Cytotoxic and antioxidative activities of Plantago lagopus L. and characterization of its bioactive compounds

Harput, Ü. Şebnem; Genç, Yasin; Saraçoğlu, İclal

doi:10.1016/j.fct.2012.01.019

Cited by 74 publications

(70 citation statements)

References 33 publications

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“…Forsythoside B (125), leucosceptoside B (126) and 121 were isolated from Verbascum xanthophoeniceum and exhibited potent antioxidant activities in 2, 2 1 -diphenyl-1-picrylhydrazyl (DPPH), oxygen radical absorbance capacity (ORAC FL ), hydroxyl radical averting capacity (HORAC FL ), ferric-reducing antioxidant power (FRAP) and superoxide anion radical scavenging assays [1]. In another study, Harput et al reported calceorioside A (127) as well as 121 showed strong radical scavenging effects against DPPH, NO and superoxide anion radical comparable to that of known antioxidants [74]. Recently, DPPH¨scavenging, anti-LP assays, ABTS +¨s cavenging, OH scavenging, superoxide anion radical scavenging, Cu 2+ -chelating and FRAP assays were used to evaluate the antioxidant activities of poliumoside (128), alyssonoside (129), brandioside (130), 121, 125 and their derivatives, and the tested compounds were all screened out as antioxidants [75].…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…It inhibited phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 expression via Ca 2+ -dependent calmodulin-dependent protein kinase (CaMK)/ERK and JNK/nuclear factor-κB (NF-κB)-signaling pathways [94]. Cytotoxic activities of 121 and 127 against human larynx epidermoid carcinoma, human rhabdomyosarcoma and human MCF-7 cell lines were determined with the IC 50 from 36.24 µg/mL to 64.6 µg/mL, and apoptotic cell death was observed in histological analysis [74]. In another study, compounds 119, 120, 121, 125, 129, and decaffeoyl-acteoside (134) from Marrubium thessalum were assayed by MTT and 3 H-thymidine incorporation assays, and 120 and 121 showed tumor toxicity, while, they also showed low toxicity against peripheral blood mononuclear cells [95].…”

Section: Anti-tumor Activitymentioning

confidence: 99%

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Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

2016

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Phenylethanoid glycosides (PhGs) are widely distributed in traditional Chinese medicines as well as in other medicinal plants, and they were characterized by a phenethyl alcohol (C 6 -C 2 ) moiety attached to a β-glucopyranose/β-allopyranose via a glycosidic bond. The outstanding activity of PhGs in diverse diseases proves their importance in medicinal chemistry research. This review summarizes new findings on PhGs over the past 10 years, concerning the new structures, their bioactivities, including neuroprotective, anti-inflammatory, antioxidant, antibacterial and antivirus, cytotoxic, immunomodulatory, and enzyme inhibitory effects, and pharmacokinetic properties.

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Section: Antioxidant Activitymentioning

confidence: 99%

Section: Anti-tumor Activitymentioning

confidence: 99%

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

2016

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“…The highly diverse genus Plantago has been used as traditional medicinal plant for centuries. It was reported to have biological activities including antiinflammatory, analgesic, anti-tumoral, anti-spasmodic, hepatoprotective, antiviral, antibacterial, antifungal and antiulcerogenic [12,13]. The aim of the present study was to evaluate the allelopathic potential of Plantago lagopus, Plantago major and Plantago squarrosa extracts on the germination and early seedling growth of the noxious weed B. pilosa.…”

Section: Introductionmentioning

confidence: 99%

Phytotoxicity of three Plantago species on germination and seedling growth of hairy beggarticks (Bidens pilosa L.)

El-Gawad

Mashaly²,

Ziada³

et al. 2015

Egyptian Journal of Basic and Applied Sciences

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Available online A B S T R A C TPlantago genus has a wide geographical distribution all over the world. It has been widely used in folk medicine for various purposes, where it is used as anti-inflammatory, antimicrobial and antitumor agent. In this research, total phenols, tannins, saponins, flavonoids and alkaloids were determined in Plantago lagopus, Plantago major and Plantago squarrosa.Furthermore, concentrations of 2.5, 5, 7.5 and 10 mg ml −1 of both alcoholic and aqueous extracts were prepared to study their phytotoxic effect on the germination and seedling growth of the noxious weed Bidens pilosa. P. major expressed the highest values of total phenolics, tannins and flavonoids. However, P. lagopus has the highest content of alkaloids. The germination of B. pilosa was completely inhibited under treatment of P. lagopus and P. major methanolic extracts at 7.5 mg ml −1 and 10 mg ml −1 , respectively. However, the allelopathic effect of P. lagopus aqueous extract showed a complete inhibition of B. pilosa germination followed by P. major. The germination inhibition of B. pilosa increased with the increase in the extracts concentration. In addition, both radicle and plumule were strongly inhibited under the same treatment. Our results showed a potent allelopathic effect on B. pilosa that could be valorized in managing this noxious weed as an ecofriendly bio-control method.However, other studies are needed for the identification, characterization of the responsible allelochemicals and for the demonstration of their modes of action. Production and hosting by Elsevier B.V. on behalf of Mansoura University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).

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“…The cells viability was defined as ratio (expressed as percentage) of total number of viable cells to total number of cells. 10,11 …”

Section: Cytotoxic Activitymentioning

confidence: 99%

Immunosuppressive effect of extracts from leaves of Fraxinus Mandshurica Rupr.

Chen

Xue

Liu³

et al. 2016

Bioengineered

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Plants provide a rich resource of medicinal material for research and development of new medicine. To discover new compounds as Immunosuppressant from plants, we evaluated the immunosuppressive effect of different fractions and particularly one compound (Calceolarioside A) that were extracted from the leaves of Fraxinus Mandshurica Rupr. The fractions and the compound were tested on the ability to reduce Immunoglobulin E (IgE) secretion by human U266 multiple myeloma cells (U266 cells) and to reduce interleukin-2 (IL-2) secretion by mouse spleen cells. Our results showed that both the butanol extract fraction and the compound of Calceolarioside A inhibited the IgE and IL-2 production in U266 cells and mouse spleen cells respectively, and no cytotoxicity was observed within the effective dose range. These results suggest that Calceolarioside A could potentially serve as an immunosuppressant.

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Cytotoxic and antioxidative activities of Plantago lagopus L. and characterization of its bioactive compounds

Cited by 74 publications

References 33 publications

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

Phytotoxicity of three Plantago species on germination and seedling growth of hairy beggarticks (Bidens pilosa L.)

Immunosuppressive effect of extracts from leaves of Fraxinus Mandshurica Rupr.

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