Cytotoxic effects of Ammi visnaga volatile oil on some cancer cell lines

Mohammed, Zainab Y.; Nada, Saad M.; Al-Halbosiy, Mohammed M. F.; Abdulfattah, Shaimaa Y.; Abdul-Hameed, Bara’a

doi:10.24126/jobrc.2014.8.1.288

Cited by 8 publications

(1 citation statement)

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“…In the Phytochemical Screening, Antimicrobial an Antioxidant Activity of Ammi visnaga L. Extracts agricultural field, khella is also employed as both a herbicide and bactericide to protect plants [Khalil et al 2020;Iacobellis et al 2005]. Ammi visnaga L. has a well-established historical use in the medical field for the treating various diseases, including coronary heart disease [Khadhri et al 2011], nephritic disease [Vanachayangkul et al 2010;Alam et al 2018], angina pectoris, as well as for its antispasmodic, bronchial, and vasodilator asthma [Gunaydin and Beyazit 2004; Nada et al 2014]. Khella exhibits antioxidant, antibacterial, antifungal, and anticancer properties [Kamal et al 2022;Kooti et al 2017].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Antimicrobial and Antioxidant Activity of <i>Ammi visnaga</i> L. Extracts

Mgamat,

Haida,

Oubihi

et al. 2024

Ecol. Eng. Environ. Technol.

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Ammi visnaga L. extracts were examined for the presence of phytochemicals, antimicrobial activities, and scavenging potentials. The aerial part of this plant underwent warm extraction using three different solvents: hexane, dichloromethane and ethanol. The phytochemical analysis revealed the presence of polyphenols, tannins, flavonoids, glycosides, and reducing sugars in the ethanolic extract. In the dichloromethane extract, polyphenols and glycosides were identified, while in the hexane extract, polyphenols, flavonoids, and glycosides were detected. Antimicrobial activity was determined using disc diffusion method. Results indicate that the dichloromethane extract exhibited the largest zone of inhibition, measuring 10 mm against Staphylococcus aureus. The minimum inhibitory concentration (MIC) was recorded as 10 µL/mL, while the minimum bactericidal concentration (MBC) was below 10 µL/mL. However, no antimicrobial activity was observed against Klebsiella pneumoniae and Acinetobacter baumannii. Additionally, antioxidant activity was examined using the DPPH (2,2-diphenyl-1-picrylhydrazyle) assay. The ethanolic extract demonstrated the highest antioxidant power with an IC50 value of 0.843 ± 0.199 mg/ mL against 0.095 ± 0.009 mg/mL of ascorbic acid which is used as a reference.

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