Cytotoxic effect of antisera on <sup>51</sup>Cr‐labelled monolayers of skeletal muscle

Dawkins, Roger L.; Loewi, G.

doi:10.1002/path.1711100108

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…Critical reviews of' EAM have been p~b l i s h e d .~~,~~~ Early attempts to produce EAM induced adjuvant arthritis,153 which may interfere with observations on EAM. EAM has been reported to follow the injection of homologous muscle into guinea pig^,'^',^^^ rabbits,lB4 and rats.136 More extensive studies have been conducted with heterologous muscle, usually derived from rabbit, injected into guinea pigs4S, 48,118,173,195 or rats. 63 There also has been the reported success of homologous cardiac muscle used for the induction of EAM in guinea pigs.Ig2 The numerous studies that have been performed may be interpreted to indicate the following:…”

Section: Experimental Mvosltlsmentioning

confidence: 99%

Inflammatory myopathy: A review of etiologic and pathogenetic factors

Whitaker

1982

Muscle and Nerve

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Human idiopathic inflammatory myopathy is an acquired disorder with an annual incidence of two to five cases per million. A genetic influence on host susceptibility may also play a role. With the marked heterogeneity of the disease one of the major challenges is to identify subsets that might share a more uniform pathogenesis and manifest a less diverse profile of clinical findings, histopathological abnormalities, and natural history. Dermatomyositis can be distinguished by clinical appearance and pathological changes, but the recognition of additional disease subsets remains very inexact. Current evidence suggests that dermatomyositis occurs as a result of a vasculopathy, but immune mechanisms involved in other categories of idiopathic inflammatory myopathy may also involve cell-mediated immunity and possibly multiple mechanisms. Even though viral-induced muscle inflammation occurs in humans, there is no convincing evidence for a viral cause of idiopathic inflammatory myopathy. Experimental allergic myositis may be produced by the injection of animals with skeletal muscle homogenates and complete Freund's adjuvant, but the myositogenic factor is unknown and the parallels between experimental allergic myositis and human idiopathic inflammatory myopathy are limited.

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Section: Experimental Mvosltlsmentioning

confidence: 99%

Inflammatory myopathy: A review of etiologic and pathogenetic factors

Whitaker

1982

Muscle and Nerve

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Cell-Mediated Cytotoxicity and Childhood Dermatomyositis

Iannaccone¹,

Bowen²,

Samaha³

1982

Archives of Neurology

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Experimental allergic myositis in SJL/J mice immunized with rabbit myosin B fraction: immunohistochemical analysis and transfer

1993

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Experimental allergic myositis (EAM) was produced in SJL/J mice by inoculation with the myosin B fraction of the rabbit skeletal muscle, and the pathological changes were quantified. The myosin B fraction contains actin, myosin, tropomyosin and many other proteins, and has been known to induce severe EAM in guinea pigs. In the present model, macrophages and CD4+ lymphocytes predominated among the infiltrating cells. On the surface of muscle fibers and in the regions of cell infiltration deposition of the immunoglobulin G (IgG) and complement factor 3 was observed. EAM was transferred to normal mice by injecting the serum IgG of EAM. Depleting the recipients of complement before the transfer resulted in less-severe pathological changes. Morphologically, the EAM IgG showed an affinity for the nuclei, myofilaments, sarcolemma and blood vessels of mouse skeletal muscle. Biochemically EAM IgG contained antibodies against myosin, actin, troponin, M protein and other muscle proteins. These results indicated that IgG and complement play important roles in this model.

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Cytotoxic effect of antisera on ⁵¹Cr‐labelled monolayers of skeletal muscle

Cited by 5 publications

References 12 publications

Inflammatory myopathy: A review of etiologic and pathogenetic factors

Inflammatory myopathy: A review of etiologic and pathogenetic factors

Cell-Mediated Cytotoxicity and Childhood Dermatomyositis

Experimental allergic myositis in SJL/J mice immunized with rabbit myosin B fraction: immunohistochemical analysis and transfer

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Cytotoxic effect of antisera on 51Cr‐labelled monolayers of skeletal muscle

Cited by 5 publications

References 12 publications

Inflammatory myopathy: A review of etiologic and pathogenetic factors

Inflammatory myopathy: A review of etiologic and pathogenetic factors

Cell-Mediated Cytotoxicity and Childhood Dermatomyositis

Experimental allergic myositis in SJL/J mice immunized with rabbit myosin B fraction: immunohistochemical analysis and transfer

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Cytotoxic effect of antisera on ⁵¹Cr‐labelled monolayers of skeletal muscle