor-alpha (TNF-α) by macrophages in vitro [38,40].…”

Section: Carcinogenic Mechanisms Associated With Osseointegrated Dental Implantsmentioning

confidence: 99%

“…Higher amounts of titanium ions in peri-implant soft tissue with inflammatory process are observed when compared to healthy tissues [25,38]. Accordingly, titanium nanoparticles induced stronger proinflammatory response in macrophages regardless of the association with lipopolysaccharide from Porphyromonas gingivalis [40] and by increasing the secretion of interleukin (IL)-6, IL-1β, and tumor necrosis factor-alpha (TNF-α) by macrophages in vitro [38,40]. Taken together, all these disturbances in the peri-implant microenvinoment may persist for years and, gradually, predispose the epithelial cells to sequential mutations until the malignant state is reached.…”

Section: Carcinogenic Mechanisms Associated With Osseointegrated Dental Implantsmentioning

confidence: 99%

Oral Cancer around Dental Implants: Are the Clinical Manifestations and the Oncogenic Mechanisms Unique?

Lopes-Santos¹,

Alberto²,

Filho³

et al. 2022

Dentistry

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Osseointegrated implants have been an optimal treatment option for dental rehabilitation of fully or partially edentulous patients. Although peri-implantitis remains as the most common local risk factor for dental implant failure, the development of oral cancer involving the soft tissue around the titanium may lead to early implants loss and impact the quality of life of the patient negatively. Oral squamous cell carcinoma (OSCC) is the most common malignancy among head and neck tumors. It has higher prevalence in men over 50 years old, and in tobacco and/or alcohol users. Unfortunately, oral cancer is often detected in advanced stages, when the treatment options are limited. Thus, OSCC typically has poor prognosis. Despite the recent advances in oral carcinogenesis understanding, the relationship between dental implants and the development of malignant lesions around them is not completely understood. It has been suggested that the titanium corrosion occurring at the top of dental implants causes the release of metal ions. These ions might lead to oral epithelial genetic damage and higher susceptibility of normal mucosa to malignant transformation. The aim of this chapter was to review the clinical characteristics, diagnosis, and the possible carcinogenic mechanisms involved in oral cancer around dental implants.

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“…CoCr nano-particles and Cr 3+ ions can trespass the cell membrane by diffusion or endocytosis, generating reactive oxygen and nitrogen species and disturbing the respiratory function of the cells. Submicron-(0.1-0.99 µm) and nano-scale particles are internalized by the cells via pinocytosis and phagocytosis processes of macrophages [93]. Also, the nano-scale debris and ions can reach the cell DNA inducing mutagenic reactions, as illustrated in Figure 3.…”

Section: Adverse Biological Effects Of Debris Released From Tmj Tjrmentioning

confidence: 99%

“…Nevertheless, inflammatory reactions were also reported for Ti, TiO 2 particles and Ti ions as found for CoCr-based debris. Additionally, the presence of V and Al ions has been associated with potential mutagenic and carcinogenic response [86,87,93]. The development of biocompatible titanium alloys, without potentially toxic elements like Al or V and the surface modification methods have been the targets for recent research.…”

Section: Adverse Biological Effects Of Debris Released From Tmj Tjrmentioning

confidence: 99%

A Preliminary Analysis of the Wear Pathways of Sliding Contacts on Temporomandibular Joint Total Joint Replacement Prostheses

Pinto-Borges

Carvalho

Henriques

et al. 2021

Metals

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In the last years, several materials and design have been assessed in an attempt to improve the mechanical performance of temporomandibular joint total joint replacement (TMJ TJR) prostheses. However, the wear of the TMJ TJR condyle to the polymer-based fossa component during loading and sliding movements. That promotes the release of debris and risks of toxicity to the surrounding tissues. The purpose of this study was to perform a narrative literature review on the wear of TMJ TJR sliding contacts and potential toxicity of metallic debris to the patients. Previous studies reported a significant deterioration of the sliding contact surfaces of TMJ TJR prostheses. Material loss as a result of wear can cause a TMJ TJR condyle/fossa mismatch and the modification of the contact pressure and chewing loading. As a further consequence of wear, metal particles are released to the surrounding tissues with a high risk of local tissue and systemic toxicity through the bloodstream. The presence of particles induces the stimulation of inflammatory reactions depending on the concentration and size of debris. Thus, CoCr-based condyle release metallic ions and sub-micron particles that can be engulfed by macrophages or internalized by other tissue cells. The wear and material loss of TMJ TJR could be decreased by design optimization and novel materials with low friction and contact pressure. That consequently decrease the amount of metallic ions and particles to the surrounding tissues, preventing peri-prosthetic inflammatory reactions.

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Cytotoxic effects of submicron- and nano-scale titanium debris released from dental implants: an integrative review

Cited by 47 publications

References 83 publications

An integrative review on the toxicity of Bisphenol A (BPA) released from resin composites used in dentistry

An integrative review on the toxicity of Bisphenol A (BPA) released from resin composites used in dentistry

Oral Cancer around Dental Implants: Are the Clinical Manifestations and the Oncogenic Mechanisms Unique?

A Preliminary Analysis of the Wear Pathways of Sliding Contacts on Temporomandibular Joint Total Joint Replacement Prostheses

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