Cytoplasmic Ca2+ oscillations in human leukemia T-cells are reduced by 50 Hz magnetic fields

Galvanovskis, Juris; Sandblom, John; Bergqvist, Björn; Galt, Sheila; Hamnerius, Yngve

doi:10.1002/(sici)1521-186x(1999)20:5<269::aid-bem2>3.0.co;2-s

Cited by 35 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The drastic influence of magnetic field on Ca dynamics takes place at low frequencies that are comparable with the frequency of Ca concentration self-oscillations without a magnetic field. This result is in qualitative agreement with the experimental data [82] that the effects of magnetic influence on spectral power of the cytosolic Ca 2+ oscillator was observed at low frequencies (within the 0–10 mHz subinterval of the Ca 2+ oscillation spectrum) [82]. However, for the high frequency ranges (Fig.…”

Section: Resultssupporting

confidence: 92%

“…The significant impact on Ca dynamics from oscillating uniform and gradient magnetic fields (with the m -parameter ranging from 0.25 to 2.0) occurs at low frequencies comparable to the frequency of Ca concentration self-oscillations in the absence of a magnetic field. This finding qualitatively aligns with experimental data [86], where the impact of magnetic fields on the spectral power of the cytosolic Ca 2+ oscillations was observed at lower frequencies, specifically within the (0–10) mHz subinterval of the Ca 2+ oscillation spectrum. However, for the high frequency ranges (Fig.…”

Section: Resultssupporting

confidence: 91%

“…3), the change Ca concentrations caused by the MFs (Fig. 5 (A, B, C, D, E, F)) are not significant, which also in a good agreement with experiments [86].…”

Section: Superharmonic Resonance and Shift Of The Ca 2+ Spiking Frequ...supporting

confidence: 88%

See 2 more Smart Citations

Modulation of Calcium Signaling and Metabolic Pathways in Endothelial Cells with Magnetic Fields

Gorobets,

Polyakova

et al. 2023

Preprint

View full text Add to dashboard Cite

Calcium signaling plays a crucial role in various physiological processes, including muscle contraction, cell division, and neurotransmitter release. Dysregulation of calcium levels and signaling has been linked to a range of pathological conditions such as neurodegenerative disorders, cardiovascular disease, and cancer. Here, we suggest that in the endothelium, calcium ion channel activity and calcium signaling can be modulated by applying either a time-varying or static gradient magnetic field (MF). This modulation is achieved by exerting magnetic forces or torques on either biogenic or non-biogenic magnetic nanoparticles that are bound to endothelial cell membranes. Since calcium signaling in endothelial cells induces neuromodulation and influences blood flow control, treatment with a magnetic field shows promise for regulating neurovascular coupling and treating vascular dysfunctions associated with aging and neurodegenerative disorders. Furthermore, magnetic treatment can enable control over the decoding of Ca signals, ultimately impacting protein synthesis. The ability to modulate calcium wave frequencies using MFs and the MF-controlled decoding of Ca signaling present promising avenues for treating diseases characterized by calcium dysregulation.

show abstract

Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 91%

See 1 more Smart Citation

Modulation of Calcium Signaling and Metabolic Pathways in Endothelial Cells with Magnetic Fields

Gorobets,

Polyakova

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Electromagnetic fields have been hypothesized to affect the membrane permeability through modifications on channel-forming proteins [46]. Since we did not detect any differential expression of the OmpC and OmpF porins, we could hypothesize that the SMF may alter kinetics of beta-lactamase inhibition by clavulanic acid, thus reducing beta-lactamase activity.…”

Section: Discussionmentioning

confidence: 76%

Adaptation of Salmonella enterica Hadar under static magnetic field: effects on outer membrane protein pattern

et al. 2012

View full text Add to dashboard Cite

BackgroundSalmonella enterica serovar Hadar (S. Hadar) is a highly prevalent foodborne pathogen and therefore a major cause of human gastroenteritis worldwide. Outer membrane proteins whose production is often regulated by environmental conditions also play important roles in the adaptability of bacterial pathogens to various environments.ResultsThe present study investigated the adaptation of S. Hadar under the effect of acute static magnetic field exposure (200 mT, 9 h) and the impact on the outer membrane protein pattern. Via two-dimensional electrophoresis (2-DE) and LC-MS/MS spectrometry, we compared the proteome of enriched-outer membrane fraction before and after exposure to a magnetic field. A total of 11 proteins, displaying more than a two-fold change, were differentially expressed in exposed cells, among which 7 were up-regulated and 4 down-regulated. These proteins were involved in the integrity of cell envelope (TolB, Pal), in the response to oxidative stress (OmpW, dihydrolipoamide dehydrogenase, UspF), in the oxidative stress status (bacterioferritin), in virulence (OmpX, Yfgl) or in motility (FlgE and UspF). Complementary experiments associated the down-regulation of FlgE and UspF with an alteration of swarming, a flagella-driven motility, under SMF. Furthermore, the antibiotic disc diffusion method confirmed a decrease of gentamicin susceptibility in exposed cells. This decrease could be partly associated with the up-regulation of TolC, outer membrane component of an efflux pump. OmpA, a multifunctional protein, was up-regulated.ConclusionsSMF (200 mT) seems to maintain the cell envelope integrity and to submit the exposed cells to an oxidative stress. Some alterations suggest an increase of the ability of exposed cells to form biofilms.

show abstract

“…5(A-F)) are not signicant, which also in a good agreement with experiments. 91 In Fig. 3, the diagrams display characteristic traits associated with both the foldover effect and superharmonic resonance.…”

Section: Sensing Frequencies Of Decoding Proteinsmentioning

confidence: 99%

Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields

Gorobets,

Polyakova

et al. 2024

Nanoscale Adv.

View full text Add to dashboard Cite

show abstract

Cytoplasmic Ca2+ oscillations in human leukemia T-cells are reduced by 50 Hz magnetic fields

Cited by 35 publications

References 29 publications

Modulation of Calcium Signaling and Metabolic Pathways in Endothelial Cells with Magnetic Fields

Modulation of Calcium Signaling and Metabolic Pathways in Endothelial Cells with Magnetic Fields

Adaptation of Salmonella enterica Hadar under static magnetic field: effects on outer membrane protein pattern

Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields

Contact Info

Product

Resources

About