Cytotoxic Constituents from Podocarpus fasciculus

Chemical constituents from the roots and stems of Stauntonia brachyanthera Hand-Mazz and their bioactivities

“…Even so, this also made a difference in effect on cytotoxicity. That is, the number of catechol moieties along with methoxy substituents and the existence and positions of the conjugated substituents on the glucose ring have influence on the compounds' cytotoxicity in different degrees (Kaur et al, 2002;Kuo et al, 2008;Lee et al, 2007). Otherwise, rhamnose group is also supposed to be an important anticancer feature of phenylpropanoid structure (Lee et al, 2007) which can be presented by compound 1.…”

Mutagenicity, antimutagenicity and cytotoxicity evaluation of South African Podocarpus species

“…Flavonoids are also known to cause cytotoxic effects on malignant cells in culture (Saeki et al, 1999). The presence of methoxyl and hydroxyl groups in biflavonoids isolated from species of Podocarpus play an important role in mediating cytotoxic effects (Kuo et al, 2008).…”

Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South Africa

“…These are the ortho-dihydroxy group in the Bring, the conjugation of the B-ring to the 4-oxo group via C2-C3 double bond and the 3-and 5-OH groups with the 4-oxo group (Bors et al, 1990). These structural features have been identi- fied in a number of flavonoids isolated from several species of Podocarpus (Markham et al, 1985;Kuo et al, 2008). Flavonoids and flavones derivatives are known to modulate pro-inflammatory gene expression such as inducible nitric oxide synthesis and COX-2.…”