Cytotoxic activity of polyacetylene compounds in Panax ginseng C.A. Meyer.

Matsunaga, Hisashi; Katano, Mitsuo; Yamamoto, Hiroshi; Fujito, Hiroshi; Mori, Masato; Takata, Katsumi

doi:10.1248/cpb.38.3480

Cited by 168 publications

(101 citation statements)

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“…Saponin and non-saponin ingredients of ginseng contain activity inhibiting a variety of cancer cell growth [17][18][19][20][21][22][23][24][25][26][27] .…”

Section: Efficacy Of Preventing Cancer and Activate Antitumor Immunitymentioning

confidence: 99%

Botanical characteristics, pharmacological effects and medicinal components of KoreanPanax ginsengC A Meyer

Choi

2008

Acta Pharmacologica Sinica

540

383

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Korean Panax ginseng C A Meyer is mainly used to maintain the homeostasis of the body, and the pharmacological efficacy of Korean ginseng identified by modern science includes improved brain function, pain-relieving effects, preventive effects against tumors as well as anti-tumor activity, enhanced immune system function, anti-diabetic effects, enhanced liver function, adjusted blood pressure, anti-fatigue and anti-stress effects, improved climacteric disorder and sexual functions, as well as anti-oxidative and anti-aging effects. Further clinical studies of these pharmacological efficacies will continue to be carried out. Korean ginseng is found to have such main properties as ginsenoside, ployacetylene, acid polysaccharide, anti-oxidative aromatic compound, and insulin-like acid peptides. The number of ginsenoside types contained in Korean ginseng (38 ginsenosides) is substantially more than that of ginsenoside types contained in American ginseng (19 ginsenosides). Furthermore, Korean ginseng has been identified to contain more main non-saponin compounds, phenol compounds, acid polysaccharides and polyethylene compounds than American ginseng and Sanchi ginseng.

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“…Saponin and non-saponin ingredients of ginseng contain activity inhibiting a variety of cancer cell growth [17][18][19][20][21][22][23][24][25][26][27] .…”

Section: Efficacy Of Preventing Cancer and Activate Antitumor Immunitymentioning

confidence: 99%

Botanical characteristics, pharmacological effects and medicinal components of KoreanPanax ginsengC A Meyer

Choi

2008

Acta Pharmacologica Sinica

540

383

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“…The polysaccharide revealed anticomplementary activity (64,65), reticuloendothelial system-potentiating activity, alkaline phosphatase-inducing activity (66), and cytoprotective activity (67,68). Lately, various polyacetylenes extracted from ginseng (69,70) are known to have cytotoxic activity (71).…”

Section: Identification Of Active Anticarcino-genic Components In Redmentioning

confidence: 99%

Anticarcinogenic Effect of Panax ginseng C.A. Meyer and Identification of Active Compounds

Yun¹,

Lee²,

Lee³

et al. 2001

J Korean Med Sci

206

138

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The failure to improve the five-year survival rate of cancer patients, from one in three in the 1960s to one in two in the 1970s, stimulated awareness of the importance of primary prevention of cancer. Korean investigators carried out extensive long-term anticarcinogenicity experiments with 2000 newborn mice to investigate whether Panax ginseng C.A. Meyer inhibited carcinogenesis induced by several chemical carcinogens in 1978. There was a 22% decrease (p <0.05) in the incidence of urethane induced lung adenoma by the combined use of red ginseng extract. In the group sacrificed at 56 weeks after the treatment with aflatoxin B1, the incidence of hepatoma significantly decreased to 75% by the addition of red ginseng extract (p <0.05). The result showed that natural products can provide hope for human cancer prevention. By the newly established '9 week mediumterm anticarcinogenicity test model of lung tumors in mice' (Yun' s model), we confirmed significant anticarcinogenic effects of powders and extracts of the 6-yr-old dried fresh ginseng, 5-and 6-yr old white ginsengs, and 4-, 5-, and 6-yr old red ginseng. We also demonstrated that the anticarcinogencity of ginseng was more prominent in aged or heat treated extracts of ginseng and red ginseng made by steaming. To investigate the active components for cancer prevention, several fractions of 6-yr old fresh ginseng and red ginseng, four semi-synthetic ginsenoside Rh1, Rh2, Rg3 and Rg5, major saponin components in red ginseng, were prepared. Among the ginsenosides, Rg3 and Rg5 showed statistically significant reduction of lung tumor incidence and Rh2 had a tendency of decreasing the incidence. Ginsenoside Rg3, Rg5 and Rh2 were found to be active anticarcinogenic compounds. Rg3, Rg5 and Rh2 are active components in red ginseng, and they prevent cancer either singularly or synergistically.

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“…Different parts of this plant are used by over 38 linguistic groups for over 34 categories of physical ailment, as well as for many spiritual applications (Lantz et al, 2004). From this plant, substances such as falcarindiol (9-heptadecadiene-4,6-diyne-3,8-diol) (CAS 55297-87-5), oploxyne A (9,10-epoxyheptadeca-4,6-diyne-3,8-diol), and oploxyne B (10- Falcarinol (1,9-heptadecadiene-4,6-diyn-3-ol) (CAS 21852-80-2), was firstly isolated from Falcaria vulgaris (Bohlmann et al, 1966), later from Korean ginseng (Matsunaga et al, 1990) and also from carrot (Zidorn et al, 2005). Falcarinol has potent anticancer properties on primary mammary epithelial cells (Christensen et al, 2011).…”

Section: Alcohols With Triple Bondsmentioning

confidence: 99%

Toxic Alcohols: Aliphatic Unsaturated Alcohols

Patočka¹,

Nepovímová²,

Kuča³

2016

Mil. Med. Sci. Lett.

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SummaryShort-chain unsaturated aliphatic alcohols exist as volatile liquids, some of them are used in both industrial and non-industrial environments, and some of them are natural products of different organisms. These alcohols very often work as semiochemicals, including acting as pheromones, attractants, repellents, etc.. Long-chain poly-unsaturated alcohols are often toxic principals of certain plants, thereby presenting a risk to humans.

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Cytotoxic activity of polyacetylene compounds in Panax ginseng C.A. Meyer.

Cited by 168 publications

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Botanical characteristics, pharmacological effects and medicinal components of KoreanPanax ginsengC A Meyer

Botanical characteristics, pharmacological effects and medicinal components of KoreanPanax ginsengC A Meyer

Anticarcinogenic Effect of Panax ginseng C.A. Meyer and Identification of Active Compounds

Toxic Alcohols: Aliphatic Unsaturated Alcohols

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