Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields

Gorobets, Oksana; Gorobets, Svitlana; Polyakova, Tatyana; Zablotskii, Vitalii

doi:10.1039/d3na01065a

Cited by 4 publications

(1 citation statement)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Not surprisingly, inflammation and LPS, at this granularity of modeling, indicate a relatively unif orm activation of all the f unctions identif ied. Conversely, mechanical force, which represents the indistinct mechanical stimulus that was modeled in our previous work 9 shows a visible enrichment on the tumor associated mTOR pathway 39 , this is in line with the literature that was adopted f or that reconstruction, which turned out to have a particular emphasis on EMT type III. This bias was among the motivations to update our network with the current work.…”

Section: Diffusion Analysissupporting

confidence: 83%

Mechanotransduction and inflammation: an updated comprehensive representation

Suryiagandhi,

Ma,

Paparozzi

et al. 2024

Preprint

View full text Add to dashboard Cite

Mechanotransduction is the process that enables the conversion of mechanical cues into biochemical signaling. While all our cells are well known to be sensitive to such stimuli, the details of the systemic interaction between mechanical input and inflammation are not always well integrated. Often, they are considered and studied in relatively compartmentalized areas, and we therefore argue here that to understand the relationship of mechanical stimuli with inflammation – with high translational potential - it is crucial to offer and analyze a unified view of mechanotransduction. We therefore offer here a pathway representation, recollected with the standard systems biology markup language (SBML) and explored with network biology approaches. We present RAC1 as an exemplar and emerging molecule with potential for medical translation.

show abstract

Section: Diffusion Analysissupporting

confidence: 83%

Mechanotransduction and inflammation: an updated comprehensive representation

Suryiagandhi,

Ma,

Paparozzi

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Modulatory Impact of Oxidative Stress on Action Potentials in Pathophysiological States: A Comprehensive Review

Mahapatra,

Thakkar,

Kumar

2024

Antioxidants

View full text Add to dashboard Cite

Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defenses, significantly affects cellular function and viability. It plays a pivotal role in modulating membrane potentials, particularly action potentials (APs), essential for properly functioning excitable cells such as neurons, smooth muscles, pancreatic beta cells, and myocytes. The interaction between oxidative stress and AP dynamics is crucial for understanding the pathophysiology of various conditions, including neurodegenerative diseases, cardiac arrhythmias, and ischemia-reperfusion injuries. This review explores how oxidative stress influences APs, focusing on alterations in ion channel biophysics, gap junction, calcium dynamics, mitochondria, and Interstitial Cells of Cajal functions. By integrating current research, we aim to elucidate how oxidative stress contributes to disease progression and discuss potential therapeutic interventions targeting this interaction.

show abstract

Cellular and Molecular Effects of Magnetic Fields

Tota,

Jonderko,

Witek

et al. 2024

IJMS

View full text Add to dashboard Cite

Recently, magnetic fields (MFs) have received major attention due to their potential therapeutic applications and biological effects. This review provides a comprehensive analysis of the cellular and molecular impacts of MFs, with a focus on both in vitro and in vivo studies. We investigate the mechanisms by which MFs influence cell behavior, including modifications in gene expression, protein synthesis, and cellular signaling pathways. The interaction of MFs with cellular components such as ion channels, membranes, and the cytoskeleton is analyzed, along with their effects on cellular processes like proliferation, differentiation, and apoptosis. Molecular insights are offered into how MFs modulate oxidative stress and inflammatory responses, which are pivotal in various pathological conditions. Furthermore, we explore the therapeutic potential of MFs in regenerative medicine, cancer treatment, and neurodegenerative diseases. By synthesizing current findings, this article aims to elucidate the complex bioeffects of MFs, thereby facilitating their optimized application in medical and biotechnological fields.

show abstract

Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields

Abstract: Calcium signaling plays a crucial role in various physiological processes, including muscle contraction, cell division, and neurotransmitter release. Dysregulation of calcium levels and signaling has been linked to a range...

Cited by 4 publications

References 113 publications

Mechanotransduction and inflammation: an updated comprehensive representation

Mechanotransduction and inflammation: an updated comprehensive representation

Modulatory Impact of Oxidative Stress on Action Potentials in Pathophysiological States: A Comprehensive Review

Cellular and Molecular Effects of Magnetic Fields

Contact Info

Product

Resources

About