Cytotoxic Effect of Chitosan Based Nanocomposite Synthesized by Radiation: In Vitro Liver and Breast Cancer Cell Line

Abaza, A.; Mahmoud, Ghada A.; Hegazy, El‐Sayed A.; Amin, Muhammad; Shoukry, Eman M.; Elsheikh, B.

doi:10.17265/2328-2150/2018.04.002

Cited by 7 publications

(8 citation statements)

References 29 publications

(35 reference statements)

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“…Bhatnagar et al 68 showed that SNPs fabricated using extracellular pigment from Talaromyces purpurogenus have a significant cytotoxicity effect against liver cancer cell line. Abaza et al 69 showed that Cs/PVA/Ag nanocomposites caused in killing 50% of HepG2 cells at 43.7 µg/mL. Based on these data, D-SNPs may be a potent antitumor agent against HepG2 with low IC 50 .…”

Section: Resultsmentioning

confidence: 97%

“…Martins et al 72 showed that a polyelectrolyte complex containing SNPs exerted cytotoxic effects against Caco-2 cells, but not healthy African green monkey cells (VERO cells), at concentrations above 100 µg/mL. Comparing the chemically synthesized SNPs, 69,72 D-SNPs showed a potent anticancer activity with low IC 50 values and may be an alternative material to treat cancer.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria Desertifilum sp. extract: Their Antibacterial and Cytotoxicity Effects

Hamida

Abdelmeguid

Ali

et al. 2020

IJN

116

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Background: The emergence of multi drug-resistant (MDR) bacterial infections and cancer has necessitated the development and discovery of alternative eco-safe antibacterial and anticancer agents. Biogenic fabrication of metallic nanoparticles is an emerging discipline for production of nanoproducts that exert potent anticancer and antibacterial activity, and do not suffer from the limitations inherent in physiochemical synthesis methods. Methodology: In this study, we isolated, purified, and characterized a novel cyanobacteria extract (Desertifilum IPPAS B-1220) to utilize in biofabrication of silver nanoparticles (D-SNPs). D-SNPs were produced by adding Desertifilum extract to silver nitrate solution under controlled conditions. Biofabrication of D-SNPs was confirmed using a UV-Vis spectrophotometer. The resultant D-SNPs were characterized using XRD, FTIR, SEM, and TEM. The toxicity of D-SNPs against five pathogenic bacteria and three cancer cell lines (MCF-7, HepG2, and Caco-2) was evaluated. Results: Formation of D-SNPs was indicated by a color change from pale yellow to dark brown. The peak of the surface plasmon resonance of the D-SNPs was at 421 nm. The XRD detected the crystallinity of D-SNPs. FTIR showed that polysaccharides and proteins may have contributed to the biofabrication of D-SNPs. Under SEM and TEM, the D-SNPs were spherical with diameter ranges from 4.5 to 26 nm. The D-SNPs significantly suppressed the growth of five pathogenic bacteria, and exerted cytotoxic effects against MCF-7, HepG2, and Caco-2 cancer cells with IC 50 values of 58, 32, and 90 µg/mL, respectively. Conclusion: These findings showed for the first time the potentiality of novel cyanobacteria strain Desertifilum IPPAS B-1220 to fabricate small SNPs that acted as potent anticancer and antibacterial material against different cancer cell lines and pathogenic bacterial strains. These findings encourage the researchers to focus on cyanobacteria in general and especially Desertifilum sp. IPPAS B-1220 for synthesizing different NPs that opening the window for new applications.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria Desertifilum sp. extract: Their Antibacterial and Cytotoxicity Effects

Hamida

Abdelmeguid

Ali

et al. 2020

IJN

116

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“…The estimated half maximal inhibitory concentration (IC50) value was found to be 31.2 μg/mL. Abaza et al [22] in 2018 reported the percentage of inhibiting fraction of Cs/PVA/AgNP in MCF7 cell line at 100 ug/mL was 61.8% and 80% with IC50 value of 60 and 52.5 μg/mL in (1:9) and (4:6) concentration respectively. The expected mechanism of AgNP induced toxicity being in the interactions between nanomaterials and cells [42].…”

Section: Resultsmentioning

confidence: 98%

“…Patil and his colleague [1] also, observed 50% of cell inhibition at AuNPs concentration of approximately 150 μg/mL and the 200 μg/mL sample reduced all cells to around 20% viability. On the other hand, Abaza et al [22] in 2018 reported that the silver-doped chitosan-poly (vinyl alcohol) (Cs/PVA/AgNP) inhibition fraction of HepG2 cell proliferation at 50 ug/mL in concentration of (4:6) and (1:9) was 54.4% and 40.8 respectively. The IC 50 value of concentration (4:6) was 43.7 µg/mL.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Gold Nanocomposite on the Cytotoxicity of Human Cancer Cell Lines

Abaza¹,

Mahmoud²,

Elsheikh³

2018

JPP

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Gold nanoparticles (AuNPs) have a biological property that have attracted significant attention in this decade, especially in the field of biomedical application with great therapeutic potential. Additionally, the chitosan molecule appears to be a suitable polymeric complex used in this field. The aim of the current study is to explores the cytotoxicity and the IC 50 value of Au-doped chitosan-poly (vinyl alcohol) (Cs/PVA/Au) nanocomposite that was developed by gamma irradiation with promising anticancer activity. The anti-cancer activity of the prepared nanocomposites was demonstrated in human liver cancer cell line HEPG2 and MCF7 breast cancer cell lines. It has significant effects against both cancer cell line. Concluding that, the future nanomedicine will be impacted greatly by the collaboration of biomedical research and developing nanoparticle therapy in the right directions, which will improve the outcome of cancer patients. It is expected that the next decade will reveal real potential for metal nanoparticles to cross the regulatory barrier into clinical use as effective therapeutics.

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Synthesis of Hybrid Chitosan Silver Nanoparticles Loaded with Doxorubicin with Promising Anti-cancer Activity

Mohamed

2020

BioNanoSci.

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Cytotoxic Effect of Chitosan Based Nanocomposite Synthesized by Radiation: In Vitro Liver and Breast Cancer Cell Line

Cited by 7 publications

References 29 publications

<p>Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria <em>Desertifilum</em> sp. extract: Their Antibacterial and Cytotoxicity Effects</p>

<p>Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria <em>Desertifilum</em> sp. extract: Their Antibacterial and Cytotoxicity Effects</p>

Effect of Gold Nanocomposite on the Cytotoxicity of Human Cancer Cell Lines

Synthesis of Hybrid Chitosan Silver Nanoparticles Loaded with Doxorubicin with Promising Anti-cancer Activity

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