Cytotoxic and genotoxic effects of acitretin, alone or in combination with psoralen–ultraviolet A or narrow-band ultraviolet B-therapy in psoriatic patients

Silva, F S G; Oliveira, Hugo; Moreiras, A; Fernandes, João; Bronze-da-Rocha, Elsa; Figueiredo, Américo; Custódio, J.B.A.; Rocha‐Pereira, Petronila; Santos‐Silva, Alice

doi:10.1016/j.mrgentox.2012.12.017

Cited by 8 publications

(10 citation statements)

References 45 publications

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“…Psoriasis vulgaris is a common, chronic, proliferative, and recurrent inflammatory skin disease, with lesions that appear as a result of hyper proliferation, abnormal differentiation of keratinocytes, and epidermis infiltration with inflammatory cells including T cells and neutrophils. The etiology of psoriasis involves genetic, immune, and environmental factors [ 26 , 40 ]. To evaluate cytotoxic and genotoxic damage in psoriasis patients after treatment, Silva et al [ 26 ] performed a study in culture lymphocytes from psoriasis patients who received different treatment regimens: acitretin alone, acitretin + NBUVB (Narrow-band ultraviolet B irradiation), and acitretin + PUVA (psoralen + ultraviolet A irradiation).…”

Section: Resultsmentioning

confidence: 99%

“…The etiology of psoriasis involves genetic, immune, and environmental factors [ 26 , 40 ]. To evaluate cytotoxic and genotoxic damage in psoriasis patients after treatment, Silva et al [ 26 ] performed a study in culture lymphocytes from psoriasis patients who received different treatment regimens: acitretin alone, acitretin + NBUVB (Narrow-band ultraviolet B irradiation), and acitretin + PUVA (psoralen + ultraviolet A irradiation). Results showed that at T0 all patients and controls presented similar MN frequencies, at T12 (12 weeks after the administration of treatments), both “acitretin + NBUVB” and “acitretin + PUVA” showed a trend towards an increase in MN frequency; however, only “acitretin + PUVA” reached a significant higher MN frequency.…”

Section: Resultsmentioning

confidence: 99%

“…Results showed that at T0 all patients and controls presented similar MN frequencies, at T12 (12 weeks after the administration of treatments), both “acitretin + NBUVB” and “acitretin + PUVA” showed a trend towards an increase in MN frequency; however, only “acitretin + PUVA” reached a significant higher MN frequency. Authors state that the presence of psoriasis induced an increase in MN frequencies, and these frequencies were increased after 13 weeks of treatment with acitretin + PUVA [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

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Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review

Torres-Bugarı́n

Macriz-Romero

Ibarra

et al. 2015

BioMed Research International

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Autoimmune diseases (AD) are classified into organ-specific, systemic, and mixed; all forms of AD share a high risk for cancer development. In AD a destructive immune response induced by autoreactive lymphocytes is started and continues with the production of autoantibodies against different targets; furthermore apoptosis failure and loss of balance in oxidative stress as a consequence of local or systemic inflammation are common features seen in AD as well. Micronucleus (MN) assay can be performed in order to evaluate loss of genetic material in a clear, accurate, fast, simple, and minimally invasive test. The MN formation in the cytoplasm of cells that have undergone proliferation is a consequence of DNA fragmentation during mitosis and the appearance of small additional nuclei during interphase. The MN test, widely accepted for in vitro and in vivo genotoxicity research, provides a sensitive marker of genomic damage associated to diverse conditions. In here, we present a review of our work and other published papers concerning genotoxic effect in AD, identified by means of the MN assay, with the aim of proposing this tool as a possible early biomarker for genotoxic damage, which is a consequence of disease progression. Additionally this biomarker could be used for follow-up, to asses genome damage associated to therapies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review

Torres-Bugarı́n

Macriz-Romero

Ibarra

et al. 2015

BioMed Research International

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“…The beneficial effect of NB-UVB phototherapy may also be exerted through the modulation of the intracellular Ca 2+ homeostasis via cutaneous synthesis of the vitamin D. 9,10 Combination of systemic retinoids with NB-UVB reduces the time for lesions to clear and total radiation dose, improving overall safety, thereby increasing efficacy and reducing the carcinogenic potential of phototherapy. 11–13 There has been a case in which was reported a beneficial effect of Alitretinoin with NB-UVB in a patient with HHD. 14 Acitretin, a second-generation monoaromatic retinoid, is used in the treatment of severe keratinizing disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Acitretin reduces hyperproliferation, abnormal differentiation of keratinocytes, inflammatory infiltrate, and induces apoptosis of keratinocytes and lymphocytes. 12,15 Retinoids exert their physiologic effects by binding to receptors present in the nucleus: a retinoic acid receptor (RAR) family and a retinoid X receptor (RXR) family. 16 Acitretin activates but does not bind to multiple RAR receptors.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Hailey–Hailey disease with narrowband phototherapy and acitretin: A case report

Lapa¹,

Breslavets²

2019

SAGE Open Medical Case Reports

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The Hailey–Hailey disease, or familial benign chronic pemphigus, is an autosomal dominant genodermatosis affecting mainly intertriginous areas. It manifests itself in painful blisters, erosions, and cracks and has a chronic course with frequent flares, significantly impacting patients’ quality of life. Presently, there is no cure, but multiple treatment modalities are available. Most evidence supports treatment with topical steroids and antimicrobials. Treatment of recalcitrant disease has been shown to benefit from the addition of oral antibiotics, Naltrexone, systemic retinoids, botulinum toxin A injections, laser treatment, and surgical excision. We describe a case of refractory Hailey–Hailey disease for which most of the abovementioned options failed, but which demonstrated significant improvement following a combination of oral acitretin and narrowband ultraviolet-B phototherapy. To achieve remission, the patient received 30 sessions three times per week with the increment of 20 mJ/cm 2 per session and oral acitretin 25 mg PO daily.

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Genotoxic effect of simultaneous therapeutic exposure to polycyclic aromatic hydrocarbons and UV radiation

Málková

Borská

Šmejkalová

et al. 2020

J of Applied Toxicology

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Polycyclic aromatic hydrocarbons (PAHs) and ultraviolet radiation (UV) represent genotoxic factors that commonly occur in the living and working environment. The dermal form of exposure represents a significant part of the total load of dangerous chemical and physical environmental factors to which an organism is subjected. However, simultaneous dermal exposures to PAHs (pharmaceutical crude coal tar [CCT]) and UV (UVA and UVB) also have therapeutic uses. A typical example is Goeckerman therapy (GT) for psoriasis. The question of the therapeutic efficacy of GT and the related level of genotoxic danger is still under discussion. The aim of the present study was to compare four GT variants (G1–G4) in terms of efficacy and acceptable genotoxic hazard. Efficacy was expressed by the psoriasis area of severity index (PASI) score, genotoxic hazard by chromosomal aberration in peripheral lymphocytes. The lowest risk of genotoxic hazard and the lowest efficiency was observed in G1 variant (3% of the CCT and UVA + UVB). The efficacy of G2 (4% CCT and UVA + UVB), G3 (4% CCT and UVB), and G4 variants (5% CCT and UVA + UVB) was comparable. The highest risk of genotoxic hazard was found in the G3 variant. In the terms of sufficient efficacy and acceptable genotoxic hazard, a combination of 4% or 5% of CCT and UVA and UVB seems to be acceptable (variants G2 and G4).

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Cytotoxic and genotoxic effects of acitretin, alone or in combination with psoralen–ultraviolet A or narrow-band ultraviolet B-therapy in psoriatic patients

Cited by 8 publications

References 45 publications

Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review

Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review

Treatment of Hailey–Hailey disease with narrowband phototherapy and acitretin: A case report

Genotoxic effect of simultaneous therapeutic exposure to polycyclic aromatic hydrocarbons and UV radiation

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