Cytotoxic and anti-oxidative constituents from Garcinia subelliptica

Zhang, L. J.; Kuo, Li Ming Yang; Liao, CC; Kuo, Yao‐Haur

doi:10.1055/s-0028-1084417

Cited by 1 publication

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“…Isolated from the fruits of G. subelliptica, garcinielliptone FB displayed marginal cytotoxicity against MCF-7, Hep 3B, and HT-29 human cancer cell lines [ 33 ]. An initial study on benzophenonoids isolated from the fruit of G. subelliptica reported that xanthochymol was moderately cytotoxic to MCF-7, Hep2, HeLa, and KB human cancer cells [ 24 ]. A follow-up study by the same group of scientists [ 25 ] reported that all benzophenonoids from the fruit of G. subelliptica displayed cytotoxicity against A549, DU145, KB, and vincristine-resistant KB human tumor cell lines with inhibitory concentration 50% (IC 50 ) values ranging from 3.3 to 7.3 µg/ml.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Garcinia subelliptica (Fukugi): A Multi-purpose Coastal Tree with Promising Medicinal Properties

Inoue

Kainuma²,

Baba³

et al. 2017

J Intercult Ethnopharmacol

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In this short review, the current knowledge on the botany, ecology, uses, and medicinal properties of the multipurpose Garcinia subelliptica (Fukugi) is updated. As yet, there are no reviews on this indigenous and heritage coastal tree species of the Ryukyu Islands in Japan, which has ethnocultural, ecological, and pharmacological significance. Planted by the Okinawan people some 300 years ago, Fukugi trees serve as windbreaks and accord protection against the destructive typhoons. The species has become a popular ornamental tree, and its bark has been used for dyeing fabrics. It forms part of the food chain for mammals and insects and serves as nesting sites for birds. Endowed with bioactive compounds of benzophenones, xanthones, biflavonoids, and triterpenoids, G. subelliptica possesses anticancer, anti-inflammatory, anti-tyrosinase, trypanocidal, antibacterial, DNA topoisomerase inhibitory, DNA strand scission, choline acetyltransferase enhancing, hypoxia-inducible factor-1 inhibitory, and antiandrogenic activities. Fukugetin and fukugiside are two novel biflavonoids named after the species. The chemical constituents of Fukugi fruits when compared with those of mangosteen yielded interesting contrasts.

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Section: Pharmacological Activitiesmentioning

confidence: 99%