Cytomegalovirus seroprevalence in exposed and unexposed populations of hospital employees

Lepage, Nadège; Leroyer, Ariane; Chérot‐Kornobis, Nathalie; Lartigau, Isabelle; Miczek, Sophie; Sobaszek, Annie

doi:10.1007/s10096-010-1054-4

Cited by 10 publications

(11 citation statements)

References 26 publications

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“…Our findings reinforced prevalence results found in previous surveys conducted in France, targeted at specific sub-populations such as pregnant women or healthcare workers [22–24]. Furthermore, our prevalence estimates were comparable with those obtained in national surveys conducted in the general populations of other Western countries, such as the USA, the Netherlands and Australia [2, 27, 28].…”

Section: Discussionsupporting

confidence: 91%

Seroprevalence of cytomegalovirus infection in France in 2010

et al. 2017

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Cytomegalovirus (CMV) infection remains the leading cause of congenital virus infection in developed countries. Measuring the national prevalence of this infection, especially among women of childbearing age, is of great value to estimate the risk of congenital CMV infection, as well as to identify risk groups that should be targeted for behavioural interventions and/or vaccination once a CMV vaccine finally becomes available. In order to fulfil these objectives, a seroprevalence survey was conducted in 2010, using a nationally representative, population-based sample of 2536 people aged between 15 and 49 years, living in metropolitan France and attending private microbiological laboratories for blood testing. All blood samples were analysed in the same laboratory and screened for CMV-specific IgG using an enzyme-linked immunoassay technique (Elisa PKS Medac Enzyme immunoassay). The overall point estimate of CMV infection seroprevalence for individuals aged 15-49 years was 41.9%. The estimates were higher in women than in men (respectively 45.6% and 39.3%), and people born in a non-Western country were more likely to be CMV seropositive than those born in France or in another Western country (93.7% vs. 37.7%). Our results showed that a substantial percentage of women of childbearing age in France are CMV seronegative and therefore at risk of primary CMV infection during pregnancy. Educational measures and future vaccine are key issues to prevent infection in pregnant women and congenital CMV disease.

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Section: Discussionsupporting

confidence: 91%

Seroprevalence of cytomegalovirus infection in France in 2010

et al. 2017

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“…The only exception to this trend was observed in children less than 6 months who had high prevalence (84.4%) reflecting transient presence of transplacentally derived maternal IgG antibodies. Similar results were found in majority other studies [10,15,18,19,33]. Comparing seroprevalence in the similar age groups, some differences were found in children and adolescents.…”

Section: Discussionsupporting

confidence: 91%

“…Prevalence rates are reported to be 41%-92% in children and adolescents [12][13][14][15], 45%-94% in adult general population [14,[16][17][18][19], 30%-91.5% in pregnant women [20][21][22][23][24] and 68%-99% in hemodialysis patients [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology of cytomegalovirus infections in Croatia

Vilibić-Čavlek

Kolarić

Beader

et al. 2016

Wien Klin Wochenschr

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Objectives: Cytomegalovirus (CMV) is endemic worldwide, with marked differences in the seroprevalence rates between countries. The aim of this study was to analyze the seroprevalence of CMV infection in Croatia. Methods:During a three year period (2013)(2014)(2015), 2438 consecutive serum samples collected from Croatian residents were tested for the presence of CMV IgM and IgG antibodies using enzyme-linked immunoassay. IgM/IgG positive samples were further tested for IgG avidity. Results:The overall seroprevalence rates for CMV IgG and IgM antibodies were 74.4% and 4.3%, respectively. The IgG seroprevalence differed significantly between population groups: children/adolescents 54.6%, adult general population 77.2%, hemodialysis patients 91.4% (p<0.001). CMV seropositivity was strongly age-dependent with prevalence ranging from 53.0% in children less than 10 years to 93.8% in persons above 60 years (p<0.001). There was no difference in the prevalence between women with normal pregnancy and women with bad obstetric history. Gender and place of residence was not associated with CMV seropositivity.Using IgG avidity, current/recent primary CMV infection was confirmed by low/borderline avidity index (AI) in 46.7% participants, while in 53.3% high AI indicated CMV reactivation or reinfection. Primary infections were detected mainly in children and adolescents (83.2% and 70.5%), while reactivations/reinfections were common in persons older than 40 (77.0-100%). Reactivations/reinfections were most commonly detected in hemodialysis patients (92.3%). Logistic regression showed that older age and being on hemodialysis were significant predictors of CMV seropositivity.Conclusions: CMV is widespread in the Croatian population. Older age and being on hemodialysis appeared to be main risk factors for CMV infection.

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“…Some studies conducted in recent decades have suggested a low CMV risk for staff in children’s hospitals [ 27 ], [ 28 ], [ 29 ], [ 30 ], [ 31 ]. However, Lepage et al [ 32 ] described an increased CMV risk among paediatric care assistants as against employees with no contact with patients. (OR: 1.8; 95% CI 1.1–2.8).…”

Section: Discussionmentioning

confidence: 99%