Cytotoxic, antioxidant and antibacterial activities of Varthemia iphionoides Boiss. extracts

Al-Dabbas, Maher M.; Suganuma, Toshihiko; Kitahara, Kuninori; Hou, De‐Xing; Fujii, Makoto

doi:10.1016/j.jep.2006.05.006

Cited by 48 publications

(23 citation statements)

References 32 publications

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“…Results of this study were shown in Table 1. It has been reported elsewhere that aqueous extract of Varthemia iphionoides has a high content of phenolic compounds and flavonoids (Al-Dabbas et al, 2006). This might explain its antibacterial activity and emphasize their earlier use for treatment of infections (Jabour, 1983;Karim and Quraan, 1986).…”

Section: Discussionmentioning

confidence: 90%

The Antimicrobial Activity of <i>Aliquidambar orientalis</i> mill. Against Food Pathogens and Antioxidant Capacity of Leaf Extracts

Ökmen¹,

Türkcan²,

Ceylan³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Medicinal plants are an important source of substances which are claimed to induce antimicrobial, antimutagenic and antioxidant effects. Many plants have been used due to their antimicrobial treatments. Antimicrobial and antioxidant activities of L. orientalis have not been reported to the present day. The aim of this work was to investigate of the antimicrobial and antioxidant potentials of different extracts from L. orientalis. Materials and Methods: The extracts were screened for antimicrobial activity against different food pathogens. These bacteria include 4 Gram positive and 3 Gram negative bacteria and one fungi. The leaf extracts of plant were tested by disc diffusion assay. The MIC was evaluated on plant extracts as antimicrobial activity. In addition to, the plant extracts were tested against the stable DPPH (2,2-diphenyl-1-picryl-hydrazylhydrate) free-radical. Results: The acetone, ethanol and methanol extracts of L. orientalis showed maximum inhibition zone of 12 mm against Yersinia enterocolitica, Listeria monocytogenes and Staphylococcus aureus. In addition to, the methanol extract displayed a strong antioxidant activity (trolox equivalent = 2.23 mM). Conclusion: L. orientalis extracts have antimicrobial, and antioxidant potential. Our results support the use of this plant in traditional medicine and suggest that some of the plant extracts possess compounds with good antibacterial properties that can be used as antibacterial agents in the search for new drugs.

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Section: Discussionmentioning

confidence: 90%

The Antimicrobial Activity of <i>Aliquidambar orientalis</i> mill. Against Food Pathogens and Antioxidant Capacity of Leaf Extracts

Ökmen¹,

Türkcan²,

Ceylan³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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“…Total flavonoid content was measured according to Al-Dabbas, Kanefumi, Hou, and Fujii (2006). 1.5 mL of the extract was mixed with 2% AlCl 3 .…”

Section: Total Phenolic and Flavonoid Contentsmentioning

confidence: 99%

Phytochemical investigation of Tunisian Salicornia herbacea L., antioxidant, antimicrobial and cytochrome P450 (CYPs) inhibitory activities of its methanol extract

Essaidi¹,

Brahmi²,

Snoussi³

et al. 2013

Food Control

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“…Many phenol substances of plant origin or synthetic products and some salicylic acid derivatives as aspirin exhibit certain antioxidant and antiproliferative activities. [3][4][5][6][7][8][9][10][11][12][13][14] Bearing the above in mind, one part of the present research was directed to the microwaveinduced synthesis of some new derivatives of salicylic acid, starting from different amino alcohols, diamines and diols, as well as to the determination of their antioxidant and antiproliferative activities. Microvawe irradiation is an alternative to conventional heating for introducing energy into reactions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of some new 2-oxazoline and salicylic acid derivatives

Djurendić¹,

Vujašković²,

Sakač³

et al. 2010

Arkivoc

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Starting from methyl salicylate and 2-amino-2-(hydroxymethyl)propane-1,3-diol 1a, or 2-amino-2-methylpropane-1-ol 1b, the 2-oxazoline derivatives 2a, 2b or 3, as well as mono-4a and 4b and bis-5a and 5b derivatives of salicylic acid were synthesized. Reactions were performed by microwave irradiation in the presence of tetrabutylammonium bromide or metallic sodium as catalyst, as well as by conventional heating. Microwave-induced reaction of some diols, diamines and amino alcohols with methyl salicylate gave mono-and/or bis-derivatives of salicylic acid 4c, 5c, 5d, 6c, 8c, 7a, 7b, 8a and 8b. The mono-and bis-salicyloyl derivatives 4c, 5c and 5d were transformed to the corresponding phenyl-azo derivatives 9, 10c and 10d. The structure of compound 3 was proved by the X-ray analysis and the R-configuration on its stereocenter was confirmed. The antioxidant and cytotoxic activities of the synthesized derivatives were evaluated in a series of in vitro tests. Compounds 5d, 8b and 8c exhibited very strong activity against hydroxyl radical. Six 4c, 5d, 8a-c, 10c of 16 tested compounds inhibited growth of MDA-MB-231 cells at a nanomolar concentration. Compounds 8c and 10c showed high cytotoxicity against MCF7 cells, whereas compounds 4c, 5d, 8a-c and 10d showed high activity against K562 cells.

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Cytotoxic, antioxidant and antibacterial activities of Varthemia iphionoides Boiss. extracts

Cited by 48 publications

References 32 publications

The Antimicrobial Activity of <i>Aliquidambar orientalis</i> mill. Against Food Pathogens and Antioxidant Capacity of Leaf Extracts

The Antimicrobial Activity of <i>Aliquidambar orientalis</i> mill. Against Food Pathogens and Antioxidant Capacity of Leaf Extracts

Phytochemical investigation of Tunisian Salicornia herbacea L., antioxidant, antimicrobial and cytochrome P450 (CYPs) inhibitory activities of its methanol extract

Synthesis and biological evaluation of some new 2-oxazoline and salicylic acid derivatives

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