The phase-inversion hydrothermal synthesis of alendronate and Ca(ii) promotes the formation of a coordination complex whose solid-state, stability, particle size and cytotoxicity were assessed and optimized to potentiate its biomedical applications.
Formation of several materials denominated as bisphosphonate-based coordination complexes (BPCCs), resulted from the reaction between clinically employed bisphosphonate, zoledronate (ZOLE) and bioactive metals (M2+ = Ca2+, Mg2+ and Zn2+) salts....
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