Cytotoxic and mutagenic effects of dental composite materials

The influence of some iatrogenic factors on a cytomorphometric analysis of gingival cells and periodontal status among diabetic patients

“…In the comparison with the cytological samples of metal ceramic crowns of the current study there were percentage of apoptotic cells caused by composite filling and this is in agreement with Samuelsen et al 28 and Schweikl et al 29 . This effect may be due to an increase the duration of composite resin fillings (more than 1week) that induced an elevation of the monomer transformation rate based on the chemical nature of these materials and also there was an increase in the dimethacrylates cytotoxicity after more than (72hr) where the treated cell cultures could not able to modify their form that were destroyed cells 29 .…”

“…This effect may be due to an increase the duration of composite resin fillings (more than 1week) that induced an elevation of the monomer transformation rate based on the chemical nature of these materials and also there was an increase in the dimethacrylates cytotoxicity after more than (72hr) where the treated cell cultures could not able to modify their form that were destroyed cells 29 . Furthermore, there were a toxic product generation like methacrylic acid (MA) due to the effect of enzymatic hydrolysis (by esterases) on composite resins 30,31 .…”

In VitroComparison of the Effects of Dental Filling Materials on Mouse Fibroblasts

“…Such leaching may cause adverse effects (11). In vitro and in vivo studies have clearly identified that some components of restorative materials are Periodontologist in private practice, Kayseri, Turkiye cytotoxic (22,31,51,54). The reviewed studies indicate that the cytotoxicity levels of resin-based restorative materials vary according to their chemical composition, leaching medium, and the amount and type of the components that can be extracted from the materials (12).…”

Adhesion of Streptococcus sanguinis to Dental Implant and Restorative Materials in vitro

“…Although these materials are safe and effective for their intended use 6) , there is also an increasing interest in dental materials which minimize plaque formation 7) .…”

“…The supernatant was filtered through two lowprotein-binding filters (pore sizes of 0.45 m and 0.22 m; Millex-HV and Millex-GV respectively, Millipore, Switzerland) connected in series. Sterilized saliva was stored at 6 and processed within two days. Before use, the pH was adjusted to 7.1 7.3 with phosphate buffer (0.067 mol/l Na2HPO4, 0.067 mol/l KH2PO4).…”