Cytotoxic and anti-angiogenic effects of zoledronic acid in DU-145 and PC-3 prostate cancer cell lines

Antiproliferative, proapoptotic, and tumor‐suppressing effects of the novel anticancer agent alsevirone in prostate cancer cells and xenografts

“…CYP17A1 inhibitors are known to exert pronounced apoptotic effects through activation of caspase-3 in PC-3 cells and DNA fragmentation. [23] Caspase 3/7 activity was measured to verify apoptosis and alsevirone induced an increase in caspase 3/7 activity similar to zoledronic acid in DU-145 cells as described in reference [24].…”

High affinity zoledronate-based metal complex nanocrystals to potentially treat osteolytic metastases

“…21 However, recent studies have demonstrated that ZOLE exhibits direct cytotoxicity effects against human cancer cell models, recommending its use as a chemotherapeutic agent. [22][23][24][25] Several attempts have been made by employing ZOLE to design effective therapies against bone-related diseases, such as coordination complexes for drug delivery, 21,26,27 and radiopharmaceuticals as a bone pain therapy for oncological diseases. 15,[28][29][30] However, these approaches focused mainly on the labeling efficiency of ZOLE to beta emitters, adsorption to hydroxyapatite (HA), biodistribution, and cytotoxicity of the proposed systems through in vitro assays employing prostate, lung, and liver cancerous cells.…”