Cinnamaldehydes in Cancer Chemotherapy

Hong, Sangjin; Ismail, Ismail Ahmed; Kang, Sung-Min; Han, Dong Cho; Kwon, Byoung‐Mog

doi:10.1002/ptr.5592

Cited by 88 publications

(58 citation statements)

References 96 publications

(143 reference statements)

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“…Our data show that HCA also inhibits the STAT3 activity by directly binding to STAT3 (Figures C and ). Furthermore, preclinical evaluations of HCA show that HCA is a safe and potent anticancer agent . Therefore, our results suggest that HCA could be a potent anticancer agent targeting STAT3‐activated tumor cells.…”

Section: Discussionmentioning

confidence: 65%

“…Data represent mean ± SD and potent anticancer agent. 19 Therefore, our results suggest that HCA could be a potent anticancer agent targeting STAT3-activated tumor cells.…”

Section: Discussionmentioning

confidence: 67%

“…2′‐Hydroxycinnamaldehyde (HCA), isolated from stem bark of Cinnamomum cassia , is reported as an anticancer agent with inhibitory effects on farnesyl protein transferase . HCA and its derivative 2′‐benzyoyl‐oxycinnamaldehyde (BCA) exhibit anti‐tumor activities in various types of cancer cells . HCA inhibits cell proliferation and tumor growth by regulating transcription activity and signal transduction .…”

Section: Introductionmentioning

confidence: 99%

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2′‐Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation

et al. 2018

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Inhibition of the signal transducer and activator of transcription 3 (STAT3) signaling pathway is a novel therapeutic strategy to treat human cancers with constitutively active STAT3. During the screening of natural products to find STAT3 inhibitors, we identified 2′‐hydroxycinnamaldehyde (HCA) as a STAT3 inhibitor, which was isolated from the stem bark of Cinnamomum cassia. In this study, we found that HCA inhibited constitutive and inducible STAT3 activation in STAT3‐activated DU145 prostate cancer cells. HCA selectively inhibited the STAT3 activity by direct binding to STAT3, which was confirmed by biochemical methods, including a pull‐down assay with biotin‐conjugated HCA, a drug affinity responsive target stability (DARTS) experiment and a cellular thermal shift assay (CETSA). HCA inhibited STAT3 phosphorylation at the tyrosine 705 residue, dimer formation, and nuclear translocation in DU145 cells, which led to a downregulation of STAT3 target genes. The downregulation of cell cycle progression and antiapoptosis‐related gene expression by HCA induced the accumulation of cells in the G0/G1 phase of the cell cycle and then induced apoptosis. We also found that reactive oxygen species (ROS) were involved in the HCA‐induced inhibition of STAT3 activation and cell proliferation because the suppressed p‐STAT3 level was rescued by glutathione or N‐acetyl‐L‐cysteine treatment, which are general ROS inhibitors. These results suggest that HCA could be a potent anticancer agent targeting STAT3‐activated tumor cells.

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Section: Discussionmentioning

confidence: 65%

“…Data represent mean ± SD and potent anticancer agent. 19 Therefore, our results suggest that HCA could be a potent anticancer agent targeting STAT3-activated tumor cells.…”

Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

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2′‐Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation

et al. 2018

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“…However, as the concentration within the fibres increases from 6 to 12 g/24 mL, there is enhanced potency in the anti‐fungal activity as confirmed by larger inhibition areas (722 ± 32 and 873 ± 39 mm 2 , respectively). Extracts of cinnamon contain several active compounds including cinnamaldehyde and tannins . Tannins are known to inhibit growth of certain bacterial strains such as Staphylococcus aureus .…”

Section: Discussionmentioning

confidence: 99%

Anti‐fungal bandages containing cinnamon extract

Ahmed

Altun

Aydoğdu

et al. 2019

International Wound Journal

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Cinnamon‐containing polycaprolactone (PCL) bandages were produced by pressurised gyration and their anti‐fungal activities against Candida albicans were investigated. It was found that by preparing and spinning polymer solutions of cinnamon with PCL, fibres capable of inhibiting fungal growth could be produced, as observed in disk diffusion tests for anti‐fungal susceptibility. Fascinatingly, compared with raw cinnamon powder, the novel cinnamon‐loaded fibres had outstanding long‐term activity. The results presented here are very promising and may indeed accelerate a new era of using completely natural materials in biomedical applications, especially in wound healing.

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“…Traditional Chinese medicine provides a rich resource in the search for novel anticancer agents, of which caper euphorbia seed has been recorded for treating cancer 4 . The genus Euphorbia (spurges, Euphorbiaceae) has received worldwide attention as its exceptional diversity of growth forms and near-worldwide distribution 5 .…”

Section: Introductionmentioning

confidence: 99%

Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway

Lin

Tang

Zhang

et al. 2017

Acta Pharmaceutica Sinica B

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Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. This article focuses on the cytotoxic activity of Euphorbia factor L2 against lung carcinoma A549 cells and the mechanism by which apoptosis is induced. We analyzed the cytotoxicity and related mechanism of Euphorbia factor L2 with an MTT assay, an annexin V-FITC/PI test, a colorimetric assay, and immunoblotting. Euphorbia factor L2 showed potent cytotoxicity to A549 cells. Euphorbia factor L2 led to an increase in reactive oxygen species (ROS) generation, a loss of mitochondrial electrochemical potential, release of cytochrome c, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase, suggesting that Euphorbia factor L2 induced apoptosis through a mitochondrial pathway. The cytotoxic activity of Euphorbia factor L2 in A549 cells and the related mechanisms of apoptotic induction provide support for the further investigation of caper euphorbia seeds.

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Cinnamaldehydes in Cancer Chemotherapy

Cited by 88 publications

References 96 publications

2′‐Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation

2′‐Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation

Anti‐fungal bandages containing cinnamon extract

Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway

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