Recent Progress on Chemical Constituents and Pharmacological Effects of the Genus <i>Nigella</i>

Niu, Yun; Zhou, Li; Meng, Lijun; Chen, Sitan; Ma, Changyang; Liu, Zhenhua

doi:10.1155/2020/6756835

Cited by 15 publications

(16 citation statements)

References 79 publications

(53 reference statements)

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“…Yun et al studied chemical constituents and pharmacological effects of the genus Nigella sativa. The urinary and tissue parameters results showed that calcium crystals formation and oxalate excretion were significantly reduced, indicating a therapeutic and prophylactic effect of these seeds on kidney stones (19). In our study, the drug's clinical efficacy in improving pain and excretion of kidney and ureteral stones was investigated.…”

Section: Discussionmentioning

confidence: 84%

Comparison efficacy of oral Nigella sativa seeds and tamsulosin on pain relief and passage of 4 to 10 mm stones of kidney and ureter; a randomized clinical trial

2021

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Introduction: Urinary stones are the third most common urinary tract disease after urinary tract infections and prostate diseases. Objectives: The aim of this study was to compare efficacy of Nigella sativa seeds and tamsulosin on expulsion and pain relief of ureteral and renal stones smaller than 10 mm. Patients and Methods: In this randomized clinical trial study conducted from March 2018-2019, 80 patients over 18 years old with kidney and ureteral stones sized between 4 to 10 mm were assigned to two groups by the simple random sampling method. In group one, after performing ultrasonography and confirming the presence of 4 to 10 mm stones, one 0.4 mg capsule of tamsulosin was prescribed each night for two weeks. In group 2, one gram of Nigellasativa prescribed every 12 hours after each meal with a glass of water for two weeks. After 2 weeks, patients were visited while a urinary tract sonography was conducted and the modification in size of stones and the existence of residual stones were measured and noted. The pain severity was measured through the visual analog scale (VSA). Data was gathered and analyzed throughout treatment and at the end of the study by the SPSS version 21 software, chi-square and independent t tests. Results: Mean sizes of stones before treatment with Nigella versus tamsulosin groups were 10.3±1.81 and 9.41 ± 1.68 mm respectively (P=0.06). Mean size of stones after treatment with Nigella versus tamsulosin groups were 4.97±4.33 and 5.21 ± 3.63 mm respectively (P=0.39). There was no significant difference between two groups regarding average of the pain score after treatment (P=0.05), but after intervention this score significantly declined in both groups, indicating more substantial in Nigella sativa group (P=0.001). Efficacy of treatment in Nigella and tamsulosin groups was 78.5 and 61.6, respectively (P=0.005). Conclusion: The present study indicated that both Nigella sativa seed and tamsulosin reduce urinary stone size and numbers without significant difference, however stone passage and pain control was more in the group of Nigella sativa. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trial (identifier: IRCT20081011001323N23; https://irct.ir/user/trial/35993/, ethical code; IR.YUMS.REC.1397.155).

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Section: Discussionmentioning

confidence: 84%

Comparison efficacy of oral Nigella sativa seeds and tamsulosin on pain relief and passage of 4 to 10 mm stones of kidney and ureter; a randomized clinical trial

2021

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“…According to literature, 22,23 the K-B method was used to determine antibacterial activity. The half inhibitory concentration (IC 50 ) was determined by liquid culture method.…”

Section: Methodsmentioning

confidence: 99%

Antibacterial Mechanism of Dihydrotanshinone I

Zhao

Wei

et al. 2021

Natural Product Communications

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The antimicrobial activity and the underlying action mechanisms of dihydrotanshinone I against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, extended-spectrum beta-lactamases Staphylococcus aureus were investigated with Kleihauer-Betke (K-B) test. The antibacterial mechanisms of dihydrotanshinone I were investigated by monitoring the changes in electric conductivity, concentration of AKP, protein content, and patterns of protein electrophoretic bands in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The antibacterial rings showed that antimicrobial activity of dihydrotanshinone I at 18 mM was stronger to Staphylococcus aureus than to methicillin-resistant Staphylococcus aureus and extended-spectrum beta-lactamases Staphylococcus aureus. The minimum inhibitory concentration (MIC) and IC50 values showed that dihydrotanshinone I had the strongest inhibitory activity against S. aureus (MIC = 280 µM, IC50 = 874 ± 0.01 µM, respectively). Dihydrotanshinone I could increase the electric conductivity, concentration of alkaline phosphatase (AKP) and protein content. The patterns of protein bands in SDS-PAGE were changed obviously. Dihydrotanshinone I also significantly inhibited S. aureus, methicillin-resistant S. aureus, and extended-spectrum beta-lactamases S. aureus, indicating that dihydrotanshinone I can damage the structures of cell wall and cell membrane to increase permeability of cell membrane and release of cell components. Dihydrotanshinone I could influence the synthesis of bacterial protein, destroy the protein, or reject the anabolism or expression of the protein, and finally lead to the loss of normal physiological function of bacteria.

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“…Nigella sativa, belonging to the family Ranunculaceae, is distributed in southwest Asia, North Africa, and Southern Europe (16). N. sativa seeds are exhibited in time-honored traditions through their usage as wind dispelling agents, diuretics, insect repellents, and dietary supplements (17)(18)(19). The seeds of N. sativa have been shown to exert anticancer, immunomodulative, anti-inflammatory, anti-bacterial, antioxidant, hypoglycemic, stomach protection, liver protection, and renal protection activities (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa: A Dietary Supplement as an Immune-Modulator on the Basis of Bioactive Components

et al. 2021

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Nutrients can be considered as functional foods, which exert physiological benefits on immune system. The seeds of Nigella sativa, which have many active constituents, are mainly used for medicine, food spice, and nutritional supplements in Egypt. Much attention has been paid to N. sativa seeds for their anticancer, antibacterial, anti-inflammatory, and immune properties. However, their active constituents and mechanisms underlying functions from N. sativa seeds is unclear. Thus, the bioactive constituents with immune regulation in N. sativa seeds were systematically studied. A new compound (3-methoxythymol-6-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside 1) and 11 known compounds (2–12) were separated from the N. sativa seeds by chromatographic methods. Their structures were then elucidated by spectroscopic analysis of MS, UV, IR, 1H-, and 13C-NMR. Furthermore, immunomodulatory effects of those compounds in RAW 264.7 cells were evaluated by phagocytosis, nitric oxide (NO) and cytokine release, related mRNA transcription, and key proteins expression in vitro. Monosaccharide derivatives, Ethyl-α-D-furaarabinose (5), and Ethyl-β-D-fructofuranoside (8) were shown to played bidirectional regulatory roles in immunity and anti-inflammation through the regulation of nuclear factor-κB (NF-κB) signaling pathways. The results showed the active compounds and mechanisms of immune regulation in N. sativa, thus indicating that N. sativa seeds could be used as dietary supplements in immunomodulation.

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Recent Progress on Chemical Constituents and Pharmacological Effects of the Genus Nigella

Cited by 15 publications

References 79 publications

Comparison efficacy of oral Nigella sativa seeds and tamsulosin on pain relief and passage of 4 to 10 mm stones of kidney and ureter; a randomized clinical trial

Comparison efficacy of oral Nigella sativa seeds and tamsulosin on pain relief and passage of 4 to 10 mm stones of kidney and ureter; a randomized clinical trial

Antibacterial Mechanism of Dihydrotanshinone I

Nigella sativa: A Dietary Supplement as an Immune-Modulator on the Basis of Bioactive Components

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