Cytotoxic Constituents from the Vietnamese Fungus <i>Xylaria schweinitzii</i>

Linh, Doan Thi Phuong; Hiền, Bùi Thị Thu; Que, Do Due; Lam, Duong Minh; Arnold, Norbert; Schmidt, Jürgen; Porzel, Andrea; Quang, Đặng Ngọc

doi:10.1177/1934578x1400900518

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…Cultures of Xylariaceae either isolated as endophytes or derived from ascospores have proved to be an rich source for bioactive natural products. Among those are the insecticidal nodulisporic acids (Bills et al, 2012), the antifungal agents hypoxysordarin (Daferner et al, 1999) and sporothriolide , the cytotoxic schweinitzin A (Linh et al, 2014), antimalarial eremophilanes (Isaka et al, 2010), the protein kinase B inhibitor haloroquinone (Niu et al, 2012), the antibacterial hypocoprins (Jayanetti et al, 2014), and the antioxidative daldinan A (Lee et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Rickenyls A–E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota)

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Rickenyls A–E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota)

et al. 2015

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“…Curtis. Compound 309 exhibited cytotoxicity against KB, Hep-G2, human lung adenocarcinoma (SK-Lu-1), and MCF-7 cell lines with IC 50 values of 0.72, 2.13, 2.32, and 4.09 μg/mL, respectively [ 107 ]. Two new polyketides, including 6-ethyl-8-hydroxy-4H-chromen-4-one ( 311 ) and 6-ethyl-7,8-dihydroxy-4H-chromen-4-one ( 312 ), were isolated from the fungus Xylaria sp.…”

Section: Structural and Biological Activity Studiesmentioning

confidence: 99%

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

Chen,

Yu,

Chen

et al. 2024

JoF

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The fungus genus Xylaria is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of Xylaria spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review. Remarkably, among these compounds, 177 compounds show various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, immunosuppressive, and enzyme-inhibitory activities. This paper will guide further investigations into the structures of novel and potent active natural products derived from Xylaria and their potential contributions to the future development of new natural drug products in the agricultural and medicinal fields.

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“…Agglutinin from Paecilomyces japonica also exerts cytotoxic effects on human breast cancer MDA-MB-231 cells, human pancreas cancer AsPc-1 cells, and stomach cancer SNU-1 cells 162 . Pigments derived from Daldinia concentrica 163 and Xylaria schweinitzii 164 also present cytotoxicity against lung carcinoma SK-LU-I cells, hepatocellular carcinoma HepG2 cells, epidermal carcinoma KB cells, and breast carcinoma MCF7 cells. Lectins derived from Hericium erinaceum 165 , Russula delica 166 , Russula lepida 167 , and laccase derived from Tricholoma mongolicum 168 can suppress the proliferation of HepG2 hepatoma cells and MCF7 breast cancer cells.…”

Section: Applications Of Microorganisms Used In Cancer Theranosticsmentioning

confidence: 99%

Emulating interactions between microorganisms and tumor microenvironment to develop cancer theranostics

Jiang¹,

Yang²,

Chen³

et al. 2022

Theranostics

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The occurrence of microorganisms has been confirmed in the tumor microenvironment (TME) of many different organs. Microorganisms (e.g., phage, virus, bacteria, fungi, and protozoa) present in TME modulate TME to inhibit or promote tumor growth in species-dependent manners due to the special physiological and pathological features of each microorganism. Such microorganism-TME interactions have recently been emulated to turn microorganisms into powerful cancer theranostic agents. To facilitate scientists to explore microorganisms-TME interactions further to develop improved cancer theranostics, here we critically review the characteristics of different microorganisms that can be found in TME, their interactions with TME, and their current applications in cancer diagnosis and therapy. Clinical trials of using microorganisms for cancer theranostics are also summarized and discussed. Moreover, the emerging technology of whole-metagenome sequencing that can be employed to precisely determine microbiota spectra is described. Such technology enables scientists to gain an in-depth understanding of the species and distributions of microorganisms in TME. Therefore, scientists now have new tools to identify microorganisms (either naturally present in or introduced into TME) that can be used as effective probes, monitors, vaccines, or drugs for potentially advancing cancer theranostics to clinical applications.

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Cytotoxic Constituents from the Vietnamese Fungus Xylaria schweinitzii

Cited by 8 publications

References 7 publications

Rickenyls A–E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota)

Rickenyls A–E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota)

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

Emulating interactions between microorganisms and tumor microenvironment to develop cancer theranostics

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