Cytotoxic and apoptogenic properties of three isolated diterpenoids from Salvia chorassanica through bioassay-guided fractionation

Tayarani‐Najaran, Zahra; Mousavi, Seyed Hadi; Tajfard, Faezeh; Asili, Javad; Soltani, Saeid; Hatamipour, Mahdi; Emami, Seyed Ahmad

doi:10.1016/j.fct.2013.03.037

Cited by 42 publications

(27 citation statements)

References 30 publications

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“…The extraction method was done according to previously reported protocol (Tayarani-Najaran et al, 2013) (Figure 1). The essential oil (EO) was prepared, using a Cleavenger type apparatus after 3 h hydrodistillation of the aerial parts (100 g) of N. cataria.…”

Section: Plant Materialsmentioning

confidence: 99%

Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines

Emami

Asili

Nia³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Section: Plant Materialsmentioning

confidence: 99%

Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines

Emami

Asili

Nia³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…Terpenes and polyphenols content are thought to be responsible for the bioactivity of sage extracts (Marchev et al 2014). Multiple diterpenoids including taxodione have been extracted from the roots of S. chorassanica (Tayarani-Najaran et al 2013). Since 1969 there are several reports on biological activity of taxodione, which mainly focused on the cytotoxic activity of the compound (Tayarani-Najaran et al 2013;Kupchan et al 1968).…”

Section: Introductionmentioning

confidence: 99%

“…Multiple diterpenoids including taxodione have been extracted from the roots of S. chorassanica (Tayarani-Najaran et al 2013). Since 1969 there are several reports on biological activity of taxodione, which mainly focused on the cytotoxic activity of the compound (Tayarani-Najaran et al 2013;Kupchan et al 1968). DNAbinding ability (Zaghloul et al 2008) antimicrobial (Kuzma et al 2012, insecticidal (Fraga et al 2005), and neuronal GABAA receptor blockage effects (Rutherford et al 1994) are among the different biological activities related to taxodione.…”

Section: Introductionmentioning

confidence: 99%

Anti-apoptotic Effect of Taxodione on Serum/Glucose Deprivation-Induced PC12 Cells Death

et al. 2014

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Taxodione, a diterpenoid from the roots of Salvia chorassanica Bunge, possesses cytotoxic, apoptotic, and antimicrobial activity. This study was designed to investigate the protective effects of taxodione on serum/glucose deprivation-induced ischemic injury in PC12 cells and related mechanisms. In an in vitro model of ischemia, PC12 cells were exposed to serum and glucose deprivation for 6 and 18 h. The protective effects of the methanol extract of S. chorassanica and taxodione were assessed using alamarBlue(®) assay. Intracellular ROS production was measured by fluorimetry using 2',7'-dichlorofluorescin diacetate (DCFH-DA). The levels of PARP, Bcl-2, and Bax proteins were detected after western blot analysis. It was shown that taxodione (0.2-1.5 μM) significantly increased cell viability in a dose-dependent manner after ischemic insult. Taxodione has antioxidant activity and protects PC12 cells against oxidative stress-induced apoptotic cell death. Meanwhile, pretreatment with taxodione significantly induced an increase in Bcl-2 and a decrease in Bax protein level. The results of this study confirmed the protective effect of taxodione in serum/glucose deprivation-induced ischemic injury and the putative role of apoptosis as a underling mechanisms. Thus, it would be fair to consider taxodione as a promising ingredient of S. chorassanica for the expansion on novel class of anti-ischemic agents.

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“…Semi-preparative chromatography was used to fractionate selected berry extracts with potential bioactive properties using a hybrid approach of bioassay-guided fractionation procedure (Yang et al 2001;Weller 2012;Tayarani-Najaran et al 2013) and screening of pure compounds (Watts et al 2010). Bioassay-guided fractionation typically involves the following steps: assessment of bioactivity, extraction of the biological material with different solvents and testing of bioactivity.…”

Section: Berry Extract Bioactivity Screeningmentioning

confidence: 99%

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

et al. 2017

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BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production This article is written by the BacHBerry consortium (www. bachberry.eu) and represents the collective effort of all participating institutions. The authors are therefore listed in alphabetical order.Electronic supplementary material The online version of this article

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Cytotoxic and apoptogenic properties of three isolated diterpenoids from Salvia chorassanica through bioassay-guided fractionation

Cited by 42 publications

References 30 publications

Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines

Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines

Anti-apoptotic Effect of Taxodione on Serum/Glucose Deprivation-Induced PC12 Cells Death

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

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