Cell-Mediated Cytotoxicity and Childhood Dermatomyositis

Iannaccone, Susan T.; Bowen, Donna; Samaha, Frederick J.

doi:10.1001/archneur.1982.00510190018005

Archives of Neurology

1982

DOI: 10.1001/archneur.1982.00510190018005

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Cell-Mediated Cytotoxicity and Childhood Dermatomyositis

Susan T. Iannaccone¹,

Donna Bowen²,

Frederick J. Samaha³

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1984

2003

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Cited by 13 publications

(3 citation statements)

References 29 publications

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“…In muscle biopsy samples, the presence of a perivascular mononuclear cell infiltrate, including CD4-positive and CD8-positive T lymphocytes and macrophages, has been documented (2,3). Peripheral blood lymphocytes from patients with inflammatory myopathies, including juvenile DM, have been shown to cause muscle-specific injury in cytotoxicity assays (4)(5)(6). Lymphocytes from patients with inflammatory myopathies incubated with autologous muscle were shown to produce a "lymphotoxin" that caused muscle necrosis and impaired protein synthesis (7).…”

mentioning

confidence: 99%

Self epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositis

Massa

Costouros

Mazzoli

et al. 2002

Arthritis & Rheumatism

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Objective. To identify self T cell epitopes associated with proinflammatory immune responses and clinically active juvenile dermatomyositis (juvenile DM). The target of our search for relevant epitopes was represented by amino acid sequences shared between human skeletal myosin and Streptococcus pyogenes M5 protein. The long-term objective of the project is to identify suitable targets for immunotherapy of the disease.Methods. We used computerized algorithms to identify putative agretopes on both the human myosin and Streptococcus M5 proteins. Direct binding assays for homolog peptides were used to confirm such predictions. Antigenicity and functional cross-reactivity were evaluated by cytotoxicity assays and by measurement of cytokine levels. Specific T cells were isolated by T cell capture, and T cell receptor (TCR) V ␤ gene usage was identified by reverse transcriptase-polymerase chain reaction.Results. We identified peptides that are targets of disease-specific cytotoxic T cell responses. T cell reactivity against the self peptides correlates with clinical signs of early, active myositis. Such reactivity is accompanied by production of proinflammatory cytokines, which may contribute to the damage. T cell crossrecognition of bacterial and human homologs was shown functionally as well as by sorting peptide-specific T cells and identifying oligoclonal and largely overlapping TCR V ␤ gene usage.Conclusion. These findings represent the first identification of a self epitope in juvenile DM, providing a potential candidate for antigen-specific immune therapy.

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mentioning

confidence: 99%

Self epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositis

Massa

Costouros

Mazzoli

et al. 2002

Arthritis & Rheumatism

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“…3 We now show that a similar system can be used to test several cellular and soluble fac¬ tors for cytotoxic effects against endothelium in culture. 3 We now show that a similar system can be used to test several cellular and soluble fac¬ tors for cytotoxic effects against endothelium in culture.…”

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confidence: 92%

In Vitro Study of Cytotoxic Factors Against Endothelium in Childhood Dermatomyositis

Iannaccone¹,

Bowen²,

Yarom³

et al. 1984

Archives of Neurology

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“…In muscle biopsy samples, the presence of a perivascular mononuclear cell infiltrate, including CD4‐positive and CD8‐positive T lymphocytes and macrophages, has been documented (2, 3). Peripheral blood lymphocytes from patients with inflammatory myopathies, including juvenile DM, have been shown to cause muscle‐specific injury in cytotoxicity assays (4–6). Lymphocytes from patients with inflammatory myopathies incubated with autologous muscle were shown to produce a “lymphotoxin” that caused muscle necrosis and impaired protein synthesis (7).…”

mentioning

confidence: 99%

Effect of surface‐grafted ionic groups on the performance of cellulose‐fiber‐reinforced thermoplastic composites

Cai

Riedl

Aı̈t-Kadi

2003

J Polym Sci B Polym Phys

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The influence of the surface chemistry of the cellulose fiber and polymer matrix on the mechanical and thermal dynamic mechanical properties of cellulose‐fiber‐reinforced polymer composites was investigated. The cellulose fiber was treated either with a coupling agent or with a coupling‐agent treatment followed by the introduction of quaternary ammonium groups onto the fiber surface, whereas the polymer matrix, with opposite polar groups such as polystyrene incorporated with sulfonated polystyrene and poly(ethylene‐co‐methacrylic acid), was compounded with the fiber. The grafting of the fiber surface was investigated with Fourier transform infrared spectroscopy and X‐ray photoelectron spectroscopy. Experimental results showed that an obvious improvement in the mechanical strength could be achieved for composites with an ionic interface between the fiber and the polymer matrix because of the adhesion enhancement of the fiber and the matrix. The improved adhesion could be ascribed to the grafted ionic groups at the cellulose‐fiber surface. © 2003 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 41: 2022–2032, 2003

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Cell-Mediated Cytotoxicity and Childhood Dermatomyositis

Cited by 13 publications

References 29 publications

Self epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositis

Self epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositis

In Vitro Study of Cytotoxic Factors Against Endothelium in Childhood Dermatomyositis

Effect of surface‐grafted ionic groups on the performance of cellulose‐fiber‐reinforced thermoplastic composites

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