2015
DOI: 10.3390/molecules200916320
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Anti-Enterovirus 71 Agents of Natural Products

Abstract: This review, with 42 references, presents the fascinating area of anti-enterovirus 71 natural products over the last three decades for the first time. It covers literature published from 2005-2015 and refers to compounds isolated from biogenic sources. In total, 58 naturally-occurring anti-EV71 compounds are recorded.

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Cited by 16 publications
(13 citation statements)
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References 39 publications
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“…EV71 is the primary causative agent for HFMD outbreaks in Asian countries ( Liu et al, 2011 ; Wang et al, 2012 ). Unfortunately, currently available antiviral drugs have limited efficacy against EV71 infection, though inhibitors targeting various phases of the EV71 lifecycle ( Wang L. et al, 2015 ) are currently at the preclinical stage. Therefore, we reasoned that an advanced understanding of the pathogenic mechanism of EV71 virus may help to provide a basis for the design of effective drugs to treat HFMD.…”
Section: Discussionmentioning
confidence: 99%
“…EV71 is the primary causative agent for HFMD outbreaks in Asian countries ( Liu et al, 2011 ; Wang et al, 2012 ). Unfortunately, currently available antiviral drugs have limited efficacy against EV71 infection, though inhibitors targeting various phases of the EV71 lifecycle ( Wang L. et al, 2015 ) are currently at the preclinical stage. Therefore, we reasoned that an advanced understanding of the pathogenic mechanism of EV71 virus may help to provide a basis for the design of effective drugs to treat HFMD.…”
Section: Discussionmentioning
confidence: 99%
“…Arrays of biologically active compounds found in plants have been shown to be effective against diverse viruses. For instance, raoulic acid, ursolic acid, matrine, chrysosplenetin, and penduletin have all been shown to inhibit EV-A71 replication in vitro [6]. In addition, a group of polyphenolic compounds from plants known as flavonoids have been shown to exhibit antiviral properties against various viruses [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…Many natural products and their synthetic analogs and derivatives have exhibited interesting inhibitory activity. 190 Bioactivity of some secondary metabolites from fungal sources against EV71 has been described here.…”
Section: Fungal Metabolite Inhibitors For Various Viral Diseasesmentioning
confidence: 99%
“…xanthones and terpenoid derivatives were isolated from the cultures of sponge-derived fungus Stachybotry sp. 191 Compounds [189], [190], and [191] displayed activities against intestinal virus EV71 with IC 50 values of 30.1, 50.0, and 40.3 mM, respectively. Compounds [188], [189], and [191] also exhibited significant inhibitory activity against cycloooxygenase (COX-2) with IC 50 values of 10.6, 8.9, and 34.3 mM, respectively.…”
Section: Inhibitors For Herpes Virusesmentioning
confidence: 99%