Cytotoxic and genotoxic effects of Lavandula stoechas aqueous extracts

Çelik, Tülay Aşkın; Aslantürk, Özlem Sultan

doi:10.2478/s11756-007-0051-2

Cited by 71 publications

(45 citation statements)

References 27 publications

(24 reference statements)

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“…The cytotoxic effects of plant extracts and essential oils can be evaluated through various cytogenetic assays, including the straightforward and relatively inexpensive root-tip assays (Sobita & Bhagirath 2005;Kuras et al 2006;Akinboro & Bakare 2007;Celik & Aslanturk 2007;Sousa et al 2009;Sousa & Viccini 2011). Application of plant-based genotoxicity assays is justifiable since the results attained using such systems generally correlate well with those obtained from analogous mammal-based tests (Celik & Aslanturk 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Application of plant-based genotoxicity assays is justifiable since the results attained using such systems generally correlate well with those obtained from analogous mammal-based tests (Celik & Aslanturk 2007). In this context, Lactuca sativa L. (lettuce) is widely used in the detection of mutagens and genotoxic compounds in extracts derived from medicinal plants because it exhibits elevated sensitivity to exogenous agents.…”

Section: Introductionmentioning

confidence: 99%

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Cytogenotoxic effects of ethanolic extracts of Annona crassiflora (Annonaceae)

et al. 2013

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Infusions of the leaves and seeds of Annona crassiflora Mart. are commonly employed in the treatment of diarrhoea, snakebites, tumours and disorders of the hair and scalp. The aim of the present study was to investigate the cytotoxic and genotoxic properties of ethanolic extracts of A. crassiflora by evaluating their effects on germination, root elongation, chromosome structure and the cell division of Lactuca sativa (lettuce). The experiment followed a randomized design involving the treatment of L. sativa seeds with ethanolic extracts from leaves and seeds of A. crassiflora applied at ten concentrations (0.0125, 0.025, 0.05, 0.1, 0.2, 0.4, 0.6, 0.8, 1.0, and 1.2 mg/L) and with five repetitions per treatment. Seeds of L. sativa exposed for 48 h to A. crassiflora leaf extract at concentrations ≥ 0.1 mg/L, or to seed extracts at concentrations ≥ 0.2 mg/L, showed germination percentages that were significantly (p < 0.05) lower than those of seeds exposed to aqueous ethanol control. Exposure of L. sativa seedlings to leaf (but not seed) extracts of A. crassiflora produced significant (p < 0.05) reductions in the mitotic indices of root meristem cells of lettuce and induced chromosome and nuclear abnormalities in the root cells. The presence of chromosome stickiness, bridges, fragments, laggard chromosomes and nuclear condensation were also observed. The cytogenetic effects observed suggest that folkloric medicines prepared with extracts of the leaves or seeds of A. crassiflora should be employed with caution.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytogenotoxic effects of ethanolic extracts of Annona crassiflora (Annonaceae)

et al. 2013

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“…Many herbal extracts have been reported to inhibit mitosis (Çelik & Aslantürk 2006;Çelik & Aslantürk 2007;Akinboro & Bakare, 2007). In the present study, methanolic extracts of D. anomala and the highest concentration of C. album decreased the MI in treated A. cepa roots.…”

Section: Examination Of the Results Of Tests With Camellia Sinensis Inmentioning

confidence: 52%

“…The benefits of vegetables and fruits not withstanding however, recent investigations have revealed that many plants used as food or in traditional medicine have mutagenic, cytotoxic and genotoxic effects in in vitro and in vivo assays (Higashimoto et al, 1993;Schimmer et al, 1994;Kassie et al, 1996;Çelik & Aslantürk, 2007). Medicinal herbs have also been shown to cause adverse effects or have the potential to interact with other medications (Zink & Chaffin, 1998).…”

Section: Introductionmentioning

confidence: 99%

Modulation of Mutagen-Induced Genotoxicity by two Lesotho Medicinal Plants in Allium cepa L

Asita¹,

Heisi²,

Tjale³

2015

ENRR

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Methanolic extracts (mg mL -1 ) of Dicoma anomala (0.0625, 0.125, 0.25), Chenopodium album (0.078, 0.156, 0.313), used in traditional medicine in Lesotho, and Camellia sinensis (0.1094, 0.2085, 0.44) were assessed for cytotoxicity, genotoxicity and modulation of Cyclophosphamide (CP 1.25 mg mL -1 ) -and EMS (0.25 mg mL -1 )-induced genotoxicity using the Allium cepa assay following 24 hours treatment. Cytotoxicity was measured by the mitotic index (MI). Genotoxicity (GT) was expressed as the number of aberrant mitotic cells per 100 mitotic cells. The MI and GT of test groups (triplicates), were compared with the negative (water) control group using t-test. Modulatory effect (ME) was calculated as, ME(%) = (1-(A-B)/(A-C) × 100) -1. A positive ME indicated an increase (synergism or potentiation) while a negative ME indicated a reduction (anti-genotoxicity) of mutagen-induced genotoxicity. The concentrations of D. anomala extract were cytotoxic and genotoxic. Mixtures of CP or EMS with the lower concentrations of D. anomala extract were more genotoxic than CP (250.50% increase) or EMS (149.74 and 157.37 % increase) or extracts alone. Only 0.313 mg mL -1 of C. album extract was cytotoxic but none of the three concentrations was genotoxic. Mixtures of CP with extracts of C.album were cytotoxic. CP-induced genotoxicity was reduced (55.18, 68.36, 57.40 %) and EMS-induced genotoxicity was also reduced by low concentrations (50.72, 61.13 %) of C.album extract. However, 0.313 mg mL -1 C. album extract increased (236.75%) EMS-induced genotoxicity. C. sinensis extracts and their mixtures with CP were not cytotoxic or genotoxic. CP-induced genotoxicity was reduced (63.61, 66.62, 78.64 %) but EMS-induced genotoxicity was increased (124.97, 4.48, 110.52 %) by C. sinensis extract.

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“…Many herbal extracts have been reported to inhibit mitosis and reduce the mitotic index (MI) (Çelik and Aslantürk, 2007;Akinboro and Bakare, 2007) which is attributed to the inhibition of DNA synthesis, blocking in the G2 phase of the cell cycle or inhibition of protein synthesis (Kim and Bendixen, 1987;Polit et al, 2003). The significance of the cytological and chromosomal aberrations such as chromosomal stickiness, chromosome fragments, lagging chromosomes, binucleated cells and micronuclei (MN) observed in these studies has been discussed by other authors (Patil and Bhat, 1992;Singh, 2003;Krishna and Hayashi, 2000;Çelik and Aslantürk, 2010).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Procavia capensis hyraceum used in traditional medicine for modulation of mutagen-induced genotoxicity

Asita¹,

Rantsâ€TMo²,

Magama³

et al. 2018

J. Med. Plants Res.

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Hyraceum (HM) is used in traditional medicine in Southern Africa. Three concentrations of HM (mg/ml in distilled water) (0.0156, 0.03125 and 0.0625) were assessed for cytotoxicity (CT), genotoxicity (GT) and modulation of cyclophosphamide (CP)-and ethyl methanesulfonate (EMS)-induced GT using the Allium cepa assay following 24 h treatment. CP (1.00 mg/ml) and EMS (0.0375 mg/ml) were not cytotoxic but genotoxic. HM (0.03125, 0.0625 mg/ml) and its mixtures with CP or EMS induced significant reduction (p <0.05) of the mitotic index (MI) and were adjudged cytotoxic. HM alone and its mixtures with CP or EMS induced statistically significant genotoxicity (p < 0.05). Mixture of HM (0.016 mg/ml) with CP was not significantly more genotoxic than CP alone (ME 0.57). Each mixture of HM (0.03125, 0.0625 mg/ml) with CP was insignificantly less genotoxic than CP alone with modulatory effect (ME) of -0.14 and -0.01, respectively, which suggested no interaction between HM and CP. Mixtures of HM with EMS induced positive and significant (>2-fold) MEs and each mixture was significantly (p < 0.05) more genotoxic than HM or EMS alone which indicated a synergistic interaction. Sticky chromosomes, chromosome laggards, chromosome fragments, anaphase and telophase bridges, binucleate interphase cells were observed.

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Cytotoxic and genotoxic effects of Lavandula stoechas aqueous extracts

Cited by 71 publications

References 27 publications

Cytogenotoxic effects of ethanolic extracts of Annona crassiflora (Annonaceae)

Cytogenotoxic effects of ethanolic extracts of Annona crassiflora (Annonaceae)

Modulation of Mutagen-Induced Genotoxicity by two Lesotho Medicinal Plants in Allium cepa L

Evaluation of Procavia capensis hyraceum used in traditional medicine for modulation of mutagen-induced genotoxicity

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