Cytoprotective and antioxidant effects of ethanolic extract of red dragon fruit (Hylocereus polyrhizus) and carrot (Daucus carota L.)

Abstract

Abstract. Red dragon fruit (Hylocereus polyrhizus) and carrot (Daucus carota L.) have been known for their phenolic and flavonoid compounds with antioxidants properties. Antioxidant activities including β-carotene bleaching (BCB) and Cupric ion Reducing Antioxidant Capacity (CUPRAC) and total phenolic content (TPC), total flavonoid content (TFC), and cytoprotective effect of the red dragon fruit and carrot extracts have been investigated in this study. Various concentrations of red dragon fruit (25-150 μg/mL) and carrot (25-200 μg/mL) extracts were applied on fibroblast primary cell which has been previously treated with 1000 μM hydrogen peroxide (H2O2) on the cytoprotective test. Results demontrated that carrot extract had higher antioxidant activity, TPC, and TFC than red dragon fruit extract. It was found that red dragon fruit extract at concentration of 150 μg/mL and carrot extract at concentration of 200 μg/mL were not able to protect cells from H2O2 exposure.

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“…Daun sidaguri diketahui mengandung senyawa fenolik, flavonoid, glikosida, alkaloid, dan tanin (Dhalwal et al, 2007). Kandungan senyawa fenolik dan flavonoid dalam ekstrak tumbuhan telah diketahui bertanggungjawab pada aktivitasnya sebagai antioksidan (Hanifa et al, 2016). Ekstrak etanol daun sidaguri menunjukkan aktivitas antioksidan pada berbagai uji dengan pembanding asam askorbat, BHA, dan tokoferol asetat (Dhalwal et al, 2007;Narendhirakannan dan Limmy, 2010).…”

Phytochemical Screening and Antioxidant Activity in Dragon Fruit Plant Extracts as Immunomodulators in Pregnant Women

“…According to one study, red dragon fruit extract has a total flavonoid concentration of 0.75 mg EQ/100 g fw. 16 According to a another study, the red dragon fruit powder's total flavonoid content was 210.02 mg/100 g. 17 Red dragon fruit's antioxidant activity is significantly associated with its flavonoid level. 18 Red dragon fruit contains various types of flavonoids, including quercetin, kaempferol, and myricetin.…”

A Fluorescence Study on the Extracts of Red Dragon Fruit Peel in Various Solvents

“…Besides that, special attention has been made to the red dragon fruit, because it contains several bioactive natural products, e.g. flavonoid, carotenoid, and polyphenol, and has been thoroughly evaluated for its antiinflammatory, antioxidant, antibacterial, antidiabetic, and anticancer activities [10][11][12][13].…”