Cytotoxic effect of trans-cinnamaldehyde on human leukemia K562 cells

Zhang, Jiahua; Liu, Li-qiong; He, Yanli; Kong, Weijia; Huang, Shiang

doi:10.1038/aps.2010.76

Cited by 48 publications

(34 citation statements)

References 22 publications

(20 reference statements)

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“…At IC 50 values similar to those found in our study, CAD and 2MOCA are inhibitors of NF-jB, a transcription factor involved in immunity as well as inflammatory responses and developmental processes (Reddy et al, 2004). In addition, 2MOCA and CAD up-regulate apoptosis in cancerous cell lines, and CAD has strong toxic effects in other mammalian cell types (Mereto et al, 1994;Stammati et al, 1999;Unlu et al, 2010;Zhang et al, 2010). In the current study, hESC were sensitive to low concentrations of CAD and 2MOCA, suggesting that pregnant women should be cautious using these products.…”

Section: Discussionsupporting

confidence: 85%

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids

Behar

Davis

Wang

et al. 2014

Toxicology in Vitro

218

211

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a b s t r a c tIn a prior study on electronic cigarette (EC) refill fluids, Cinnamon Ceylon was the most cytotoxic of 36 products tested. The purpose of the current study was to determine if high cytotoxicity is a general feature of cinnamon-flavored EC refill fluids and to identify the toxicant(s) in Cinnamon Ceylon. Eight cinnamon-flavored refill fluids, which were screened using the MTT assay, varied in their cytotoxicity with most being cytotoxic. Human embryonic stem cells were generally more sensitive than human adult pulmonary fibroblasts. Most products were highly volatile and produced vapors that impaired survival of cells in adjacent wells. Cinnamaldehyde (CAD), 2-methoxycinnamaldehyde (2MOCA), dipropylene glycol, and vanillin were identified in the cinnamon-flavored refill fluids using gas chromatography-mass spectrometry and high-pressure liquid chromatography (HPLC). When authentic standards of each chemical were tested using the MTT assay, only CAD and 2MOCA were highly cytotoxic. The amount of each chemical in the refill fluids was quantified using HPLC, and cytotoxicity correlated with the amount of CAD/ product. Duplicate bottles of the same product were similar, but varied in their concentrations of 2MOCA. These data show that the cinnamon flavorings in refill fluids are linked to cytotoxicity, which could adversely affect EC users.

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Section: Discussionsupporting

confidence: 85%

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids

Behar

Davis

Wang

et al. 2014

Toxicology in Vitro

218

211

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“…Ng and Wu reported that, compared with cinnamic acid and cinnamyl alcohol, cinnamaldehyde had more antiproliferative activity (18). Zhang et al reported that tr ans-cinnamaldehyde had cy totoxic activity on human leukemia K562 cells (19). Zhang et al, reported that apoptosis was one of the causes of cytotoxic effects of trans-cinnamaldehyde (19).…”

Section: Discussionmentioning

confidence: 99%

“…Zhang et al reported that tr ans-cinnamaldehyde had cy totoxic activity on human leukemia K562 cells (19). Zhang et al, reported that apoptosis was one of the causes of cytotoxic effects of trans-cinnamaldehyde (19). Furthermore, Lee et al, evaluated the anti-tumor effects of several cinnamaldehyde derivatives on SW620 human colon cancer cells.…”

Section: Discussionmentioning

confidence: 99%

C. zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (THP-1)

Assadollahi¹,

Gholami²,

Zendedel³

2015

BLL

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Abstract:Objective: The aim of this study was to evaluate the effect of C. zeylanicum aqueous extract on cell growth in the human myelocytic leukemia cell line (THP-1). Background: Today, application of Cinnamon for treatment of cancer investigates extensively. Cinnamon has antioxidant, anti-apoptotic and anti-infl ammatory properties. Methods: In this experimental study, THP-1 was incubated in 2, 1, 0.1 and 0.01 mg/ml C. zeylanicum solutions for 24, 48 and 72 hours. Cell cycle was assessed with fl ow cytometry. Apoptotic cells were identifi ed by Hoechst 33342 staining. Cell proliferation was assessed by the MTT assay. The data were analyzed using descriptive statistics and analytical tests. Results: Samples that supplemented with 0.1 mg/ml C. zeylanicum aqueous extract enhanced induction of apoptosis in THP-1 cell line compared to samples that supplemented with 2, 1 and 0.01 mg/ml. According to fl ow cytometry analysis, after 24 and 72 hours of incubation in 0.1 and 2 mg/ml C. zeylanicum aqueous extract, respectively, the amount of cells in apoptosis phase was higher than that in the control sample. Conclusion: Supplemented C. zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (Fig. 4, Ref. 20). Text in PDF www.elis.sk.

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“…In addition, cinnamaldehyde induces ROS‐mediated mitochondrial permeability transition and cytochrome C release, resulting in apoptosis of HL‐60 leukemia cells (Ka et al , ). Cinnamaldehyde also shows cytotoxic effects on leukemia K562 cells by decreasing mitochondrial transmembrane potential (Zhang et al ., ). In addition, cinnamon extracts induce G2/M cell cycle arrest in human leukemia CD45 Jurkat cells by modulating two signaling proteins, p38 MAPK and cyclin B, which regulate progression through the G2/M transition phase (Schoene et al ., ).…”

Section: Antitumor Effects Of Cinnamaldehyde In Different Types Of Camentioning

confidence: 97%

Cinnamaldehydes in Cancer Chemotherapy

Hong

Ismail

Kang

et al. 2016

Phytotherapy Research

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Cinnamaldehyde and cinnamaldehyde-derived compounds are candidates for the development of anticancer drugs that have received extensive research attention. In this review, we summarize recent findings detailing the positive and negative aspects of cinnamaldehyde and its derivatives as potential anticancer drug candidates. Furthermore, we describe the in vivo pharmacokinetics and metabolism of cinnamaldehydes. The oxidative and antioxidative properties of cinnamaldehydes, which contribute to their potential in chemotherapy, have also been discussed. Moreover, the mechanism(s) by which cinnamaldehydes induce apoptosis in cancer cells have been explored. In addition, evidence of the regulatory effects of cinnamaldehydes on cancer cell invasion and metastasis has been described. Finally, the application of cinnamaldehydes in treating various types of cancer, including breast, prostate, and colon cancers, has been discussed in detail. The effects of cinnamaldehydes on leukemia, hepatocellular carcinoma, and oral cancer have been summarized briefly. Copyright © 2016 John Wiley & Sons, Ltd.

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Cytotoxic effect of trans-cinnamaldehyde on human leukemia K562 cells

Cited by 48 publications

References 22 publications

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids

C. zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (THP-1)

Cinnamaldehydes in Cancer Chemotherapy

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