Cytotoxic and Antioxidant Compoundsfrom the Stem Bark of Goniothalamus tapisoides Mat Salleh

Abstract

Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM.

Apoptosis Induction in Human Leukemic Promyelocytic HL-60 and Monocytic U937 Cell Lines by Goniothalamin

“…GTN can also be extracted from several other species of Goniothalamus such as Goniothalamus macrophyllus (Alabsi et al, 2012), Goniothalamus tapisoides Mat Salleh (Kim et al, 2012) and Goniothalamus andersonii (Inayat-Hussain et al, 1999).…”

Brefeldin A Effectively Inhibits Cancer Stem Cell-Like Properties and MMP-9 Activity in Human Colorectal Cancer Colo 205 Cells

“…The long-term costs of colorectal cancer, estimated up to be $50,175 per patient in 2009, continue to rise [2]. Colorectal cancer rates have increased rapidly in countries including Taiwan [3], and effective therapeutic solutions are urgently needed [4].…”

A 2H-tetrahydropyran derivative and bioactive constituents from the bark of Goniothalamus elegants Ast

“…Phytochemical studies on Goniothalamus species have led to the identification of a variety of compounds: styryllactones, acetogenins, phenanthrene lactams, naphthoquinones, azaanthraquinones, terpenoids, flavonoids and steroids [3][4][5][6][7][8][9][10]. Several styryllactones have had their cytotoxic activity against human cancer cell lines reported in the literature [11][12][13][14]. This study was initiated by the results of a medicinal plant survey in Phu Dong Ee-Pia Forest, Ubonratana District, Khon Kaen Province, Thailand.…”

“…A preliminary biological screen revealed that the crude EtOAc and MeOH extracts from the bark of G. elegants showed cytotoxic activity against the KB oral cavity cancer cell line with % inhibition of 98.09 and 69.12, respectively. In the present work, we report the bioactive constituents, a new 6-epi-goniothalesdiol A (1), nine known styryllactones (2-10) and five known aristolactams (11)(12)(13)(14)(15) isolated from the EtOAc and MeOH extracts of the bark of G. elegants. The isolation and structure elucidation as well as bioactivity evaluation of the isolated compounds are discussed.…”

“…In addition, compounds 2, 4, 10, and 14 showed potent cytotoxicity against the NCI-H187 cell line with IC 50 values of 2.17, 1.44, 0.538 and 0.072 µg/ml, respectively. Among the fifteen compounds, it is very interesting to note that aristolactam 14 showed not only non cytotoxicity to normal cell, but also exhibited significant cytotoxicity against the small cell lung cancer with an IC 50 value of 0.072 µg/ml, that was stronger than the standard drug, ellipticine (IC 50 = 1.12 µg/ml).In summary, a new 6-epi-goniothalesdiol A (1), along with nine styryllactones (2-10) and five aristolactams(11)(12)(13)(14)(15) were isolated from the bark of G. elegants. Biological activities of the isolated compounds were evaluated and it was found that most of them exhibited cytotoxicity against one or more cancer cell lines including KB, MFC7 and NCI-H187 cells.…”