Cytoprotection by PGE2, pirenzepine or vagotomy: A transmission and scanning electron microscopic study in rats

Determination of tiropramide in human plasma by liquid chromatography–tandem mass spectrometry

“…1), has been used as antispasmodic drug in the treatment of irritable colon and biliary dyskinesia [1,2]. Tiropramide was extensively metabolized to N-desethyltiropramide, N-desethyl-N-despropyltiropramide, N-despropyltiropramide and hydroxytiropramide via N-desethylation, N-despropylation, and hydroxylation at N-propyl after oral administration of tiropramide to rats [3] and human [4,5].…”

Ultrastructural changes in chronic inflammatory enteropathies—a comparison between dogs and humans

“…Differential mucosal abnormalities in IBD (Table 2) included a preserved mucosal integrity with the loss of regular polygonal units and increased mucous production in patients with CD but sloughing and mucosal disintegration with decreased mucous production in UC patients (Trabucchi et al, 1986). Interestingly, these UC lesions could even be observed in endoscopically normal areas of the colon (Trabucchi et al, 1986;Bertini et al, 1998), making electron microscopy (EM) a sensitive tool to detect mucosal lesions and potentially deep remission.…”

“…Differential mucosal abnormalities in IBD (Table 2) included a preserved mucosal integrity with the loss of regular polygonal units and increased mucous production in patients with CD but sloughing and mucosal disintegration with decreased mucous production in UC patients (Trabucchi et al, 1986). Interestingly, these UC lesions could even be observed in endoscopically normal areas of the colon (Trabucchi et al, 1986;Bertini et al, 1998), making electron microscopy (EM) a sensitive tool to detect mucosal lesions and potentially deep remission. In other studies of human IBD, which focused on either CD or UC, the ultrastructural lesions evaluated included several alterations affecting the different structural units of the intestinal wall (Table 2) (Aluwihare, 1971;Ranlov et al, 1972;Myllarniemi and Nickels, 1980;Rickert and Carter, 1980;Lewis et al, 1984;Nyhlin and Stenling, 1984;Dvorak and Silen, 1985;Shields et al, 1985;Nagel et al, 1995;Bertini et al, 1998;Fratila and Craciun, 2010;Zhao et al, 2021;Zhou et al, 2023).…”

Late rejection of the mesh after laparoscopic hernia repair

“…Samples of the mesh taken from the right side, where it was surrounded by pus, and from the left, where it was still integrated with the host tissue, were processed for scanning and transmission electron microscopy [8]. Two different pictures were evident: on the right side, the mesh was full of red blood cells and granulocytes.…”