Cytomorphologic features of metastatic endometrioid carcinoma by fine needle aspiration

Johnson, Daniel N.; Barroeta, Julieta E.; Antic, Tatjana; Lastra, Ricardo R.

doi:10.1002/dc.23855

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…The background of the aspirates is usually hemorrhagic and may show necrotic debris. The current case showed mixed endometrioid and adenosquamous patterns [16, 17]. In addition, there were also cohesive cellular clusters with areas of gland formation, nuclear overlapping, low to intermediate nuclear-to-cytoplasmic ratios, round to elongated nuclear shape, finely vacuolated cytoplasm, mild to moderate nuclear membrane irregularities, squamous metaplasia, and inconspicuous nucleoli [16].…”

Section: Discussion/conclusionmentioning

confidence: 96%

Axillary Nodal Metastasis with Papillary Morphology: An Uncommon Origin

Marabi¹,

Chan

et al. 2020

Acta Cytologica

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Background: Metastases to axillary lymph nodes are commonly and readily confirmed by fine needle aspiration cytology (FNAC). Most likely, these arise from breast primaries. However, the diagnosis can become complicated when unusual cytomorphology is encountered. Case: We report a 60-year-old woman presenting with bilateral axillary lymphadenopathies but without breast lesions. History showed increasing CA-125 levels. FNAC yielded carcinoma cells showing prominent papillary pattern, being composed of mild to moderately differentiated malignant cells, with focal abortive glandular formation and squamous metaplasia. IHC stains were done and the tumor cells were PAX-8 positive, but GATA-3 and GCDFP-15 negative. Coupled with the clinical history, a diagnosis of metastatic endometrioid adenocarcinoma was made. Conclusion: Nodal metastases with papillary cytomorphology can rarely arise from nonbreast primaries. The presence of papillary pattern, particularly in the absence of a clinically detectable breast lesion, should raise the possibility of a metastasis. Correlation with patient history, imaging findings and judicious use of IHC studies are crucial for a correct diagnosis.

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Section: Discussion/conclusionmentioning

confidence: 96%

Axillary Nodal Metastasis with Papillary Morphology: An Uncommon Origin

Marabi¹,

Chan

et al. 2020

Acta Cytologica

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“…Features of squamous metaplasia in the form of cells with dense cytoplasm and distinct cell borders may also be seen and can be very helpful in arriving at a diagnosis of endometrioid carcinoma on cytology. Occasional cases may reveal presence of intracytoplasmic mucin, indicative of mucinous differentiation in the tumor [45]. Of note, endometriosis can be difficult to distinguish from endometrioid carcinomas on cytology.…”

Section: Endometrioid Carcinomasmentioning

confidence: 99%

Role of Fine Needle Aspiration Cytology in the Diagnosis of Gynecologic Tumors

Goyal¹

2023

Acta Cytologica

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Background: The tumors involving the gynecologic tract encompass a wide range of lesions including those of epithelial, mesenchymal, sex cord-stromal, and germ cell origin. Amongst the carcinomas of tubo-ovarian origin, high-grade serous carcinoma is the most common malignancy. The primary role of fine needle aspiration (FNA) cytology in the management of gynecologic tract malignancies is in the diagnosis of their recurrences/metastases. In patients presenting with advanced disease, the cytology specimen may be the initial or the only sampling performed before the initiation of treatment. Summary: This review will discuss the cytologic findings of various gynecologic tract neoplasms with regard to their morphologic features, differential diagnoses, and the ancillary studies that can assist in their recognition. Key Messages: FNA cytology serves as a valuable tool in the diagnosis and management of gynecologic tract malignancies. However, making an accurate diagnosis of these entities, especially on limited cytology specimens, can be challenging. Awareness regarding the morphologic spectrum of these tumors, their potential mimics, and the ancillary studies that can be employed to refine their characterization, can assist in arriving at the correct diagnosis.

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