Cytosolic drug delivery using pH- and light-sensitive liposomes

Gerasimov, Oleg V.; Boomer, Jeremy A.; Qualls, Marquita M.; Thompson, David H.

doi:10.1016/s0169-409x(99)00035-6

Cited by 222 publications

(162 citation statements)

References 135 publications

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“…These groups constitute an attractive trigger because UV light induced Wolff rearrangement of DNQ to a 3-indenecarboxylic acid group with hydrophilic properties enhancing water solubility of that compound. Moreover, infrared light can be applied in photodynamic therapy [217][218][219][220] and liposome degradation [221]. Furthermore, mechanopores along the polymer poly(methyl acrylate) backbone (e.g., cyclobutane mechanopores) can be activated in polymers containing a coumarin dimer probe by mechanochemical scisson under pulsed ultrasound conditions (sonochemical) in solid state [222].…”

Section: Non-fluorescent Prodrugs/converted Into Fluorescent Active Dmentioning

confidence: 99%

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Miksa¹

2016

Med chem (Los Angeles)

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This review highlights the role of fluorescent dyes as active "molecular photoswiches" focusing on the application in bioimaging and anticancer therapies in the field of therapeutic delivery. The author describes the development of prodrugs targeted to specific cell types and polymeric nanocarriers (capsules, micelles and silica nanoparticles) used as fluorescent probes which offer advantages in the integration of "smart" features of fluorescent dyes into synthetic materials. The incorporation of biologically responsive components that cleave upon changes in pH or light irradiation is fundamental to the successful design of such carriers with capabilities to load and release therapeutics specifically at a target site.

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Section: Non-fluorescent Prodrugs/converted Into Fluorescent Active Dmentioning

confidence: 99%

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Miksa¹

2016

Med chem (Los Angeles)

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“…The early work involving SO-mediated release was reported by Thompson et al [39][40][41][42]. They demonstrated that SO could release compounds from liposomes via photooxidation of the plasmalogen vinyl ether linker.…”

Section: Laser On Laser Offmentioning

confidence: 99%

Emerging Strategies for Controlling Drug Release by Using Visible/Near IR Light

Bio¹,

You²

2013

Med Chem

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Effective drug delivery systems require controlled drug release at the target cancer cell. While strategies for targeting tumors have been extensively studied, a better understanding of the necessary technology for controlling the spatiotemporal release of a drug is still needed. It has been established that the use of light can be a unique tool for controlling drug release. While UV light can be used for the release of biologically active, caged (deactivated) compounds, clinical application is restricted because of its limited ability to penetrate tissues as well as its cytotoxicity. Recently, the use of both tissue-penetrable visible and near IR have shown promise to overcome these limitations. In this short review, we introduce new smart strategies to convert such low energy light to a tissue-penetrable stimulus for both actively and remotely controlling drug release.

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“…Such plasma stable liposomes are known as pH-sensitive liposomes (Hong et al, 2002). The concept of pH-sensitive liposomes tremendously improves the intracellular delivery of various materials such as anti-tumor drugs, toxins, proteins and DNA (Gerasimov et al, 1999;Roux et al, 2004). The pH-sensitive liposomes offer the protective effects of other liposomal formulations with specific environment-controlled drug release.…”

Section: Introductionmentioning

confidence: 99%

A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery

2014

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The pH-sensitive liposomes have been extensively used as an alternative to conventional liposomes in effective intracellular delivery of therapeutics/antigen/DNA/diagnostics to various compartments of the target cell. Such liposomes are destabilized under acidic conditions of the endocytotic pathway as they usually contain pH-sensitive lipid components. Therefore, the encapsulated content is delivered into the intracellular bio-environment through destabilization or its fusion with the endosomal membrane. The therapeutic efficacy of pHsensitive liposomes enables them as biomaterial with commercial utility especially in cancer treatment. In addition, targeting ligands including antibodies can be anchored on the surface of pH-sensitive liposomes to target specific cell surface receptors/antigen present on tumor cells. These vesicles have also been widely explored for antigen delivery and serve as immunological adjuvant to enhance the immune response to antigens. The present review deals with recent research updates on application of pH-sensitive liposomes in chemotherapy/ diagnostics/antigen/gene delivery etc.

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Cytosolic drug delivery using pH- and light-sensitive liposomes

Cited by 222 publications

References 135 publications

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Emerging Strategies for Controlling Drug Release by Using Visible/Near IR Light

A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery

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