Cytotoxic and Antimicrobial Compounds from Cinnamomum cebuense Kosterm. (Lauraceae)

Espineli, Dinah L.; Agoo, Esperanza Maribel G.; Fierro, Ramon S. del; Shen, Chien‐Chang; Ragasa, Consolacion Y.

doi:10.1007/s11094-014-1157-9

Cited by 5 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Reynertson et al (2005) discovered that preparing traditional cinnamon tea could degrade and get rid of safrole. Espineli et al (2014) evaluated the cytotoxic nature of various compounds of C. cebuense. Cytotoxic compounds against colon carcinoma and non-cancer Chinese hamster ovary cells were: humulene, 4-hydroxy-3-methoxycinnamaldehyde, and monoterpene.…”

Section: Local Medicinal Usesmentioning

confidence: 99%

“…Alimpoos et al (2018) report C. cebuense as a potential anti-proliferative agent of cancer cells. Other constituents of C. cebuense were also found to have antimicrobial activity against bacteria such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis, and fungi such as Candida albicans and Trichophyton mentagrophytes (Espineli et al 2014). The inhibition activity of α-terpineol against B. subtilis remarkably surpassed that of the standard antibiotic chloramphenicol.…”

Section: Local Medicinal Usesmentioning

confidence: 99%

See 1 more Smart Citation

Cinnamomum cebuense Kosterm Lauraceae

Dapar¹

2020

Ethnobotany of Mountain Regions

View full text Add to dashboard Cite

Botany and Ecology Medium-sized tree, ca. 6-8 m. Bark, root, and crushed leaves aromatic with a characteristic smell of cloves (eugenol), sassafras (safrole), or a combination of these odors (Figs. 1 and 2). Twigs terete, ca. 1-5 mm diameter glabrous. Branchlets and bark smooth; terminal buds small, glabrous, not perulate. Leaves opposite, leathery, smooth, pale green, elliptic to ovate, ca. 16 cm long and 11 cm wide; base obtuse; apex acuminate; lateral veins ascend toward the leaf tip, intercostal veins scalariform; mature blades glabrous; margin entire. Inflorescences axillary (Fig. 3); panicles ca. 17 mm long, puberulous; paniculate cymose, branching, flowers of the ultimate branch arranged in cyme; rachis angular; bracts persistent. Flowers bisexual, trimerous, appressed hairy, receptacle tube shallow. Petals smooth and scarcely exerted. Fruit smooth, narrowly ellipsoid to obovoid ca. 2 cm long, ovoid to globose seated on cupule, drupaceous, epicarp waxy, glabrous, pericarp thin or thick, often fragrant. Seeds 1 per fruit, smooth, glabrous; endosperm absent; germination hypogeal (Fig. 4). Etymologically, this species was named for its type locality (Sitio Cantipla, Barangay Tabunan, Cebu City), where it was collected as described by Kostermans in 1986. Cinnamomum cebuense is one of 21 Cinnamomum species with complex

show abstract

Section: Local Medicinal Usesmentioning

confidence: 99%

Section: Local Medicinal Usesmentioning

confidence: 99%

Cinnamomum cebuense Kosterm Lauraceae

Dapar¹

2020

Ethnobotany of Mountain Regions

View full text Add to dashboard Cite

show abstract

“…Aside from being a good source of essential oils and timber (Ravindran et al, 2004), it is also used as a remedy for gastric pains (Del Fierro et al, 2012), an antispasmodic (Jaafarpour et al, 2015), aromatic, astringent, antiseptic, germicidal, and a remedy for flatulence (Vijayan and Thampuran, 2004). There are 21 species of cinnamon that can be found in the Philippines, 16 of which are known to be endemic (Ragasa et al, 2014). C. cebuense Kosterm.is one of those endemic cinnamon trees that can only be found in Cebu Island, Philippines and it is commonly called as kaningag or kalingang.…”

Section: Introductionmentioning

confidence: 99%

Antiangiogenic and morphological effects of Cinnamomum cebuense Kosterm. leaf extracts on Anas platyrynchos L. embryonic development usingan in vivo chorioallantoic membrane (CAM) assay

2018

Int. J. Biosci.

View full text Add to dashboard Cite

The theoretical efficacy of antiangiogenic treatment in tumor growth and other angiogenesis-dependent diseases offers a promising approach that leads to the robust search of angiogenesis inhibitors. Cinnamon species, widely used in food processing and other commercial industries, are among the medicinal plants currently being exploited by many cancer researches that involve inhibition of angiogenesis. The Cebu endemic Cinnamomum cebuense is popular for its bark as a remedy for stomachache, headache and toothaches. Phytochemicals found in many cinnamon species worldwide that were claimed to inhibit angiogenesis and tumor cell proliferation were also found in C. cebuense. However, there have been no reported studies that verified its antiangiogenic activity. In the present study, the C. cebuense' santiangiogenic property was investigated via CAM assay with five different treatments of C. cebuense's leaf aqueous extract (CCE) following a completely randomized design: 100% (T1), 50% (T2), 25% (T3), 12.5% (T4), and 6.25% (T5). Sixteen-day old duck eggs were harvested after 15 days incubation, embryos assessed morphologically, angiogenesis quantified by photo documentation of the CAMs, and fractal dimension index analyzed using Image J analysis software. Results revealed that crown to rump length (CRL), hindlimb, forelimb, and beak lengths for other treatments were not dose-dependent except for T1 (100%) where embryos were clearly stunted in all its morphological development. The lowest mean fractal index (MFI=0.3042) among the experimental groups was also evident in T1 (100%). The results show strong evidence that T1 (100%) is the most potent concentration for CCE that could inhibit angiogenesis, and thus possibly restrain proliferation and metastasis of cancer cells.

show abstract

Cinnamomum cebuense Kosterm Lauraceae

Dapar

2021

Ethnobotany of Mountain Regions

View full text Add to dashboard Cite

Cytotoxic and Antimicrobial Compounds from Cinnamomum cebuense Kosterm. (Lauraceae)

Cited by 5 publications

References 6 publications

Cinnamomum cebuense Kosterm Lauraceae

Cinnamomum cebuense Kosterm Lauraceae

Antiangiogenic and morphological effects of Cinnamomum cebuense Kosterm. leaf extracts on Anas platyrynchos L. embryonic development usingan in vivo chorioallantoic membrane (CAM) assay

Cinnamomum cebuense Kosterm Lauraceae

Contact Info

Product

Resources

About