Cytotoxic Activity of Some Anatolian<i>Salvia</i>. Extracts and Isolated Abietane Diterpenoids

Topcu, Gülaçtı; Türkmen, Zeynep; Schilling, Jennifer K.; Kingston, David G. I.; Pezzuto, J. M.; Ulubelen, Ayhan

doi:10.1080/13880200701735411

Cited by 33 publications

(17 citation statements)

References 26 publications

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“…Considering the growth inhibitory effect of the different ingredients isolated from Salvia species on tumor cell lines, the plant has become popular for anticancer evaluations. 5,16-Dihydrotanshinone I (Chuang et al, 2011), tanshinone IIA (Sung et al, 1999;Liu et al, 2012) compounds of Salvia miltiorrhiza, rosmarinic acid from Salvia fruticosa and Salvia officinalis (Xavier et al, 2009), royleanone, horminone, and acetyl horminone from the roots of S. officinalis (Slamenová et al, 2004); 6a-hydroxysalvinolone, 6a-hydroxytaxodone, aethiopinone, microstegiol, ferruginol, saprorthoquinone, 11,12-dioxoabieta-8,13-diene, taxodione, hypargenin A, hypargenin D isolated from Salvia hypargeia (Ulubelen et al, 1999;Topçu and Gören, 2007;Topcu, 2008) were effective in inhibiting proliferation and had cytotoxic activity against a panel of cell lines including human breast cancer, human lung cancer, human colon cancer, human prostate cancer and mouse lymphocytic leukemia.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and apoptogenic properties of three isolated diterpenoids from Salvia chorassanica through bioassay-guided fractionation

Tayarani‐Najaran

Mousavi

Tajfard

et al. 2013

Food and Chemical Toxicology

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Section: Discussionmentioning

confidence: 99%

Cytotoxic and apoptogenic properties of three isolated diterpenoids from Salvia chorassanica through bioassay-guided fractionation

Tayarani‐Najaran

Mousavi

Tajfard

et al. 2013

Food and Chemical Toxicology

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“…Peaks 10, (12, 20), 22, 29 and 30 were tentatively identified as paramiltioic acid, salvicanaric acid, royleanone, salviviridinol, α-linolenic acid and α-linoleic acid, respectively. These compounds had been isolated from different Salvia species than S. officinalis (Sun, Luo, Sakai, & Niwa, 1991;Topcu et al, 2008;de Saizieu et al, 2008;Ulubelen et al, 2000;Kilic, Dirmenci, & Goren, 2007;Chicco, D'Alessandro, Hein, Oliva, & Lombardo, 2009).…”

Section: Hplc-dad-esi-tof-ms Analyses Of the Antioxidant Fractionsmentioning

confidence: 97%

Supercritical carbon dioxide extraction of antioxidant fractions from selected Lamiaceae herbs and their antioxidant capacity

Babović

Djilas

Jadranin

et al. 2010

Innovative Food Science & Emerging Technologies

129

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“…Compound 56 and 53 had high cytotoxicity against A2780 cells (human ovarian cancer; IC 50 : 3.9 and 1.2 lg/ml, respectively) (Topçu et al 2008).…”

Section: Biological Activitymentioning

confidence: 99%

Bioactive phytochemicals from shoots and roots of Salvia species

et al. 2015

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The plants of the genus Salvia L. are important medicinal herbs of the Lamiaceae family and some of them such as S. officinalis (sage), S. miltiorrhiza (red sage, Danshen) and S. sclarea (clary sage) have been used as medicinal plants in the folk medicine of several countries. In this review, we discuss the reports that have examined Salvia species with the aim of isolation of pure compounds with different biological activities. The phytochemical analyses of various sage plants have reported 10 monoterpenoids (1-10), 1 sesquiterpenoid (11), 8 labdane (13-20), 15 ent-kaurane (21-35), 82 abietane, rearranged abietane and tanshinone (36-117), 3 icetexane (118-120), 43 clerodane (121-163), and 3 pimarane (164-166) diterpenoids with cytotoxic and antimicrobial, antiprotozoal, antioxidant, phytotoxic and insecticide effects. The other heavier terpenoids, including 3 sesterterpenes (167-169), 10 triterpenoids and b-sitosterol (170-180) have been introduced as minor bioactive compounds in the sage plants. Sahandinone (107), 6,7-dehydroroyleanone, 7-a-acetoxyroyleanone (40), and tanshinone like diterpenoids have been isolated from the roots' extracts of different Salvia species. On the other hand, several radical scavenger phenolic compounds like simple phenolics and caffeic acid derivatives (181-201) including rosmarinic acid, flavonoids (202-217) as well as phenolic diterpenoids, such as carnosol and carnosic acid have been isolated from the aerial parts of these plants. One pyrrole (218) and 3 antimicrobial oxylipins (219-221) are among the other less detected constituents in the members of Salvias. Furthermore, sages also synthesize antifungal, antileishmanial and antimalarial phytochemicals in their roots and shoots, which are reviewed in this paper. We also examine the allelopathic phenomena and the ecologically important phytochemicals identified in different parts of the sage plants. Finally, antifeedant and insecticide phenomena, which are due to the presence of volatile monoterpenes and clerodane diterpenes in these plants, are discussed. Considering the presence of diverse biologically active phytochemicals in the sage plants, they can be suggested as suitable candidates for the formulation of valuable natural medicines.

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Cytotoxic Activity of Some AnatolianSalvia. Extracts and Isolated Abietane Diterpenoids

Cited by 33 publications

References 26 publications

Cytotoxic and apoptogenic properties of three isolated diterpenoids from Salvia chorassanica through bioassay-guided fractionation

Cytotoxic and apoptogenic properties of three isolated diterpenoids from Salvia chorassanica through bioassay-guided fractionation

Supercritical carbon dioxide extraction of antioxidant fractions from selected Lamiaceae herbs and their antioxidant capacity

Bioactive phytochemicals from shoots and roots of Salvia species

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