Cytopathology and Ultrastructure of Primary Rhabdoid Tumor of Lung

Abstract

This case report presents the light microscopy, immunocytochemistry, and ultrastructure of the first unequivocal extrarenal rhabdoid tumor occurring in lung. Smears and cell blocks prepared from a fine-needle aspiration biopsy show the cytopathological features of this unusual neoplasm, in this case presenting in a 74-year-old male. Electron microscopy of the surgically resected circumscribed pulmonary mass assisted in establishing the diagnosis by demonstrating the considerable accumulation of cytoplasmic intermediate filaments that characterize cells in extrarenal rhabdoid tumor and account for the hyaline "inclusion" in this particular lesion.

Lung carcinoma with rhabdoid cells: a clinicopathological study and survival analysis of 14 cases

“…As it became evident that there was neither ultrastructural nor immunohistochemical evidence of rhabdomyoblastic differentiation, the term ‘rhabdoid cell’ was applied for the tumour cells having an eccentric nucleus and a hyaline paranuclear inclusion. Since then, tumours showing a rhabdoid morphology have been observed at a variety of sites including the lung 3–6 . Cavazza et al .…”

Malignant Rhabdoid Tumor with Cervical Vertebra Involvement in a Teenage Child: Case Report and Review of the Literature

“…From 2000 to 2002, 2 new congenital MRTs involving the right shoulder [8,9 ]and the soft tissues of the cheek have also been reported [10]. MRT has subsequently been recognized in various sites throughout the human body including the central nervous system, liver, soft tissues, skin, tongue and heart [11,12,13,14,15,16,17,18,19]. …”

Non–Small Cell Carcinomas of the Lung

“…[172][173][174][175][176][177][178][179][180][181][182] Malignant rhabdoid tumors appear to occur in a ubiquitous distribution, and those arising outside the kidney have been referred to as "extrarenal rhabdoid tumors" or "pseudorhabdoid tumors." The question of whether rhabdoid carcinoma of the lung is a specific clinicopathologic entity or a growth pattern is beyond the scope of this discusssion.…”

“…Rubenchik and associates 172 were the first to describe a "rhabdoid tumor" in the lung-an intrapulmonary tumor in a 74-year-old man. The tumor displayed rhabdoid features, and electron microscopy revealed the cytoplasmic intermediate filaments that characterize malignant rhabdoid tumors of the kidney.…”