Cytotoxic and antiparasitic activities of diphosphine-metal complexes of group 10 containing acylthiourea as ligands

Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review

“…13). 79 Al-Salim and Al-Asadi synthesized acyl thiourea derivatives and their Cu(II) complexes (126a-e), molecular docking studies and the activity of synthesized compounds as anticancer agents against breast cancer was reported (Fig. 55).…”

“…In one complex intramolecular p stacking sandwich interaction between two phenyl groups was observed while the other lacked this type of interaction. 79 Tudor et al synthesized a series of Cu(I) complexes with acyl thiourea and phosphine ligands by adding N-benzoyl thiourea ligands (66 or 67) to the solution of precursors [CuCl(PPh 3 ) 4 ] or [CuBr(PPh 3 ) 3 ] in toluene (Fig. 14).…”

“…13). 79 6.1.6 Analgesic activity. Novel 1-allyl-3-(4-tertiarybutylbenzoyl)thiourea (116) was synthesized and investigated for analgesic activity by Razak et al The synthesized compound showed better interaction with pain receptors and was found more potent analgesic agent than Diclofenac sodium.…”

“…In one complex intramolecular π stacking sandwich interaction between two phenyl groups was observed while the other lacked this type of interaction. 79 …”

Synthesis and biological evaluation of ruthenium complexes bearing the 1,2,4-triazole group as potential membrane-targeting antibacterial agents towards Staphylococcus aureus

“…Since 1978, when the U.S. FDA approved cisplatin as the first platinum complex anti-cancer drug, 14 metal complexes have been explored in a number of fields, and some of them with excellent biological activity have been used in clinical therapeutics. 15,16 Metal complexes show a wide range of pharmacological properties, such as antiparasitic, 17 anti-Alzheimer's disease, 18 anti-diabetic, 19 anti-inflammatory 20 and antitubercular activity. 21 Besides cisplatin, other transition metal complexes have also attracted much attention, especially ruthenium metal complexes with their special chemical properties and pronounced antibacterial activity and low cytotoxicity.…”