Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17

Fang, Wei; Lin, Xiuping; Zhou, Xuefeng; Wan, Junting; Lu, Xin; Yang, Bin; Ai, Wen; Lin, Ji; Zhang, Tianyu; Tu, Zhengchao; Liu, Yonghong

doi:10.1039/c3md00371j

Cited by 76 publications

(87 citation statements)

References 9 publications

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“…The cytotoxic activities against ten human tumor cell lines, K562, A549, HL60, Huh-7, MCF-7, H1975, U937, BGC-823, Hela, and Molt-4, were determined according to previously reported methods [17]. Antibacterial and antifungal assay against Escherichia coli (ATCC 29922 ) , Klebsiella pneumonia (ATCC 13883), Staphylococcus aureus (ATCC 29213), Enterococcus faecalis (ATCC 29212), Acinetobacter baumannii (ATCC 19606), Aeromonas hydrophila (ATCC 7966) and pathogens Fusarium sp., Penicillium sp., Aspergillus niger , Rhizoctonia solani , Fusariumoxy sporium f. sp.…”

Section: Methodsmentioning

confidence: 99%

New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240

et al. 2014

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Four new prenylxanthones, emerixanthones A–D (1–4), together with six known analogues (5–10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determined by NMR (1H, 13C NMR, HSQC, HMBC, and 1H-1H COSY), MS, CD, and optical rotation analysis. The absolute configuration of prenylxanthone skeleton was also confirmed by the X-ray crystallographic analysis. Compounds 1 and 3 showed weak antibacterial activities, and 4 displayed mild antifungal activities against agricultural pathogens.

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Section: Methodsmentioning

confidence: 99%

New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240

et al. 2014

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“…Moreover, its toxicity to HCC2998, colon cancer HCT116, and central nervous system (CNS) cancer SNB-75 cells is comparable to that of etoposide (Belofsky et al 1998). Against human H1975 (lung cancer), U 9 3 7 ( l e u k e m i c m o n o c y t e l y m p h o m a ) , K 5 6 2 (erythroleukemia), BGC-823 (grastic cancer), Molt-4 (acute lymphoblastic leukemia), MCF-7, A549 (lung cancer), Hela, HL60 (promyelocytic leukemia), and Huh-7 (hepatocarcinoma) cells, 167 exhibited the similar activity to 163, which suggests the position of the p-nitrobenzoyl group to be irrelevant to their cytotoxicity (Fang et al 2014). Additionally, 167 also showed antiviral ability against human enterovirus 71 (EV71) with an IC 50 value of 9.4 μM (Fang et al 2014).…”

Section: Terpenoidsmentioning

confidence: 80%

Mycochemistry of marine algicolous fungi

Wang

2016

Fungal Diversity

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Marine algicolous fungi refer to the fungi inhabiting or associated with marine algae, which have attracted a great attention for natural product researchers due to their chemical diversity and biological activity during the past two decades. Up to the end of 2014, a total of 366 new natural products, including polyketides, terpenoids, polyketide-terpenoids, peptides, alkaloids, and shikimate derivatives, have been characterized from them. Among these metabolites, 240 compounds feature cytotoxic, antibacterial, antifungal, antimicroalgal, zooplankton-toxic, antiprotozoal, antioxidative, enzyme-modulatory, and/or some other activities. This review gives a comprehensive coverage of both chemical and biological aspects of the secondary metabolites from marine algicolous fungi.

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“…Gallic acid (GA, 28) isolated from Woodfordia fruticosa Kurz (family; Lythaceae) flowers exhibited a higher anti-EV71 activity than the extract of W. fruticosa flowers, with an IC50 of 0.76 µg/mL and no cytotoxicity at a concentration of 100 µg/mL [23]. Polydatin (29) and resveratrol (30) were major active components in Polygonum cuspidatum, and have antioxidant, anti-inflammatory and antitumor functions. Resveratrol (30) revealed strong antiviral activity on EV71, while polydatin (29) had weak effect.…”

Section: Polyphenolsmentioning

confidence: 99%

“…Resveratrol (30) was nonpoisonous to Vero cells with an median toxic concentration (TC50) of 307.6 µM. Resveratrol (30) has an obvious inhibitory effect against EV 71 only before the cell infection by the virus (IC50 = 20.2 µM) [25]. Aurintricarboxylic acid (ATA, 31) was found to be a potent inhibitor of EV71 replication with an EC50 of 2.9 μM.…”

Section: Polyphenolsmentioning

confidence: 99%