Cytotoxic and antiproliferative effects of thymoquinone on rat C6 glioma cells depend on oxidative stress

Крылова, Н. Г.; Drobysh, Maryia; Семенкова, Г. Н.; Kulahava, Tatsiana; Pinchuk, S. V.; Шадыро, О. И.

doi:10.1007/s11010-019-03622-8

Cited by 19 publications

(15 citation statements)

References 64 publications

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“…TQ can also undergo a non-enzymatic reduction through its interaction with glutathione (GSH) forming glutathionyl-dihydrothymoquinone with antoxidant activity. oxidoreductase can generate thymohydroquinone with potent anti-oxidant activity [25][26][27][28]. TQ can also undergo a non-enzymatic reduction through its interactions with glutathione forming glutathionyl-dihydrothymoquinone in physiological conditions [29].…”

Section: Redox Cycling and Anticancer Activity Of Tqmentioning

confidence: 99%

“…As opposed to the one-step one electron reduction that generates the pro-oxidative derivatives of TQ, a two electron reduction of TQ by NADPH quinone oxidoreductase or further reduction of semiquinone by NADPH cytochrome p450 reductases, cytochrome b5 reductase, and NADPH ubiquinone oxidoreductase can generate thymohydroquinone with potent anti-oxidant activity [ 25 - 28 ]. TQ can also undergo a non-enzymatic reduction through its interactions with glutathione forming glutathionyl-dihydrothymoquinone in physiological conditions [ 29 ].…”

Section: Redox Cycling and Anticancer Activity Of Tqmentioning

confidence: 99%

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Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

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Section: Redox Cycling and Anticancer Activity Of Tqmentioning

confidence: 99%

Section: Redox Cycling and Anticancer Activity Of Tqmentioning

confidence: 99%

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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“…There is limited information on the etiology of glioblastomas. Most common factors in the etiology of glioblastomas are environmental factors such as radiation and environmental toxins and oxidative stress (Krylova et al 2019;Xiao et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Clostridium botulinum neurotoxin A inhibits DBTRG glioblastoma cell proliferation and TRPV1 channel signaling pathways

Akyuva¹

2020

Journal of Cellular Neuroscience and Oxidative Stress

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Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease. Areas of particular interest are four topics. They are; A-Ion Channels (Na +-K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)

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“…ese results suggested potential applications of TQ for HCC treatment in clinical practices [67][68][69][70][71]. TQ was a perspective chemotherapeutic drug on gliomas and glioblastomas as it could cross the blood-brain barrier with selective virulence for glioblastoma cells in comparison with primary astrocytes [72]. Another study also showed that the eukaryotic elongation factor-2 kinase (eEF-2K) was highly expressed in triple-negative breast cancer cells, promoting cell proliferation, migration, and invasion.…”

Section: Anticancer Activitymentioning

confidence: 95%

Recent Progress on Chemical Constituents and Pharmacological Effects of the Genus Nigella

Niu

Zhou

Meng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Seeds of the genus Nigella plants as folk medicine are often used to prevent and treat asthma, diarrhea, dyslipidemia, and other diseases around the world. Pharmacological researches showed that seed extract and seed oil have antibacterial, antioxidant, hypoglycemic, and hepatoprotective effects which attributed to their bioactive constituents such as alkaloids, saponins, flavones, and phenols. This paper has covered recent progresses on chemical and pharmacological researches on these plants, including their compounds and pharmacological effects. It was found that the chemical component researches were focused on the seed oil. Therefore, more attention should be paid to the profile of the whole constituents in the seeds.

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Cytotoxic and antiproliferative effects of thymoquinone on rat C6 glioma cells depend on oxidative stress

Cited by 19 publications

References 64 publications

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Clostridium botulinum neurotoxin A inhibits DBTRG glioblastoma cell proliferation and TRPV1 channel signaling pathways

Recent Progress on Chemical Constituents and Pharmacological Effects of the Genus Nigella

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