Cytostatic Activity of Sesquiterpene Lactones from Compositae of the Canary Islands

Abstract

isolated from members of the Compositae of the Canary Islands. Nine of these The c~tostatic properties of a series of compounds were isolated for the first fifteen lactones from some Compositae in the Institute de Productos Nacollected in the Canary Islands were turales Orginicos, Tenerifem examined. Nine of these lactones were isolated for the first time in the Instituto de Productos Naturales Orginicos of Material and Methods Tenerife. It would seem that an a-methylene-y-lactone grouping in the mole-The products under study are all sesquitcrpene lactones. Figure 1 shows their chemical is for c~totOxic structure and are listed with the plant species from which they were prepared:

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

“…Centaurea webbiana Gonzalez et al (1972bGonzalez et al ( , 1977aGonzalez et al ( , 1978a Gonzalez et al (1970Gonzalez et al ( , 1977aGonzalez et al ( , 1978a, Rybalko et al (1975), Khan et al (2010) against six bacteria and eight fungal species. All compounds showed greater antibacterial and antifungal activities than the positive control used, streptomicyn and miconazole, respectively (Djeddi et al, 2007(Djeddi et al, , 2008b.…”

“…Öksük and Topçu (1994) Chartolepis pterocaula Nowak et al (1986cNowak et al ( , 1996, Nowak (1990Nowak ( , 1992 239 Nowak et al (1986dNowak et al ( , 1996, Nowak (1990Nowak ( , 1992Nowak ( , 1993a Nowak et al (1986dNowak et al ( , 1996, Nowak (1990Nowak ( , 1992Nowak ( , 1993a Nowak et al (1986dNowak et al ( , 1996, Nowak (1990Nowak ( , 1992Nowak ( , 1993a Rybalko et al (1975), Nowak et al (1986aNowak et al ( ,c, 1996, Adekenov et al (1986bAdekenov et al ( , 1991, Nowak (1992), Adekenov (1995) Chartolepis pterocaula Nowak et al (1986cNowak et al ( , 1996, Nowak (1990Nowak ( , 1992) Grossheimia macrocephala Rybalko et al (1964), Rybalko et al, 1975, Rybalko andSheichenko (1965), Rybalko (1970, 1972), Bialecki et al (1973), Gonzalez et al (1977aGonzalez et al ( , 1978a, Daniewski et al (1982), Barbetti et al (1985), Nowak et al (1986a), Monea (1986), Piacentini et al (1986…”

“…drakiensis Nowak et al (1984), Gousiadou and Skaltsa (2003) Centaurea attica ssp. ossaea Nowak et al (1984), Gousiadou and Skaltsa (2003) Centaurea bombycina Barrero et al (2000) Centaurea bruguierana Rustaiyan et al (1982), Harraz et al (1994) Centaurea calcitrapa Drozdz (1967), Rybalko et al (1975), Gonzalez et al (1977a), Gonzalez et al, 1978a, Karawya et al (1975, Geppert et al (1983), Jakupovic et al (1986), Marco et al (1992) …”

“…In this study, information about two species of this section and their sesquiterpenoid profile, characterized by the presence of guaianes only, is included. Gonzalez et al (1971Gonzalez et al ( , 1975Gonzalez et al ( , 1977aGonzalez et al ( , 1978a, Rybalko et al (1975) -hydroxy-15-oxo-5,7aH,6,11bH-elema-1,3-dien-12,6-olide Centaurea paui Cardona et al (1997), Gousiadou and Skaltsa (2003) 86…”

“…Dihydroestafiatone (270), on the other hand, showed poor cytostatic action (Gonzalez et al, 1978a). Compounds 224,217,212,228,227,162, and 149 were also tested for cytostatic action on HeLa cells: the first four exhibited an ID 50 in the range 0.25-0.5 lg/mL (Gonzalez et al, 1980b).…”